Obtaining a high-activity strain capable of producing the antistaphylococcal antibiotic batumin

Biosynthesis of polyketides by trans-AT polyketide synthases

“…96,97 A short time later the isolation of the antibiotic batumin (7) was reported from Pseudomonas batumici. 98 The bat gene cluster (BGC0001099) was eventually discovered in another pseudomonad (P. uorescens BCCM_ID9359) by Lavigne and co-workers. 99 All three bacteria produce polyketides with the same chemical composition.…”

Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics

“…A short time later the antibiotic batumin was isolated from Pseudomonas batumici and found to have the same molecular weight and spectroscopic properties as kalimantacin A. 6 , 7 Batumin has been patented in the Ukraine and formulated as Diastaf and used to detect staphylococci by taking advantage of its selectivity for these strains. 8 Decreased biofilm formation has also been reported for the majority of S. aureus strains investigated 9 and it has been found to reduce nasal S. aureus carriage.…”

Control of β‐Branching in Kalimantacin Biosynthesis: Application of 13C NMR to Polyketide Programming

“…Its full structure and stereochemistry were determined by a combination of degradation and stereoselective synthesis of the resulting fragments . This study also confirmed that kalimantacin and batumin, which was isolated from Pseudomonas batumici , are the same compound . It is produced by a hybrid type I trans ‐acyltransferase (AT) polyketide synthase (PKS)/non‐ribosomal peptide synthase (NRPS) .…”