Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study

Ikebe, Kazunori; Gondo, Yasuyuki; Kamide, Kei; Masui, Yukie; Ishizaki, T.; Arai, Yasumichi; Inagaki, Hiroki; Nakagawa, Toshio; Kabayama, Mai; Ryuno, Hirochika; Okubo, Hitomi; Takeshita, Hitoshi; Inomata, Chisato; Kurushima, Yuko; Mihara, Yusuke; Hatta, Kohdai; Fukutake, Motoyoshi; Enoki, Kaori; Ogawa, Taiji; Matsuda, Ken; Sugimoto, Ken; Oguro, Ryosuke; Takami, Yoichi; Itoh, Noriyuki; Takeya, Yasushi; Yamamoto, Kōichi; Rakugi, Hiromi; Murakami, Shinya; Kitamura, Masahiro; Maeda, Yoshinobu

doi:10.1371/journal.pone.0190741

Cited by 48 publications

(52 citation statements)

References 34 publications

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“…However, only a limited number of studies have examined the association between cognitive function and oral motor function with risk factors taken into consideration (Ikebe et al, 2018;Watanabe et al, 2018). As such, this study is the first to examine the association between cognitive function and multiple oral motor functions in older people with either normal cognitive function or mild cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between mild cognitive decline and oral motor functions in metropolitan community-dwelling older Japanese: The Takashimadaira study

Kugimiya

Ueda

Watanabe

et al. 2019

Archives of Gerontology and Geriatrics

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Background: Diminished oral motor function is considered to be a factor influencing cognitive decline, but this association has not been clarified. The aim of the present study was to clarify the association between cognitive and oral motor function in older people with either from normal cognitive function or mild cognitive decline. Methods: A cross-sectional study was conducted across 1,118 older people (445 men, 673 women) aged ≥70 years (mean age, 77.0 ± 4.7 years) who lived in a city of Tokyo Metropolis, Japan. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Older people who had an MMSE score of 23 points or lower were excluded. To investigate the relationship between cognitive and oral motor function, Pearson's correlation, multiple linear regression, and path analysis were performed. Results: Pearson's correlation revealed that, among the oral motor functions assessed, masticatory performance, occlusal force, and tongue pressure were correlated with MMSE score. Multiple linear regression showed that tongue pressure and oral diadochokinesis (ODK) were significantly associated with MMSE score. Path analysis revealed that decreases in tongue pressure and in ODK were directly associated with decreases in MMSE score. Decreases in tongue pressure were also indirectly 2 associated with decreases in MMSE score via decreases in ODK. Conclusions: Among the oral motor functions assessed, tongue pressure and ODK were associated with cognitive function in older people ranging from those with normal cognitive function to those with mild cognitive decline. Diminished tongue pressure and ODK might thus lead to cognitive decline.

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Section: Discussionmentioning

confidence: 99%

“…Similarly, Ikebe et al reported that decreased occlusal force might lead to decreased cognitive function (Ikebe et al, 2018). These reports suggested that oral motor function was associated with cognitive function.…”

Section: Introductionmentioning

confidence: 94%

Relationship between mild cognitive decline and oral motor functions in metropolitan community-dwelling older Japanese: The Takashimadaira study

Kugimiya

Ueda

Watanabe

et al. 2019

Archives of Gerontology and Geriatrics

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“…To evaluate the influence of rs650439 genotype on plasma klotho concentration, we collected blood samples of 70 ± 1 year-old community-dwelling adults in Japan who participated in the SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians) study [30–36]. Initially, genotypes of rs650439 were determined using the TaqMan SNP genotyping assay (Applied Biosystems Japan, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration

Yokoyama

Oguro

Yamamoto

et al. 2018

Aging

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Klotho protects against development of multiple age-related disorders, including cardiovascular diseases. We assessed whether a human klotho single nucleotide polymorphism (SNP) rs650439 is associated with the onset of stroke in hypertensive patients and plasma klotho concentration in the general population. Five hundred and twenty-three patients with hypertension were analyzed for both the presence of rs650439 and onset of stroke. We found that hypertensive patients with the TT genotype of rs650439 (n=52) had a higher incidence of stroke than those with AT (n=257) and AA (n=214) genotypes. Multivariate analysis indicated that the TT genotype was the only risk factor associated with increased incidence of stroke. Plasma klotho concentrations were measured in a general population (age=70±1 years) to assess the association between rs650439 and plasma klotho concentration. A significant trend was observed in the elderly population where plasma klotho concentration decreased as the T alleles in rs650439 increased. Subjects with a TT genotype had lower plasma klotho concentrations than those with AT+AA genotypes. In conclusion, TT genotype of klotho SNP (rs650439) is correlated with an increased incidence of stroke in hypertensive patients, and the mechanism underlying this correlation might involve the effect of rs650439 T allele on plasma klotho concentrations.

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“…Epidemiologic studies have suggested associations between cognitive ability and oral conditions, such as number of teeth (Luo et al, 2015;Li et al, 2017;Oh et al, 2018) and dental occlusion (Ono et al, 2010;Franco et al, 2012;Takeuchi et al, 2015). Furthermore, occlusal force (Takeshita et al, 2016;Ikebe et al, 2018) and chewing ability have been shown to have effects on cognitive ability (Chen et al, 2015;Natalie et al, 2015;Seraj et al, 2017). Oral reconstruction by means of wearing a denture may induce cortical activation in prefrontal, sensorimotor, and sensory association cortices during chewing performance (Kimoto et al, 2011;Kamiya et al, 2016) and might also contribute to antiaging cognitive activation in the prefrontal cortex of elderly edentulous patients (Banu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal Consolidation and Compensation as a Function of Wearing Denture in Partially Edentulous Elderly Patients

Narita

Ishii

Iwaki

et al. 2020

Front. Aging Neurosci.

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Background: The cognitive effects of wearing a denture are not well understood. This study was conducted to clarify the effects of denture use on prefrontal and chewing muscle activities, occlusal state, and subjective chewing ability in partially edentulous elderly individuals.Methods: A total of 16 partially edentulous patients were enrolled. Chewing-related prefrontal cortex and jaw muscle activities were simultaneously examined using a functional near-infrared spectroscopy (fNIRS) device and electromyography, under the conditions of unwearing, and wearing a denture. Occlusal state and masticatory score were also determined under both conditions. Using multiple linear regression analysis, associations between prefrontal and chewing activities with wearing were examined using change rates.Results: Chewing rhythmicity was maintained under both conditions. As compared with unwearing, the wearing condition was associated with improved prefrontal cortex and chewing muscle activities, occlusal state in regard to force and area, and masticatory score. Also, prefrontal activities were positively associated with burst duration and peak amplitude in masseter (Mm) and temporal muscle activities, as well as masticatory scores. In contrast, prefrontal activities were negatively associated with occlusal force. Conclusion:Wearing a denture induced a positive association between burst duration and peak amplitude in Mm and temporal muscle activities and prefrontal activity, which may indicate a parallel consolidation of prefrontal cortex and rhythmical chewing activities, as well as masticatory scores. On the other hand, denture use induced a negative association of occlusal force with prefrontal activities, which might suggest that prefrontal compensative associations for the physiocognitive acquisition depended on biomechanical efficacy gained by wearing a denture.

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Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study

Cited by 48 publications

References 34 publications

Relationship between mild cognitive decline and oral motor functions in metropolitan community-dwelling older Japanese: The Takashimadaira study

Relationship between mild cognitive decline and oral motor functions in metropolitan community-dwelling older Japanese: The Takashimadaira study

A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration

Prefrontal Consolidation and Compensation as a Function of Wearing Denture in Partially Edentulous Elderly Patients

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