Obstructive Sleep Apnea

Caples, Sean M.; Gami, Apoor S.; Somers, Virend K.

doi:10.7326/0003-4819-142-3-200502010-00010

Cited by 392 publications

(270 citation statements)

References 87 publications

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“…Obstructive sleep apnea (OSA), a very common breathing and sleep disorder, is associated with intermittent hypoxia (IH) resulting from upper airway obstruction of structural or neural causes [1,2] . The most distinct features of OSA are episodes of oxyhemoglobin desaturations, which are terminated by brief periods of microarousals that could lead to sleep deprivation, fragmentation and alteration in sleep pattern [3] .…”

Section: Introductionmentioning

confidence: 99%

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Xie

Yung

2012

Acta Pharmacol Sin

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Obstructive sleep apnea (OSA) is well known for its metabolic as well as neurobehavioral consequences. Chronic intermittent hypoxia (IH) is a major component of OSA. In recent years, substantial advances have been made in elucidating the cellular and molecular mechanisms underlying the effect of chronic IH on neurocognitive functions, many of which are based on studies in animal models. A number of hypotheses have been put forward to explain chronic IH-induced neurological dysfunctions. Among these, the roles of oxidative stress and apoptosis-related neural injury are widely accepted. Here, focusing on results derived from animal studies, we highlight a possible role of reduced expression of brain-derived neurotrophic factor (BDNF) in causing impairment in long-term synaptic plasticity and neurocognitive functions during chronic IH. The possible relationship between BDNF and previous findings on this subject will be elucidated.

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Section: Introductionmentioning

confidence: 99%

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Xie

Yung

2012

Acta Pharmacol Sin

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“…A apnéia é definida como a interrupção total do fluxo aéreo por intervalo 10s e a hipopnéia é a interrupção parcial ( 50%) do fluxo aéreo. Ambas devem estar associadas à queda da saturação da hemoglobina de, no mínimo, 4% e/ou ao despertar do paciente (3,4). De acordo com a classificação, considerase: a) AOS leve: 5 > IAH < 15 eventos por hora; b) AOS moderada: 15 > IAH < 30 eventos por hora: c) AOS grave: IAH > 30 eventos por hora (5,6).…”

Section: Introductionunclassified

Contribuição da apnéia obstrutiva do sono para o estresse oxidativo da obesidade

Lima

Franco

Castro

et al. 2008

Arq Bras Endocrinol Metab

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RESUMOObjetivo: O objetivo do trabalho foi verificar a influência da apnéia obstrutiva do sono (AOS) sobre o estresse oxidativo da obesidade e o efeito do pressão positiva de vias aéreas (CPAP) nestes pacientes. Métodos: Os pacientes com IMC 30 kg/m 2 foram divididos em: a) grupo 1: dez indivíduos sem AOS; b) grupo 2: dez portadores de AOS que não fizeram o uso do CPAP; e c) grupo 3: nove portadores de AOS que fizeram uso do CPAP durante dois meses. Resultados: O grupo 3 apresentou, após o uso do CPAP, redução na produção de superóxido (SO) [13,2 (10,3-19,6) versus 10,5 (5,8-11,8) ABSTRACTObstructive Sleep Apnea Contribution to Oxidative Stress in Obesity. Objective: The aim of this paper was to check the influence of obstructive sleep apnea (OSA) on obesity oxidative stress and CPAP (Continuous Positive Airway Pressure) effect on oxidative stress and in these patients. Methods: Twenty nine male patients considered obese (BMI 30kg/m 2 ) were divided into 3 groups: a) Group I: 10 OSA free patients (apnea-hipopnea index (AHI) 5); b) Group 2: 10 with moderate to serious OSA (AHI 20); c) Group 3: 9 with OSA from moderate to serious (AHI 20) using CPAP,, minimum 4 hours/ night for 2 months. Results: Significant differences before and after CPAP usage were observed in group 3 in the following variables: reduction of superoxide (SO) production [13,2 (10,3-19,6) vs. 10,5 (5,8-11,8) nmoles O 2 -/2x106 PMN] and increase in serum nitrite/nitrates levels [24,5 (16,7-33,5) vs. 49,5 (39,3-58,1) M]. Positive correlation between Apnea-Hypopnea Index (AHI) and SO (r = 0,726) and negative correlation was observed between AHI and serum nitrite/nitrates levels (r = 0,867

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“…It is estimated that one of five white adults has at least mild disease and one of 15 has at least moderate disease (Caples et al, 2005). There is a graded increase in OSA prevalence with increasing body mass index (BMI) and waist to hip ratio.…”

Section: Introductionmentioning

confidence: 99%

The effect of an increased intake of vegetables and fruit on weight loss, blood pressure and antioxidant defense in subjects with sleep related breathing disorders

et al. 2007

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Objective: To assess the effect of an increased consumption of vegetables and fruit on body weight, risk factors for cardiovascular disease (CVD) and antioxidant defense in obese patients with sleep-related breathing disorders (SRBD). Design: Randomized, controlled trial of an intervention to increase the intake of vegetables to 400 g/day and fruit to 300 g/day. Dietary intake was calculated from a food frequency questionnaire. Antioxidant status was assessed with the ferric-reducing/ antioxidant power (FRAP) assay. Plasma carotenoids were biomarkers for the intake of vegetables and fruit. Setting: A hospital clinic preventing risk factors for CVD. Subjects: Subjects were 103 men and 35 women with a body mass index of 36.775.8 kg/m 2 of which 57 (86%) in the control and 68 (94%) in the intervention group completed the study. Intervention: Group-based behavioral program during 3 months. Results: The mean between group differences in body weight was À2.0% (95% CI À3.6, À0.5), Po0.0001. The mean between group difference in systolic and diastolic blood pressure (BP) was À7.1 mm Hg (95% CI: À11.6, À2.6), P ¼ 0.0022 and À3.9 mm Hg (95% CI: À7.0, À0.9), P ¼ 0.0120, respectively. The mean change in daily intake of vegetables and fruit was 12 g (95% CI: À33, 57) and À4 g (95% CI: À79, 71) versus 245 g (95% CI: 194, 296) and 248 g (95% CI: 176, 320) in the control and intervention groups, respectively. This was reflected in higher concentrations of a-carotene and b-carotene. No change in FRAP was seen. In a multiple regression analysis the change in intake of vegetables was a significant contributor (R adj 2 ¼ 0.073 (95% CI: 0.019, 0.214)) to the change in weight. Conclusion: Targeted dietary advice to increase the intake of vegetables and fruit among subjects with SRBD contributed to weight reduction and reduced systolic and diastolic BP, but had no effect on antioxidant defense measured with FRAP. Sponsorship: None.

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Obstructive Sleep Apnea

Cited by 392 publications

References 87 publications

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Contribuição da apnéia obstrutiva do sono para o estresse oxidativo da obesidade

The effect of an increased intake of vegetables and fruit on weight loss, blood pressure and antioxidant defense in subjects with sleep related breathing disorders

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