Obstruction of Bowel due to Lesion in the Myenteric Plexus

Dyer, N. H.; Dawson, A. M.; Smith, Barbara; Todd, Ian P.

doi:10.1136/bmj.1.5645.686

Cited by 93 publications

(23 citation statements)

References 10 publications

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“…In the early clinical and radiologic descriptions of chronic idiopathic intestinal pseudoobstruction, no specific histopathologic abnormality was defined [2,7]. More recent reports have described several different myentenc plexus abnormalities in some patients [9,10] and smooth muscle abnormalities in others [1,11,12] …”

Section: Roentgen Ray Societymentioning

confidence: 99%

Radiologic and histologic differentiation of neuromuscular disorders of the gastrointestinal tract: visceral myopathies, visceral neuropathies, and progressive systemic sclerosis

Rohrmann

Ricci

Krishnamurthy

et al. 1984

American Journal of Roentgenology

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Section: Roentgen Ray Societymentioning

confidence: 99%

Radiologic and histologic differentiation of neuromuscular disorders of the gastrointestinal tract: visceral myopathies, visceral neuropathies, and progressive systemic sclerosis

Rohrmann

Ricci

Krishnamurthy

et al. 1984

American Journal of Roentgenology

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“…Enteric gliosis has been observed in the hypertrophic gut induced by experimental intestinal stenosis (Gabella, 1984). Additionally, some patients with neuropathic intestinal pseudo-obstruction exhibit enteric gliosis in addition to degeneration of myenteric neurons (Kirshnamurthy and Schuffler, 1987;Smith, 1968;Dyer et al, 1969). The prominent survival effect of the FGFs on enteric glia suggests that these growth factors could contribute to enteric gliosis in vivo, as they do to astrogliosis in CNS (Barotte et al, 1989).…”

Section: Discussionmentioning

confidence: 95%

Electrophysiologic and molecular properties of cultured enteric glia

Broussard¹,

Bannerman²,

Tang³

et al. 1993

J of Neuroscience Research

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Enteric glia, the support cells of myenteric ganglia, have been widely studied with respect to their morphology and immunohistochemical phenotype, but little is known about their functional properties. We developed a method for the amplification of enteric glia from newborn guinea pigs to further characterize these cells. Treatment with a combination of basic fibroblast growth factor and the adenylate cyclase activator, cholera toxin, permitted expansion of enteric glial cultures to confluence and serial passage for up to 8 months. The long-term cultured cells retained expression of 1) S100 protein, 2) GD3 ganglioside recognized by the monoclonal antibody LB1, and 3) the gene encoding glutamine synthetase. The electrophysiologic properties of cultured enteric glia were studied under whole-cell patch clamp conditions. Most cells expressed "delayed rectifier"-type potassium currents, and some also demonstrated tetrodotoxin-sensitive sodium currents. Other subsets of voltage-dependent potassium currents, calcium currents, and glutamate-gated currents were not demonstrable.

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“…Ganglion cells are invariably present in the involved and uninvolved portions of the intestine. These are normal in number and appearance by light microscopy, but some investigators [11] have been able to demonstrate degenerative changes of the myenteric plexus by using special histologic techniques. Hypertrophy of the inner muscular layer of the bowel wall was found in the first reported cases [1,6].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic intestinal pseudo-obstruction in a family

Teixidor

Heneghan

1978

Gastrointest Radiol

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A patient with severe manifestations of idiopathic intestinal pseudo-obstruction is presented. Three members of his family suffer from similar symptoms but in a much milder form. The disease has a wide range of clinical and radiologic presentations and its diagnosis is dependent upon the exclusion of all known causes of intestinal pseudo-obstruction. A high incidence of associated megacystis in this family as well as in some reported cases in the literature lead us to conclude that idiopathic intestinal pseudo-obstruction is not a primary disease of the gastrointestinal tract. Its etiology remains obscure.

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Obstruction of Bowel due to Lesion in the Myenteric Plexus

Cited by 93 publications

References 10 publications

Radiologic and histologic differentiation of neuromuscular disorders of the gastrointestinal tract: visceral myopathies, visceral neuropathies, and progressive systemic sclerosis

Radiologic and histologic differentiation of neuromuscular disorders of the gastrointestinal tract: visceral myopathies, visceral neuropathies, and progressive systemic sclerosis

Electrophysiologic and molecular properties of cultured enteric glia

Idiopathic intestinal pseudo-obstruction in a family

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