Obstructive sleep apnea is associated with fatty liver index, the index of nonalcoholic fatty liver disease

Chen, Xiao; Lin, Xian Hua; Chen, Li-Da; Lin, Qi‐Chang; Chen, Gongping; Yu, Yaohua; Huang, Jian-Chai; Zhao, Jianming

doi:10.1097/meg.0000000000000598

Cited by 15 publications

(9 citation statements)

References 31 publications

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“…Agrawal [49] , 2015 (India) Chen [37] , 2016 Qi [50] , Trzepizur [39] , 2018 -AHI and ODI were the factors with the strongest independent association with LSM Bhatt [42] , 2019 -OSA and NAFLD operate as an independent contributors to the increased systemic inflammation that occurs in overweight/obese subjects ALT: Alanine aminotransferase; AHI: Apnea-hypopnea index; APRI: Aspartate aminotransferase to platelet ratio index; AST: Aspartate aminotransferase; BMI: Body mass index; CPAP: Continuous positive airway pressure; CT: Computed tomography; FLI: Fatty liver index; LSM: Liver stiffness measurement; NAFLD: Non-alcoholic fatty liver disease; ODI: Oxygen desaturation index; OSA: Obstructive sleep apnea; PSG: Polysomnography; SpO 2 : Oxygen saturation.…”

Section: Patient Characteristics Resultsmentioning

confidence: 99%

“…Arisoy et al [41] observed that BMI and hepatosteatosis grade progressively and significantly increased from patients without OSA to those with severe OSA. Chen et al [37] found a positive association between the severity of OSA and NAFLD. In particular, the prevalence of NAFLD was 20.4% in patients with AHI < 15 whereas it reached 52.1% in patients with AHI ≥ 15.…”

Section: The Severity Of Nafld Is Associated With the Increase In Osamentioning

confidence: 98%

“…All the studies used PSG and AHI to diagnose OSA, according to the American Academy of Sleep Medicine (AASM) Clinical Practice Guideline [16] , except for two that used cardio-respiratory polygraphy [34,35] . In 7 studies NAFLD was diagnosed by abdominal ultrasound, in 4 studies by abdominal computed tomography [36] , fatty liver index (FLI) [37] , aspartate aminotransferase (AST) to platelet ratio index (APRI) [38] and elastography [39] , whereas only two studies used the gold standard liver biopsy [34,40] .…”

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Association between non-alcoholic fatty liver disease and obstructive sleep apnea

Umbro¹,

Fabiani²,

Fabiani³

et al. 2020

WJG

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show abstract

Section: Patient Characteristics Resultsmentioning

confidence: 99%

Section: The Severity Of Nafld Is Associated With the Increase In Osamentioning

confidence: 98%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Association between non-alcoholic fatty liver disease and obstructive sleep apnea

Umbro¹,

Fabiani²,

Fabiani³

et al. 2020

WJG

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“…Many clinical scores like NAS and SAF (steatosis, activity and fibrosis) are used for the diagnosis of NAFLD [ 50 , 51 ]. Non-invasive tools like fatty liver index, serum algorithm and elastography for diagnosis of NASH have been recently validated [ 51 - 56 ]. The clinical significance of NASH is that it is associated with varying degrees of fibrosis, extremes of which can progress to cirrhosis and hepatocellular carcinoma [ 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Concomitant Obstructive Sleep Apnea and Non-Alcoholic Steatohepatitis Treated With CPAP Therapy

Bajantri

Lvovsky

2018

Gastroenterol Res

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Obstructive sleep apnea syndrome is a disorder of sleep breathing that is a result of recurrent and intermittent hypoxia during sleep induced by the repeated partial or complete collapse of the upper airway, eventually causing chronic intermittent hypoxia. Non-alcoholic fatty liver disease is divided into non-alcoholic fatty liver and non-alcoholic steatohepatitis. Animal and human studies showed that obesity is associated with chronic liver hypoxia, even in the presence of systemic normoxia causing inflammation and release of cytokines. A “two-hit” model has been proposed. The first hit is characterized by insulin resistance and excess hepatic lipid accumulation secondary to abnormal fatty acid metabolism. Oxidative stress and inflammation are thought to comprise the second hit. Gold standard for the diagnosis of non-alcoholic steatohepatitis is a liver biopsy. Many clinical scores and non-invasive tools are used for the diagnosis of non-alcoholic steatohepatitis. Conservative management with lifestyle modifications including diet, exercise and weight loss remains the therapy of choice today. We present a case report of a 39-year-old man who was diagnosed with concomitant non-alcoholic steatohepatitis and severe obstructive sleep apnea. He was started treatment with continuous positive airway pressure and demonstrated excellent adherence to therapy for 6 years, with concomitant obstructive sleep apnea and non-alcoholic steatohepatitis which reversed with prolonged optimal continuous positive airway pressure therapy. Physical examination remained unremarkable except for morbid obesity. His abdominal girth, as well as body mass index, remained unchanged. After 6 years of optimal continuous positive airway pressure therapy, liver enzymes and relevant lipid panel normalized, suggesting reversal of non-alcoholic steatohepatitis.

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“…A zsírindex hasznos biológiai jelzője a NAFLD súlyosságának OSA-betegekben. Alacsony fokozatú gyulladás, oxidatív stressz és ectopiás zsírlerakódás közös jellemzői a krónikus obstruktív tüdőbetegségnek (COPD) is, és hozzájárulnak a NAFLD kialakulásához [64]. Viglino és mtsai validált, noninvazív módszereket alkalmaztak a steatosis, a NASH és a májfibrosis vizsgálatára.…”

Section: Obstruktív Alvási Apnoe/hypoventilatiós Szindrómaunclassified

A nem alkoholos zsírmáj mint a metabolikus szindróma komponense és kauzális kapcsolatai egyéb kórképekkel

Halmos¹,

Suba

2017

Orvosi Hetilap

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Non-alcoholic fatty liver disease is the most common non-infectious chronic liver-disease in our age, and is a spectrum of all the diseases associated with increased fat accumulation in the hepatocytes. Its development is promoted by sedentary life-style, over-feeding, and certain genetic predisposition. Prevalence in the adult population, even in Hungary is ~30%. In a part of cases, this disease may pass into non-alcoholic steatohepatitis, later into fibrosis, rarely into primary hepatocellular cancer. Fatty liver is closely and bidirectionally related to the metabolic syndrome and type 2 diabetes, and nowadays there is a general consensus that fatty liver is the hepatic manifestation of the metabolic sycndrome. The importance of the fatty liver has been highly emphasized recently. In addition to the progression into steatohepatitis, its causal relationship with numerous extrahepatic disorders has been discovered. In our overview, we deal with the epidemiology, pathomechanism of the disease, discuss the possibilities of diagnosis, its relationship with the intestinal microbiota, its recently recognized correlations with bile acids and their receptors, and its supposed correlations with the circadian CLOCK system. Hereinafter, we overview those extrahepatic disorders, which have been shown to be causal link with the non-alcoholic fatty liver disease. Among these, we emphasize the metabolic syndrome/type 2 diabetes, cardiovascular disorders, chronic kidney disease, sleep apnea/hypoventilation syndrome, inflammatory bowel disease, Alzheimer's disease, osteoporosis, and psoriasis, as well. Based on the above, it can be stated, that high risk individuals with non-alcoholic fatty liver disease need systemic care, and require the detection of other components of this systemic pathological condition. While currently specific therapy for the disease is not yet known, life-style changes, adequate use of available medicines can prevent disease progression. Promising research is under way, including drugs, manipulation of the intestinal flora or the possibility of therapeutic use of bile acid receptors, and also bariatric surgery. Orv Hetil. 2017; 158(52): 2051-2061.

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Obstructive sleep apnea is associated with fatty liver index, the index of nonalcoholic fatty liver disease

Abstract: Our results suggest a positive association between the severity of OSA and NAFLD defined by an elevated FLI, which may serve as a good biomarker for detecting NAFLD in OSA patients.

Cited by 15 publications

References 31 publications

Association between non-alcoholic fatty liver disease and obstructive sleep apnea

Association between non-alcoholic fatty liver disease and obstructive sleep apnea

A Case of Concomitant Obstructive Sleep Apnea and Non-Alcoholic Steatohepatitis Treated With CPAP Therapy

A nem alkoholos zsírmáj mint a metabolikus szindróma komponense és kauzális kapcsolatai egyéb kórképekkel

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