Occult hepatitis B in renal transplant patients

Peres, Alessandro Afonso; Dias, Eduardo; Chesky, Marisa; Álvares‐da‐Silva, Mário Reis; Jobim, L.F.; Gonçalves, Luiz Felipe Santos; Manfro, Roberto Ceratti

doi:10.1111/j.1399-3062.2005.00091.x

Cited by 14 publications

(11 citation statements)

References 27 publications

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“…Serological markers of HBV infection were not detected in either of these patients. The primary finding of the present study was a very low prevalence of OHB among kidney transplant recipients (1%), as previously observed in two similar studies, one by Peres et al (2005) and the other by Bae et al (2012); these studies found prevalence of 2% and 2.7%, respectively. The demographic and laboratory data for the OHB infection patients are shown in Table II .…”

supporting

confidence: 89%

“…Peres et al (2005) used a nested PCR with a limit of detection of 104 copies/mL, whereas in the present study and the study by Bae et al (2012), the RT-PCR assays had lower limits of detection of 3 IU/mL (16 copies/mL) and 2 IU/mL (11 copies/mL), respectively. It is important to use a PCR assay with a low limit of detection because the VL is usually lower than 200 IU/mL (1000 copies/ml) in OHB patients according to Raimondo et al (2008) .…”

mentioning

confidence: 58%

“…Current evidence indicates that there is a high prevalence of OHB infection among dialysis patients (Altindis et al 2007, Aghakhani et al 2010, Motta et al 2010, Sav et al 2010); however, the prevalence of OHB infection among kidney transplant recipients remains controversial, with few published data on this subject (Peres et al 2005, Bae et al 2012). …”

mentioning

confidence: 99%

“…The 207 kidney transplant recipients included in this study were similar, with respect to the distributions of age, gender and time on dialysis, to the patient populations used in the studies by Peres et al (2005) and Bae et al (2012) . Peres et al (2005) used a nested PCR with a limit of detection of 104 copies/mL, whereas in the present study and the study by Bae et al (2012), the RT-PCR assays had lower limits of detection of 3 IU/mL (16 copies/mL) and 2 IU/mL (11 copies/mL), respectively.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of occult hepatitis B virus infection in kidney transplant recipients

Franz¹,

Perez²,

Zalis³

et al. 2013

Mem. Inst. Oswaldo Cruz

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In this cross-sectional study, 207 hepatitis B surface antigen (HBsAg)-negative kidney transplant recipients were evaluated based on demographic and epidemiological data and on the levels of serological markers of hepatitis B virus (HBV) and hepatitis C virus infection and liver enzymes. Patients with HBV or human immunodeficiency virus infection were excluded. Sera were analysed for the presence of HBV-DNA. HBV-DNA was detected in two patients (1%), indicating occult hepatitis B (OHB) infection (the HBV-DNA loads were 3.1 and 3.5 IU/mL in these patients). The results of the liver function tests were normal and no serological markers indicative of HBV infection were detected. The prevalence of OHB infection was low among kidney transplant recipients, most likely due to the low HBsAg endemicity in the general population of the study area.

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supporting

confidence: 89%

mentioning

confidence: 58%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of occult hepatitis B virus infection in kidney transplant recipients

Franz¹,

Perez²,

Zalis³

et al. 2013

Mem. Inst. Oswaldo Cruz

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“…Estudos comprovaram a existência de alta prevalência da IOB entre dialisados, entretanto a prevalência de IOB entre receptores de transplante renal é controversa 27,28,29,30,31,32 28,29 .…”

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Infecção oculta pelo vírus da hepatite B em comunidade amazônica submetida a intenso fluxo migratório, estado do Pará, Brasil

Nunes¹,

Soares²,

Sarmento³

et al. 2017

Revista Pan-Amazônica de Saúde

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The ones anti-HBc total+ isolated were selected, and from these the HBV DNA was investigated to identify OBI presence. RESULTS: In relation to HBV, the study showed 0.5% of carriers, 8.3% with a previous infection profile, 1.1% with a previous or current infection profile, and 33.6% with a vaccine response, characterizing that municipality as low endemicity for this virus. HBV DNA was detected in 66.7% of the HBsAg+ samples, with viral load between < 55 IU/mL and > 38,000 IU/mL; 69.2% of these samples were A1 subgenotype, 15.4% F2, and 15.4% F4. Of the total, 1.1% were samples from individuals anti-HBc total+ isolated whose molecular biology tests showed that 9.3% had HBV DNA, with viral load between < 15 IU/mL and 48 IU/mL. CONCLUSION: The findings of this study indicated the presence of OBI carriers in 0.1% of the Juruti population. The low prevalence of OBI found is probably related to the low endemicity of HBV in this population.

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Hepatitis B and C in Non–Liver Transplant Patients

Conjeevaram¹,

Lok²

2012

Zakim and Boyer's Hepatology

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Occult hepatitis B in renal transplant patients

Abstract: We found that occult HB is a condition present in our population of renal transplant patients and that HCV infection does not seem to be associated with occult HB infection in this setting.

Cited by 14 publications

References 27 publications

Prevalence of occult hepatitis B virus infection in kidney transplant recipients

Prevalence of occult hepatitis B virus infection in kidney transplant recipients

Infecção oculta pelo vírus da hepatite B em comunidade amazônica submetida a intenso fluxo migratório, estado do Pará, Brasil

Hepatitis B and C in Non–Liver Transplant Patients

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