Infecção oculta pelo vírus da hepatite B em comunidade amazônica submetida a intenso fluxo migratório, estado do Pará, Brasil

Abstract

The ones anti-HBc total+ isolated were selected, and from these the HBV DNA was investigated to identify OBI presence. RESULTS: In relation to HBV, the study showed 0.5% of carriers, 8.3% with a previous infection profile, 1.1% with a previous or current infection profile, and 33.6% with a vaccine response, characterizing that municipality as low endemicity for this virus. HBV DNA was detected in 66.7% of the HBsAg+ samples, with viral load between < 55 IU/mL and > 38,000 IU/mL; 69.2% of these samples were A1 subgenotype, 15.4% F2, and 15.4% F4. Of the total, 1.1% were samples from individuals anti-HBc total+ isolated whose molecular biology tests showed that 9.3% had HBV DNA, with viral load between < 15 IU/mL and 48 IU/mL. CONCLUSION: The findings of this study indicated the presence of OBI carriers in 0.1% of the Juruti population. The low prevalence of OBI found is probably related to the low endemicity of HBV in this population.

Detection and Genetic Characterization of Hepatitis B and D Viruses: A Multi-Site Cross-Sectional Study of People Who Use Illicit Drugs in the Amazon Region

“…A1, D3, and D4 had the highest frequencies, and a diversity of other subgenotypes recorded in Brazil and in other South American and Central American countries were detected in PWUDs. The high frequency of the A1 subgenotype is consistent with epidemiological studies conducted in Brazil [ 41 , 42 , 67 , 68 , 69 , 70 ]. Subgenotypes D4, D3, and D2 were identified in PWUDs and have already been detected in people from Brazilian states in the Amazon region, such as Amazonas (D3 and D4), Rondônia, and Roraima (D2, D3, D4), but with different frequencies [ 29 , 69 , 70 ].…”

“…To date, the presence of HDV in PWUDs has not yet been reported. In addition, the presence of occult HBV infection (OBI) has been recorded in the Amazon region, including in PWUDs [ 13 , 37 , 40 , 41 , 42 ]. OBI is defined as HBsAg-negative and anti-HBc positive/negative with HBV DNA detectable in serum and liver tissue.…”