Prenatal diagnosis and multidisciplinary approach to the congenital gingival granular cell tumor

Messina, Mario; Severi, Filiberto Maria; Buonocore, G; Molinaro, Francesco; Amato, G

doi:10.1016/j.jpedsurg.2006.07.003

Cited by 30 publications

(21 citation statements)

References 14 publications

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“…The main differential diagnosis includes Epstein pearls, granular cell tumour, vascular malformations and neuroectodermal tumours of infancy [5,8,10,11].…”

Section: Discussionmentioning

confidence: 99%

“…MRI can be used to determine the depth and localisation of a large lesion, for prenatal planning of delivery method and intervention. This might facilitate parental acceptance and a better mother-infant relationship, since they can prepare for the sight of the lesion and the eventual interventions after birth [10,15]. Treatment consists of simple conservative excision under general or local anaesthesia, [2] only when major feeding or obstructive respiratory problems are present or a pathological confirmation is looked for [7].…”

Section: Discussionmentioning

confidence: 99%

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Congenital epulis of the jaw: a series of five cases and review of literature

et al. 2008

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This article describes five cases of congenital epulis, a rare and benign swelling in the mouth of a newborn, which is not widely known. We present five cases: four cases presented as single pedunculated nodules of the gingiva and in one case two nodules were present. Of all, 50% were located at the maxilla. Excision was performed in four of the five cases and in one case, spontaneous regression was awaited. No recurrence was reported. The characteristic features of congenital epulis are a pedunculated, flesh-pink coloured tumour with a predominant occurrence on the anterior maxillary alveolar ridge in a female newborn. Although the aetiology is unknown, most authors suggest a mesenchymal, rather than an odontogenic, origin. Endogenous hormonal factors might influence growth prenatally. Histological findings include granular cells with eosinophilic cytoplasm and small, eccentric nuclei. Despite the fact that the lesion can be a striking sight, spontaneous regression is possible and can be awaited. Indications for non-radical excision under local anaesthesia are severe upper airway obstruction and interference with feeding technique. In conclusion, we provide clinical and histological information about congenital epulis, so that this entity will be more easily recognised and relevant information given to parents.

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“…The main differential diagnosis includes Epstein pearls, granular cell tumour, vascular malformations and neuroectodermal tumours of infancy [5,8,10,11].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Congenital epulis of the jaw: a series of five cases and review of literature

et al. 2008

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“…In general, these lesions do not progress after birth; however, spontaneous regressions are rare. Surgical excision affords a cure and no cases of relapse or malignant transformation have been reported, even after incomplete resection [7].…”

Section: Discussionmentioning

confidence: 99%

Childhood granular cell tumors: Two case reports

Leboulanger

Rouillon

Papon

et al. 2008

International Journal of Pediatric Otorhinolaryngology

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“…Spontaneous regression of the lesion is rare. 13 A larger lesion may interfere with eating or drinking, requiring conservative excision as soon as the child is large enough to safely undergo surgery. 14 There is no tendency for recurrence and malignant transformation has not been reported.…”

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confidence: 99%

“…14 There is no tendency for recurrence and malignant transformation has not been reported. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] …”

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confidence: 99%

Congenital Epulis in the Newborn, Review of the Literature and a Case Report

Eghbalian

Monsef

2009

Journal of Pediatric Hematology/Oncology

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Congenital epulis (CE) is a rare tumor of the newborn, also known as granular cell tumor or congenital gingival granular cell tumor because of its histologic features. Neumann first described CE in 1871. Epulis is seen only in the newborn and is a different entity from other granular cell tumors. CE has a female predilection with 8:1 ratio. Epulis is most frequently located on the anterior maxillary alveolar ridge and usually occurs as a single mass although 10% cases occur as multiple. CE clinically appears as a pedunculated protuberant mass, which may interfere with respiration or feeding. In cases with large lesions mechanical oral and nasal obstruction can impair fetal deglutition and neonatal respiratory efforts resulting in polyhydramnios prenatally or respiratory impairment postnatally. The exact histiogenesis is still uncertain. The recommended treatment is prompt surgical resection. Recurrences of the tumor and damage to future dentition have not been reported. Spontaneous regression of congenital epulis has been reported in a few cases. However, surgical excision is generally indicated due to interference with feeding or respiration. We report a female neonate with congenital multiple tumors in the anterior maxillary alveolar ridge and review the relevant literature. The tumors were resected by surgical excision. The intraoperative and postoperative course was uneventful. Follow-up for 6 months did not show recurrence.

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Prenatal diagnosis and multidisciplinary approach to the congenital gingival granular cell tumor

Cited by 30 publications

References 14 publications

Congenital epulis of the jaw: a series of five cases and review of literature

Congenital epulis of the jaw: a series of five cases and review of literature

Childhood granular cell tumors: Two case reports

Congenital Epulis in the Newborn, Review of the Literature and a Case Report

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