2021
DOI: 10.3390/jcm10173785
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Abstract: Obstructive sleep apnea (OSA) is a highly prevalent disorder with a growing incidence worldwide that closely mirrors the global obesity epidemic. OSA is associated with enormous healthcare costs in addition to significant morbidity and mortality. Much of the morbidity and mortality related to OSA can be attributed to an increased burden of cardiovascular disease, including cardiac rhythm disorders. Awareness of the relationship between OSA and rhythm disorders is variable among physicians, a fact that can infl… Show more

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Cited by 8 publications
(5 citation statements)
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“…This was consistent with studies supporting OSA as the most prevalent secondary contributor to elevated blood pressure in patients with resistant hypertension [ 32 ]. Increased sympathetic activity, intrathoracic pressure during episodes of apnea resulting in hypertension, and excessive rates of venous return have been postulated as possible mechanisms for the development of AF in OSA [ 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…This was consistent with studies supporting OSA as the most prevalent secondary contributor to elevated blood pressure in patients with resistant hypertension [ 32 ]. Increased sympathetic activity, intrathoracic pressure during episodes of apnea resulting in hypertension, and excessive rates of venous return have been postulated as possible mechanisms for the development of AF in OSA [ 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…A recent study specifically states that the lectin-like oxidized lowdensity lipoprotein receptor-1 (LOX-1) and the potent vasoconstrictor endothelin-1 (ET-1) are intricately involved in atherosclerotic plaques formation and assisting in detecting the CV risk in OSA subjects, respectively [24]. Indeed, there is a growing body of research that links OSA to arrhythmias and sudden cardiac death [25]. Intriguingly, a bidirectional relationship interplays between chronic kidney disease and OSA; and vice versa, continuous, supplemental oxygen therapy with continuous, positive airway pressure improves the renal function in OSA patients [16].…”
Section: Discussionmentioning
confidence: 99%
“…These acute triggers can be explained by previously studied arrhythmogenic mechanisms, where an alteration in the intrathoracic pressure leads to a stretch in the muscle of the left atrium, which causes distention. This distention in turn gives rise to increased atrial premature beats and QT interval prolongation on an electrocardiogram (EKG) [ 70 ]. As a result, ventricular tachycardia and/or sudden cardiac death due to this acute episode can ensue.…”
Section: Complications Of Obstructive Sleep Apneamentioning
confidence: 99%
“…As a result, ventricular tachycardia and/or sudden cardiac death due to this acute episode can ensue. The triggered activity and automaticity due to enhanced sympathetic discharge, and parasympathetic surge on the other hand during apnea, can cause sinus nodal disease and atrial fibrillation ( Figure 3 ) [ 70 , 71 ]. It is important to note that while there is a strong association between OSA and CVD, many trials have failed to establish that these symptoms improve when treating for OSA.…”
Section: Complications Of Obstructive Sleep Apneamentioning
confidence: 99%
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