La papilomatosis laríngea recurrente es una enfermedad producida por el virus del papiloma humano, que produce lesiones epiteliales exofíticas. En la actualidad, no existe un tratamiento definitivo, existiendo una gran recurrencia de las lesiones. Una de las alternativas promisorias es el uso de láser KTP con bevacizumab. No obstante, en nuestro medio, los hospitales no cuentan con láser KTP, utilizándose únicamente técnica en frío. Se presenta un caso clínico de papilomatosis laríngea recurrente con el uso de bevacizumab (avastin) a 16,5 mg/mL como terapia adyuvante a cirugía con técnica en frío.

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Introduction Olfactory dysfunction has been included among the early symptoms of coronavirus disease (COVID-19). Evidence suggests that a relationship exists between the duration of olfaction disorders and the probability of developing severe COVID-19. Given the scope of the COVID-19 pandemic, this study aimed to determine the frequency of smell alteration and its association with the severity of COVID-19 in a referral hospital in Peru, which is one of the most affected countries in the Latin American region. Materials and Methods This study was an observational, prospective cohort study that included patients with COVID-19 who were treated at the Hospital Nacional Edgardo Rebagliati Martins from August to November 2020. To assess the association, the chi-square test of independence or Fisher’s exact test was performed. The outcome variable was COVID-19 severity, and the exposure variable was olfactory dysfunction. The first data collection was in the emergency department and the follow-up was via telephone. Results A total of 179 patients were included. The mean age was 61.6 ± 15.5 years, and 129 patients (72.1%) were male. Olfactory dysfunction was observed in 43 patients (24%). An inverse association was found between age and olfactory dysfunction ( P = .002). No significant association was found between COVID-19 severity level and olfactory alteration ( P = .056). However, a direct association was found between COVID-19 severity and age ( P = .003), cough ( P < .001), and respiratory distress ( P = .003). Conclusion This study did not find any association between the severity of COVID-19 and olfactory dysfunction. It showed a low incidence rate of smell alteration compared with studies from other regions. Moreover, smell alteration was associated with younger age.

CI surgery in Peru is a safe procedure with a low frequency of major complications, representing an effective therapy for patients with sensorineural hearing loss who do not respond to hearing aids.

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