Occult community acquired Klebsiella pneumoniae purulent meningitis in an adult

Abstract

Rationale:Klebsiella pneumonia (K. pneumonia), primarily a hospital-acquired pathogen, can cause a variety of deep-seated infections with significant morbidities. However, in the current scenario of global rise in antibiotic abuse, unexpected infection could be caused by K. pneumoniae.Patient concerns:A 56-year-old male who presented with intermittent headache and low fever was admitted, he had transsphenoidal surgery for pituitary adenoma 3 years ago. Routine laboratory tests revealed an elevated WBC count of 10.12 × 109/L and C-reactive protein (CRP) 12.9 mg/L. computed tomography (CT) revealed the sellar region with suspicious hemorrhage.Diagnoses:The patient was initially diagnosed with acute residual tumor hemorrhage. But the consequent diagnose of Klebsiella pneumoniae purulent meningitis was made based on the cerebrospinal fluid lab test and cerebrospinal fluid (CSF) and blood culture, and CT scan.Interventions:Lumbar puncture examination was made and the antibiotics were adjusted to meropenem and vancomycin according to the antibiotic sensitivity test. But because of the patient's unstable vital signs, his family refuse further lateral ventricular drainage.Outcomes:The infection was out of control and the patient died of spontaneous breath and heartbeat arrest.Lessons:Through this case, we could learn that any clue of suspicious intracranial infection should be carefully considered in the current scenario of global rise in antibiotic abuse. The manifestation of intermittent headache and mild fever could be potential signs of fatal infection, and prompt appropriate measures should be taken timely.

Left eye enucleation caused by multi-systemic Klebsiella pneumoniae invasive syndrome

“…Concerning treatment during hospitalization, timely abscess puncture and drainage will help relieve the condition and facilitate patient recovery. 13 In general, our patient did not pay attention to the first signs of her disease. When the condition had progressed to the point of irreversibility, she visited a hospital, but she was treated with conventional treatments that did not correct IKPLAS.…”

“…Concerning treatment during hospitalization, timely abscess puncture and drainage will help relieve the condition and facilitate patient recovery. 13 …”

Whole-Genome Analysis of KPC-Producing Klebsiella Pneumoniae Isolates From Hospital Acquired Post-Neurosurgical Meningitis

“…Bacterial meningitis in hospitals, especially intracranial infections caused by bacteria which resistant to carbapenems, is a life-threatening complication in neurosurgery patients [20,21]. The most common pathogen of hospital-associated meningitis is Staphylococcus, and Gram-negative bacteria with multidrug resistance and extensive drug resistance, including Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae; CRKP is rarely isolated from CSF samples [12,13,22,23]. Nevertheless, in many countries, including Turkey, the United States and China, meningitis caused by CRKP neurosurgery has been reported [13,[23][24][25].…”

Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases

“…The most common sites of CRKP infection are the respiratory system, urinary tract and bloodstream. CRKP is rarely isolated from CSF samples 4 , 5 , 14 .…”