Obstetric complications in diabetic pregnancy

Lunell, Nils‐Olov

doi:10.1530/acta.0.111s0117

Cited by 3 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In uteroplacental insufficiency fetal nutrition and oxygenation are impaired, leading to growth retardation and acidaemia with hypoxaemia which are accompanied by reduced fetal breathing and urine production (Ribbert et al 1990). In contrast, in diabetic pregnancies fetal acidaemia is associated with maternal hyperglycaemia, and both the amniotic fluid volume and fetal breathing movements are either normal or increased (Roberts et al 1980; Lunell 1986). In this respect, normal fetal breathing and amniotic fluid volume may provide false reassurance of fetal wellbeing, not only in uncomplicated diabetic pregnancies at term but also in diabetic pregnancies with the added complication of placental insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Prediction of fetal acidaemia in pregnancies complicated by maternal diabetes mellitus by biophysical profile scoring and fetal heart rate monitoring

Salvesen¹,

Freeman²,

Brudenell³

et al. 1993

BJOG

View full text Add to dashboard Cite

Objective To determine whether computer assisted fetal heart rate analysis or the biophysical profile score can provide noninvasive prediction of fetal acidaemia. Design Cross sectional study. Setting Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London. Subjects Forty‐one women with pregnancies complicated by diabetes mellitus. Interventions Fetal heart rate (FHR) monitoring with computer assisted analysis, biophysical profile score (BPS) and cordocentesis for measurement of umbilical venous blood glucose concentration and blood gases, up to 24 h before delivery at 27 to 39 weeks gestation. Results The mean umbilical venous blood pH was significantly lower than the normal mean for gestation, and was below the 5th centile in 18 pregnancies, including all six cases where the mother had nephropathy and hypertension. The mean pO2 was not significantly different from the normal mean for gestation. There were significant associations between fetal acidaemia and both the BPS (r= 0.46, P<0.01) and FHR variation (r= 0.42, P<0.01). However, of the 12 acidaemic fetuses of non‐nephropathic mothers, nine had normal BPS and six had normal FHR variation. Conclusions In pregnancies complicated by maternal diabetes mellitus, BPS and FHR variation are of limited value in the prediction of fetal blood pH.

show abstract

Section: Discussionmentioning

confidence: 99%

Prediction of fetal acidaemia in pregnancies complicated by maternal diabetes mellitus by biophysical profile scoring and fetal heart rate monitoring

Salvesen¹,

Freeman²,

Brudenell³

et al. 1993

BJOG

View full text Add to dashboard Cite

show abstract

“…This association may explain the slightly high odds ratio for all CHD. Because preeclampsia is a common obstetric complication in diabetic pregnancies (17), the possible effect of toxicosis was studied after exclusion of triplets with maternal diabetes. The association remained, however.…”

Section: Discussionmentioning

confidence: 99%

“…Hydramnios is often associated with diabetic pregnancies (11,17). Because of the well-known association between anencephaly or esophagus atresia and hydramnios, all cases with an associated extracardiac malformation were excluded.…”

Section: Discussionmentioning

confidence: 99%

A case-control study of major congenital heart defects in Sweden ? 1981?1986

Pradat

1992

Eur J Epidemiol

View full text Add to dashboard Cite

This paper reports the results of a case-control study of major congenital heart defects (CHD) in Sweden. During the period 1981-1986, 1,324 such cases were identified and 2,648 controls were selected. Some common maternal characteristics and exposures were studied using information from prospectively collected data. Possible associations with CHD were found for previous perinatal death, maternal diabetes, epilepsy, hydramnios and disproportion between fetus and pelvis. More specific associations were observed between previous spontaneous abortion, epilepsy, hydramnios and truncus anomalies and between diabetes and septal anomalies. However, no associations were found with involuntary childlessness, contraceptive use, or smoking.

show abstract

Chromosomal Anomalies among the Offspring of Women with Gestational Diabetes

Moore¹,

Bradlee²,

Singer³

et al. 2002

American Journal of Epidemiology

View full text Add to dashboard Cite

A limited body of data over the past 35 years has suggested that autoimmunity may be responsible for some cases of aneuploidy. The role of diabetes mellitus in the etiology of chromosomal anomalies has been infrequently studied. This study was designed to compare the prevalence of chromosome abnormalities among the offspring of women with gestational diabetes and the offspring of women without it. The authors used data from 7,332 women who underwent amniocentesis in a prospective study of pregnancy outcome (1984-1988) and examined the prevalence of autosomal and sex chromosome defects associated with gestational diabetes. Among the offspring of 231 women with gestational diabetes, the crude prevalence of chromosomal defects was twice as high as that seen in the offspring of 7,101 women without gestational diabetes. These anomalies were predominantly numeric sex chromosome defects. After adjusting for potential confounding by maternal age, body mass index, education, and first-trimester exposures in multiple logistic regression analysis, the authors found that women with gestational diabetes were 7.7 times as likely (95% confidence interval: 2.8, 21.1) to have an infant with a numeric sex chromosome defect as those without gestational diabetes. These results support the theory that some women who develop gestational diabetes may have underlying biochemical changes that induce nondisjunction and the development of chromosomal defects.

show abstract

Obstetric complications in diabetic pregnancy

Abstract: Some of the most common complications in

Cited by 3 publications

References 12 publications

Prediction of fetal acidaemia in pregnancies complicated by maternal diabetes mellitus by biophysical profile scoring and fetal heart rate monitoring

Prediction of fetal acidaemia in pregnancies complicated by maternal diabetes mellitus by biophysical profile scoring and fetal heart rate monitoring

A case-control study of major congenital heart defects in Sweden ? 1981?1986

Chromosomal Anomalies among the Offspring of Women with Gestational Diabetes

Contact Info

Product

Resources

About