Obstructive congenital gingival granular cell tumour

Bilen, Bilge Türk; Alaybeyoğlu, Nezih; Arslan, Ahmet; Türkmen, Emine; Aslan, Serkan; Çelik, Mehmet

doi:10.1016/j.ijporl.2004.07.007

Cited by 33 publications

(18 citation statements)

References 16 publications

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“…Several theories have been suggested, including an undifferentiated mesenchymal cell origin, fibroblastic, and myoblastic, histiocytic, odontogenic, [4] neurogenic, endothelial and endocrinologic aetiologies [1,6,7,9,11]. Most of the reported cases support a mesenchymal origin, rather than odontogenic [5].…”

Section: Discussionmentioning

confidence: 99%

“…2. In contrast to the granular cell tumour, no layer of pseudoepitheliomatous hyperplasia of the overlying squamous mucosa is present [1,4,11,16]. Immunochemically, S100 protein antigen staining has showed negative in three of the cases (specific for Schwann cells), which excludes a neurogenic aetiology and thereby differentiates between an epulis and a granular cell tumour [4,7,11].…”

Section: Discussionmentioning

confidence: 99%

“…The congenital epulis is also negative for 75 kD nerve growth factor receptor, trk gene product and phosphotyrosine positive cells, all confirming a lack of neurogenic origin, in contrast to the granular cell tumour (Table 2). PAS, a marker of glycogen, is often positive in both [1,7].…”

Section: Discussionmentioning

confidence: 99%

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Congenital epulis of the jaw: a series of five cases and review of literature

et al. 2008

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This article describes five cases of congenital epulis, a rare and benign swelling in the mouth of a newborn, which is not widely known. We present five cases: four cases presented as single pedunculated nodules of the gingiva and in one case two nodules were present. Of all, 50% were located at the maxilla. Excision was performed in four of the five cases and in one case, spontaneous regression was awaited. No recurrence was reported. The characteristic features of congenital epulis are a pedunculated, flesh-pink coloured tumour with a predominant occurrence on the anterior maxillary alveolar ridge in a female newborn. Although the aetiology is unknown, most authors suggest a mesenchymal, rather than an odontogenic, origin. Endogenous hormonal factors might influence growth prenatally. Histological findings include granular cells with eosinophilic cytoplasm and small, eccentric nuclei. Despite the fact that the lesion can be a striking sight, spontaneous regression is possible and can be awaited. Indications for non-radical excision under local anaesthesia are severe upper airway obstruction and interference with feeding technique. In conclusion, we provide clinical and histological information about congenital epulis, so that this entity will be more easily recognised and relevant information given to parents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Congenital epulis of the jaw: a series of five cases and review of literature

et al. 2008

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“…These are the myoblastic, odontogenic, neurogenic, histiocytic and endocrinologic theories [2] [11]. CE which in general originates from the alveolar crest of the maxilla is reported three times more frequent in the maxillary alveolus than in the mandibular alveolus [12] [13]. Although the histology and the origin of CE are not known yet, the electron microscopic examination of CE shows evidence that it originates from gingival stromal cells [4].…”

Section: Discussionmentioning

confidence: 99%

Congenital Epulis of the Newborn: A Case Report

Pekçetin¹,

Senemtaşı²,

Koçak³

et al. 2018

OJST

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Background: Congenital epulis (CE) also known as congenital granuler cell tumor is a rarely encountered pathology the majority of which originates from the gingival mucosa, particularly the anterior portion of the maxillary alveolar ridge. CE mostly seen in girls. CE with unclear histogenesis and etiology is seen at birth as a solitary mass in oral cavity. Apart from non-congenital epulis, it contains granular cells. So lesion is named congenital granular cell tumor. CE has a benign histopathology and after surgery there is no recurrence reported in the literature. Aim: The purpose of this case report, is to present, 5 day-old female neonatal girl who was seen CE on the left maxillary alveolar ridge on the region of the future incisors. Case Presentation: The tumoral lesion was well-circumscribed and 10 mm in diameter, smooth surfaced and red in colour much like alveolar mucosal tissue. Tumoral lesion was affecting oral feeding due to obstruction. Excisional biopsy was performed under topical anesthesia. The histopathology was reported as congenital epulis. During the 4 months follow-up, we have seen no complication. Conclusion: CE is a neonatal congenital tumor which is very rare. The treatment of CE is surgical excision. Unless the early treatment is not executed, tumor may cause difficulties in oral feeding and respiration. Therefore it should be excised in an early period.

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“…It has been described in the literature worldwide [2]. Etiology is still unclear [9]. Because spontaneous regression of the lesion is rare [10,11], surgical excision is the only valuable therapeutic option.…”

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confidence: 99%