Obtaining rapid and effective hemostasis

Howe, Nicole; Cherpelis, Basil S.

doi:10.1016/j.jaad.2013.07.014

Cited by 69 publications

(84 citation statements)

References 111 publications

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“…Haemostasis can be achieved using pressure, aluminium chloride 20% in alcohol ('Driclor'), aluminum sulphate in aqueous solution ('Stingose'), or electrocauterisation. 12,13 Caution is advised when using electrocauterisation subsequent to aluminum chloride in alcohol due to its flammable nature.…”

Section: Shave Biopsymentioning

confidence: 99%

Improving diagnostic accuracy of skin biopsies

Stevenson¹,

Rodins²

2018

Aust J Gen Pract

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Section: Shave Biopsymentioning

confidence: 99%

Improving diagnostic accuracy of skin biopsies

Stevenson¹,

Rodins²

2018

Aust J Gen Pract

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“…Risk of irritation and pain; should not be used for wounds that require closure (Howe & Cherpelis, 2013) …”

Section: Aluminum Chloride (Drysol)mentioning

confidence: 99%

“…In clinical practice, aluminum chloride is a commonly used caustic agent. Caustic agents are substances that cause thrombus and occlusion of small vessels through the destruction of tissue, leading to protein precipitation and coagulation (Howe & Cherpelis, 2013). As a caustic agent, aluminum chloride causes hydrolysis of hydrogen chloride, leading to the activation of the extrinsic coagulation pathway, tissue coagulation, and vasoconstriction (Larson, 1988).…”

mentioning

confidence: 99%

Aluminum Chloride

Totri

Jacob

2015

Journal of the Dermatology Nurses' Association

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By definition, a drug is a medicine or substance that exerts a physiologic affect on an organism. In dermatology, medications and substances are utilized on a daily basis from topical treatments to anesthetics in micrographic surgery. The purpose of this column is to focus on some of the more common drugs used in dermatology, specifically their mechanism of action and routine alternatives (if available). This brief focuses on the utilization of aluminum chloride in dermatologic hemostasis and provides a table of alternative caustic agents used for hemostasis.

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“…Various methods used in dermatologic surgery to promote hemostasis include surgical procedures such as anesthetic techniques, electrosurgery, manual pressure, and adjunctive topical agents. 4 , 7 Topical hemostatic agents are commonly classified as caustic (e.g., aluminum chloride, ferric sulfate, silver nitrate, and zinc chloride paste) or noncaustic. 4 Noncaustic agents, such as porcine gelatins, microporous polysaccharide spheres, hydrophilic polymers with potassium salts, oxidized regenerated cellulose, and microfibrillar collagens may work physically, or physiologically, for example, fibrin sealants, thrombin, and platelet gels.…”

mentioning

confidence: 99%

“…Other concerns include animal/human sourcing, antibody formation, infection, and handling restrictions. 4 , 7 , 8 Some materials, such as silver, have been shown to be effective at eluting active agents to ameliorate the microenvironment and reduce the infection rate. However, the safety and tolerability of active agents remains in question.…”

mentioning

confidence: 99%

First Safety and Performance Evaluation of T45K, a Self-Assembling Peptide Barrier Hemostatic Device, After Skin Lesion Excision

Rahmani

Prats²,

Norchi³

et al. 2018

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BACKGROUNDThe self-assembling peptide barrier T45K (SAPB-T45K) is an oligopeptide that rapidly forms a biocompatible hemostatic barrier when applied to wounds.OBJECTIVEEvaluate safety and performance of SAPB-T45K in cutaneous surgery.MATERIALS AND METHODSIn this single-blind study, after sequential shave excision of 2 lesions, wounds were randomized (intrapatient) to SAPB-T45K or control treatment. Safety was assessed at treatment, Day 7, and Day 30. Performance was evaluated using time to hemostasis (TTH) and ASEPSIS wound scores, with a subgroup analysis for patients with or without antiplatelet therapy.RESULTSEach of 46 patients (10 [22%] with antiplatelet therapy) received randomized SAPB-T45K or control treatment for 2 wounds. Safety assessments were similar, and ASEPSIS scores reflected normal healing in both wound groups. SAPB-T45K demonstrated significantly faster median TTH (24.5 [range, 7–165] seconds) compared with control (44 [10–387] seconds), for a 41% median TTH reduction (18 [95% confidence interval, 7–35] seconds, p < .001). SAPB-T45K provided an identical median TTH of 24 seconds, regardless of antiplatelet therapy. Control median TTH was 90 and 40 seconds for patients taking or not taking antiplatelet therapy, respectively.CONCLUSIONSSAPB-T45K provided significantly faster median TTH versus control, especially with antiplatelet therapy, and safety profiles were similar.

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Obtaining rapid and effective hemostasis

Cited by 69 publications

References 111 publications

Improving diagnostic accuracy of skin biopsies

Improving diagnostic accuracy of skin biopsies

Aluminum Chloride

First Safety and Performance Evaluation of T45K, a Self-Assembling Peptide Barrier Hemostatic Device, After Skin Lesion Excision

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