Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Song, Shujun; Si, Shihui; Liu, Junli; Chen, Xingming; Zhou, Ling; Jia, Guiyue; Liu, Genlan; Niu, Yujing; Wu, Jie; Zhang, Wenying; Zhang, Jianzhong

doi:10.1017/s1368980012003084

Cited by 77 publications

(113 citation statements)

References 32 publications

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“…An inverse correlation of cord blood 25(OH)D levels at delivery and birth weight has been reported (8), whereas other studies have shown that newborns of mothers with severe vitamin D deficiency had shorter birth length, and smaller head circumference and birth weight (33). In the current meta-analysis, including 4 RCTs, vitamin D supplementation did not prevent the risk of low birth weight (<2,500 g).…”

Section: Vitamin D Supplementation and Low Fetal Birth Weight Small contrasting

confidence: 52%

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Pérez‐López

Pasupuleti

Mezones‐Holguín

et al. 2015

Fertility and Sterility

265

205

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Section: Vitamin D Supplementation and Low Fetal Birth Weight Small contrasting

confidence: 52%

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Pérez‐López

Pasupuleti

Mezones‐Holguín

et al. 2015

Fertility and Sterility

265

205

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“…A survey, conducted in Beijing (~40°N) and Shanghai (~31°N) from April to June in 2005, revealed that 69 % of the middle-aged and elderly people were vitamin D 'deficient' (25(OH)D < 50 nmol/l) and 24 % were vitamin D 'insufficient' (50 nmol/l ≤ 25(OH)D < 75 nmol/l) (53) . Furthermore, blood samples collected during April and May from healthy pregnant women and their newborn infants in a Beijing hospital indicated that none of the subjects had serum 25(OH)D concentration >75 nmol/l and half of them were in 'severe vitamin D deficiency' (25(OH)D < 25 nmol/l) (54) .…”

Section: Discussionmentioning

confidence: 99%

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Zhou

Zhu²,

Chen³

et al. 2014

Public Health Nutr.

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Objective: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city. Design: An intervention trial. Setting: Shenzhen City, Guangdong Province, China. Subjects: From a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18-69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.Results: For the survey, there was no significant difference (P > 0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P = 0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P < 0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men. Conclusions: For obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance. KeywordsVitamin D Obesity Chinese male Parathyroid hormone Insulin resistanceIn China, approximately 12 % of adult males are considered to be obese (1,2) . Since vitamin D nutritional status may be important in regulating obesity (3)(4)(5)(6) , interest was aroused to study Chinese obese males in this regard. Circulating 25-hydroxyvitamin D (25(OH)D; calcidiol), a metabolite of vitamin D having a half-life of 2-3 weeks, is recommended as a reliable marker of vitamin D nutritional status (7)(8)(9)(10) . The US Institute of Medicine (11) reports that a circulating 25(OH)D concentration equal to 50 nmol/l (20 ng/ml) meets the vitamin D requirements of 97·5 % of the population, and this threshold is widely accepted for hypovitaminosis D (10,(12)(13)(14) . Not satisfied with that basic requirement, many researchers claim that improvement of circulating 25(OH)D concentrations to much higher than 50 nmol/l can prevent a broad range of diseases (4,(15)(16)(17) .In addition, 25(OH)D ≤25 nmol/l (10 ng/ml) is considered to be 'severe vitamin D deficiency', 75-250 nmol/l (30-100 ng/ml) a 'sufficient or optimal' level and 50-75 nmol/l (21-29 ng/ml) an 'insufficient' level (12,13,18) , although these reference ranges are not defined by the Inst...

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“…A similar study involving newborns, which was held in China (Beijing -39.60 N) showed severe deficiency in 46.6% of the cases while no baby was detected with a proper level of vitamin D [20].…”

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confidence: 74%

Vitamin D levels in newborns children of Stavropol Region

Yakovlevich¹,

Viktorovna²,

Alexandrovna³

et al. 2015

Medical news of the North Caucasus

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Vitamin D has a wide range of biological effects. There is evidence suggesting an important role of vitamin D in women's reproductive health, yet there has been no research focusing on newborns in South Russia. The purpose of this current study was to analyze the levels of vitamin D in newborns in the Stavropol Region. The clinical, anamnestic, and laboratory examination involved 60 newborns. The levels of vitamin D were assessed based on serum content of calcidiol, while the mothers' pregnancy courses were also taken into account. The mean content of serum 25(ОН)D 3 was 9.9±0.7 ng/ml. The study showed that the vast majority of the patients (98.3%) lacked vitamin D while in over a half of them (56.7%) the deficiency was severe. It was shown that complicated somatic, obstetric and gynecological history is an important factor for antenatal hypovitaminosis D in newborns (р<0.05). In case of mothers' taking multivitamin preparations through pregnancies, severe vitamin D deficiency in newborns had an occurrence twice below that in infants whose mothers failed to take additional vitamin supply (р<0.001). There is confirmation to the need for targeted antenatal prevention of hypovitaminosis D in order to reach proper levels of calciferol in the early neonatal period. Key words: vitamin D, newborn, hypovitaminosis d, pregnancy failure, antenatal prophylaxisВитамин D оказывает широкий спектр биологических эффектов. Имеются данные, указываю-щие на значимую роль витамина D в репродуктивном здоровье женщин, но до настоящего времени показатели у новорожденных юга России не изучались. Целью исследования был анализ обеспе-ченности витамином D новорождённых детей Ставропольского края. Проведено клинико-анамне-стическое и лабораторное обследование 60 новорождённых. Обеспеченность витамином D оце-нивалась по содержанию кальцидиола в сыворотке крови, из анамнестических данных подробно анализировалось течение беременности у матери. Среднее содержание 25(ОН)D 3 сыворотки со-ставляло 9,9±0,7 нг/мл. Установлено, что у подавляющего большинства пациентов (98,3%) имеет место недостаточное содержание витамина D, более половины (56,7%) страдают тяжёлым дефи-цитом. Показано, что осложнённый соматический и акушерско-гинекологический анамнез являет-about authors:Karpov Sergey Mikhailovich, MD, Professor, head of Department of neurology, neurosurgery, medical genetics,

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Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Cited by 77 publications

References 32 publications

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Vitamin D levels in newborns children of Stavropol Region

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