Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly

Abstract

OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR. The association between OS during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly.

Sixteen weeks of aerobic training influence spirometry, s-klotho, and hemodynamic responses to sub-maximal exercise testing in obese men with severe obstructive sleep apnea

“…Such improvement to heart rate were previously noted in the literature. 53,56 As in previous studies, the data of this study suggest a blunt response to exercise and during exercise, preventing people with OSA to function at levels common to age and sex matching healthy people. 53…”

Does obstructive sleep apnea affect exercise capacity and the hemodynamic response to exercise? An individual patient data and aggregate meta-analysis

“…Moreover, one study was not included [50] since the ClinicalTrials number was identical to a study already included in the meta-analysis [23] and another study was excluded [51] since the population characteristics were similar to those from a study previously published by the same author the same year [36]. In addition, three studies not reported by Mendelson et al were included in the present meta-analysis [35,36,49]. Despite no evident publication bias was experienced on the funnel plot, the high level of inconsistency assessed though I 2 and Cochran's Q test reported and the absence of adjustment for confounders in statistical analyses reduces the confidence of these results [52,53].…”

“…Two studies included in the IPD meta-analysis were conducted in the United States [30,33], two in Brazil [32, 34] and one in Europe [46]. Overall, four of the studies included in the AD meta-analysis were conducted in the United States [17,22,29,47], four in Brazil [31,35,48,49], four in Europe [28,36,37], and two in Taiwan [18,23].…”

Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?

“…Also, HRV kinetics during submaximal or maximal exercise may be predictive of aerobic fitness and exercise performance ( 96 ); (iii) Heart rate recovery represents reactivation of the parasympathetic tone, since vagal reactivation plays an integral part in reducing HR after exercise, especially during the first two minutes ( 88 ). For instance, heart rate recovery at two minutes was 23% lower in patients with sleep disorders comparted to healthy controls (35.5 vs. 46.5 bpm) ( 97 ). Similarly, HRV recovery following exercise occurs more rapidly in individuals with greater aerobic fitness ( 96 ).…”

“…A deteriorated resistance to objective fatigability [ A , adapted from ( 29 )] may lead to a greater functional decline for a given task and more time to recover from daily life activities. The tasks performed in daily life could induce an accumulation of fatigue over time ( B ) or, more likely, could lead the persons to reach their ceiling of subjective fatigue earlier in the day [ C , adapted from ( 97 )]. This may force them to enter in the vicious circle of fatigue.…”