High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China

Wang, Jing; Yang, Fan; Mao, Meng; Liu, Danhong; Yang, Huajun; Yang, Sufei

doi:10.1007/s12519-010-0224-x

Cited by 41 publications

(40 citation statements)

References 18 publications

(19 reference statements)

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“…The findings of the present study also confirm this relationship; serum levels of 25-hydroxyvitamin D in mothers and infants had a significant correlation within both exposed and non-exposed groups [5,33,34,36,37]. According to findings no significant difference was found in 25- hydroxy vitamin D, calcium, parathyroid hormone, and phosphorus and serum alkaline phosphatase levels of the umbilical cord between two groups.…”

Section: Discussionsupporting

confidence: 88%

“…Neonatal vitamin D status is highly related to the amount of transfused vitamin D through placenta and its levels at birth [34] and maternal vitamin D deficiency causes vitamin D deficiency in infants [35]. The findings of the present study also confirm this relationship; serum levels of 25-hydroxyvitamin D in mothers and infants had a significant correlation within both exposed and non-exposed groups [5,33,34,36,37].…”

Section: Discussionsupporting

confidence: 83%

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The effect of cigarette smoke exposure on vitamin D level and biochemical parameters of mothers and neonates

Banihosseini

Baheiraei

Shirzad

et al. 2013

J Diabetes Metab Disord

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BackgroundExposure to cigarette smoke during pregnancy leads to several adverse effects on mother and child. The purpose of this study was to evaluate the effect of being a passive smoker during pregnancy on vitamin D level and related biochemical indices including parathyroid hormone, calcium, phosphorus and alkaline phosphatase in mothers and newborns.MethodsOne hundred eight pregnant women and their newborns participated in a historical cohort study in two equal groups (n = 54) with and without cigarette smoke exposure. Maternal blood and urine samples and blood samples of umbilical cord were obtained in the delivery room. Concentration of 25-hydroxy vitamin D and related biochemical indices in samples of maternal and cord blood were investigated. Exposure to cigarette smoke was evaluated through questionnaire and maternal urine and umbilical cord serum cotinine levels.ResultsThe mean level of 25-hydroxyvitamin D in maternal serum was 9.28 ± 5.19 ng/mlin exposed and 10.75 ± 5.26 ng/ml in non-exposed group(p > 0.05). The mean concentration of 25-hydroxy vitamin D in cord serum was 10.83 ± 6.68 ng/ml in the exposed and 11.05 ± 4.99 ng/ml in the non-exposed group(p > 0.05). The exposed mothers had significantly higher parathyroid hormone level (p = 0.013), lower serum calcium (p = 0.024) and higher serum alkaline phosphatase (p = 0.024). There was a significant correlation between maternal and umbilical cord serum 25-hydroxyvitamin D within both exposed and non-exposed groups (p < 0.001).ConclusionMaternal exposure to cigarette smoking during pregnancy negatively influences serum calcium level and increase parathyroid hormone and alkaline phosphatase in mothers.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 83%

The effect of cigarette smoke exposure on vitamin D level and biochemical parameters of mothers and neonates

Banihosseini

Baheiraei

Shirzad

et al. 2013

J Diabetes Metab Disord

View full text Add to dashboard Cite

show abstract

“…No relationships were observed between ALP, Ca or inorganic P and any anthropometric measurements. (19) . The cut-off point used to define deficiency in that study was 25(OH)D , 37?5 nmol/l, and the mean concentration of 25(OH)D was 48?5 nmol/l in mothers and 41 nmol/l in cord blood (19) .…”

Section: General Characteristicsmentioning

confidence: 99%

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Song¹,

Si²,

Liu³

et al. 2012

Public Health Nutr.

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“…Sichuan Basin has special geographic characteristics, where the number of cloudy or rainy days is substantially larger than that in other regions in China, which may lead to a relatively lower level of vitamin D synthesis and calcium deficiency consequently [42]. However, to the best of our knowledge, no data were available currently on calcium supplementation during postpartum in other regions of China for comparison purpose.…”

Section: Discussionmentioning

confidence: 99%

Increased Calcium Supplementation Postpartum Is Associated with Breastfeeding among Chinese Mothers: Finding from Two Prospective Cohort Studies

Zhao

Binns

et al. 2016

Nutrients

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The calcium supplementation status during the postpartum period among Chinese lactating women is still unclear. The objective of this study is to utilize data from two population-based prospective cohort studies to examine the calcium supplementation status and to identify whether breastfeeding is associated with increased calcium supplementation among Chinese mothers after child birth. Information from 1540 mothers on breastfeeding and calcium supplementation measured at discharge, 1, 3, and 6 months postpartum were extracted to evaluate the association between breastfeeding and calcium supplementation postpartum. A generalized linear mixed model was applied to each study initially to account for the inherent correlation among repeated measurements, adjusting for socio-demographic, obstetric factors and calcium supplementation during pregnancy. In addition, breastfeeding status measured at different follow-up time points was treated as a time dependent variable in the longitudinal analysis. Furthermore, the effect sizes of the two cohort studies were pooled using fixed effect model. Based on the two cohort studies, the pooled likelihood of taking calcium supplementation postpartum among breastfeeding mothers was 4.02 times (95% confidence interval (2.30, 7.03)) higher than that of their non-breastfeeding counterparts. Dietary supplementation intervention programs targeting different subgroups should be promoted in Chinese women, given currently a wide shortage of dietary calcium intake and calcium supplementation postpartum.

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High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China

Abstract: There is a high prevalence of vitamin D and calcium insufficiency in pregnant women and neonates in Chengdu even when mothers are compliant with prenatal vitamin supplementation. Supplementation is needed to improve maternal and neonatal vitamin D and calcium nutrition.

Cited by 41 publications

References 18 publications

The effect of cigarette smoke exposure on vitamin D level and biochemical parameters of mothers and neonates

The effect of cigarette smoke exposure on vitamin D level and biochemical parameters of mothers and neonates

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Increased Calcium Supplementation Postpartum Is Associated with Breastfeeding among Chinese Mothers: Finding from Two Prospective Cohort Studies

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