Obstructive Sleep Apnea Syndrome as First Manifestation of Pharyngeal Non-Hodgkin’s Lymphoma

Gómez-Merino, Elia; Arriero, J.M.; Chiner, Eusebi; Signes-Costa, Jaime; Marco, J.

doi:10.1159/000068423

Cited by 14 publications

(16 citation statements)

References 6 publications

(7 reference statements)

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“…Pain, xerostomia, and depression as well as smoking and problem drinking have been associated with decreased sleep among head and neck cancer patients (44). Sleep apnea related to obesity or airway obstruction resulting from complications of head and neck cancer should also be evaluated (40–42). …”

Section: Discussionmentioning

confidence: 99%

“…(40). Airway obstruction in these patients can instead be caused by the tumor physically blocking or compressing the airway (41, 42), stenosis of the upper aero-digestive tract resulting from tumor resection, or reconstruction of a surgical defect (40). Radiation therapy to treat head and neck tumors can also create edema, fibrosis or alterations in physiology leading to airway obstruction (43).…”

Section: Introductionmentioning

confidence: 99%

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Health Behaviors Predict Higher Interleukin-6 Levels among Patients Newly Diagnosed with Head and Neck Squamous Cell Carcinoma

Duffy

Teknos

Taylor

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Health behaviors have been shown to be associated with recurrence risk and survival rates in cancer patients and are also associated with Interleukin-6 levels, but few epidemiologic studies have investigated the relationship of health behaviors and Interleukin-6 among cancer populations. The purpose of the study is to look at the relationship between five health behaviors: smoking, alcohol problems, body mass index (a marker of nutritional status), physical activity, and sleep and pretreatment Interleukin-6 levels in persons with head and neck cancer. Methods Patients (N=409) were recruited in otolaryngology clinic waiting rooms and invited to complete written surveys. A medical record audit was also conducted. Descriptive statistics and multivariate analyses were conducted to determine which health behaviors were associated with higher Interleukin-6 levels controlling for demographic and clinical variables among newly diagnosed head and neck cancer patients. Results While smoking, alcohol problems, body mass index, physical activity, and sleep were associated with Interleukin-6 levels in bivariate analysis, only smoking (current and former) and decreased sleep were independent predictors of higher Interleukin-6 levels in multivariate regression analysis. Covariates associated with higher Interleukin-6 levels were age and higher tumor stage, while comorbidities were marginally significant. Conclusion Health behaviors, particularly smoking and sleep disturbances, are associated with higher Interleukin-6 levels among head and neck cancer patients. Impact Treating health behavior problems, especially smoking and sleep disturbances, may be beneficial to decreasing Interleukin-6 levels which could have a beneficial effect on overall cancer treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Health Behaviors Predict Higher Interleukin-6 Levels among Patients Newly Diagnosed with Head and Neck Squamous Cell Carcinoma

Duffy

Teknos

Taylor

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The association of OSAS with tumours of the neck is not frequent (6,7). In all reported cases the neck tumour caused a reduction of posterior airway space, defined as the distance between tongue base and posterior pharynx wall, that is the most important predictive parameter of OSAS (1).…”

Section: Discussionmentioning

confidence: 99%

Mycosis Fungoides as a Cause of Severe Obstructive Sleep Apnea

et al. 2011

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We report the case of a 38-year-old woman, affected by a cutaneous form of mycosis fungoides (MF) who presented with a history of loud snoring associated with sleep apnea. A polysomnographic study confirmed the presence of severe obstructive sleep apnea syndrome (OSAS). Cranial and neck MRI revealed a neoplastic infiltration of the tongue base and the posterior pharynx wall. Upper airway neoplastic infiltration is rarely reported as a cause of OSAS and extra-cutaneous localizations of MF are uncommon. This is the first case in the literature of a patient with nocturnal polysomnogram documented OSAS caused by a mucosal involvement of MF.

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“…Si bien la sintomatología y el examen físico inicial sugerían SAOS, la poligrafía con un IAH extremo y la nasofibroscopia hicieron sospechar una neoplasia concomitante, con el hallazgo final de linfoma extranodal T/NK tipo nasal, una entidad no tan infrecuente en nuestro medio. Este reporte resalta la necesidad de considerar el SAOS como una presentación de tumores del tracto aerodigestivo, principalmente de linfomas no Hodgkin, según los casos clínicos reportados en la literatura [11][12][13] , así como de realizar un exhaustivo plan de trabajo que incluya una nasofibroscopia y una tomografía.…”

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