A case-control study of major congenital heart defects in Sweden ? 1981?1986

Pradat, Pierre

doi:10.1007/bf00145321

Cited by 28 publications

(14 citation statements)

References 35 publications

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“…Some recent epidemiological studies have clarified that maternal lifestyles, such as smoking or drinking habits and passive smoking during pregnancy, provoke some congenital anomalies (Jones and Smith, 1973;Himmelberger et al, 1978;Ericson et al, 1979;Kuroki, 1988;Jacobson et al, 1993;Yuan et al, 1994), although there are negative reports (Borlee et al, 1978;Marbury et al, 1983;Pradat, 1992). However, to our knowledge, an association of anal atresia with smoking and/or drinking during pregnancy has not been previously reported.…”

Section: Discussionmentioning

confidence: 83%

Anal atresia: Effect of smoking and drinking habits during pregnancy

1995

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SummaryUsing data compiled from 216,707 births from the population-based Kanagawa Birth Defects Monitoring Program (KAMP), we conducted a case-control study to evaluate the effect of maternal smoking and/or drinking during pregnancy on the risk of infants' anal atresia in 1989-1994. The frequency of maternal smoking (including passive smoking) and/or maternal drinking during pregnancy among 84 infants with anal atresia was compared with 174 matched controls. The 84 anal atresias include 49 cases of isolated anal atresia and 35 cases of syndromal anal atresia. Our findings suggest that maternal drinking during early pregnancy is associated with an increased risk of isolated anal atresia (OR=4.8, 95~ CI 1.2 to 19.1, p<0.05). A slightly increased trend was also observed in the association of maternal smoking during pregnancy with both in the pooled groups of anal atresia (OR= 1.4, 95 ~ CI 0.5 to 3.6).

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Section: Discussionmentioning

confidence: 83%

Anal atresia: Effect of smoking and drinking habits during pregnancy

1995

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“…82 Because several therapy-related factors could account for this increased risk, including direct teratogenic effects of anticonvulsant drug therapy and an indirect effect of the drugs by interfering with folate metabolism, it has been difficult to determine whether maternal seizures are independently associated with an increased risk of heart defects.…”

Section: Epilepsymentioning

confidence: 99%

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Jenkins¹,

Correa²,

Feinstein³

et al. 2007

Circulation

700

336

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Abstract-Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although relatively less information has been available on noninherited modifiable factors that may have an adverse effect on the fetal heart, there is a growing body of epidemiological literature on this topic. This statement summarizes the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects. Information is summarized for periconceptional multivitamin or folic acid intake, which may reduce the risk of cardiac disease in the fetus, and for additional types of potential exposures that may increase the risk, including maternal illnesses, maternal therapeutic and nontherapeutic drug exposures, environmental exposures, and paternal exposures. Information is highlighted regarding definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis. Caveats regarding interpretation of possible exposure-outcome relationships from case-control studies are given because this type of study has provided most of the available information. Guidelines for prospective parents that could reduce the likelihood that their child will have a major cardiac malformation are given. Issues related to pregnancy monitoring are discussed. Knowledge gaps and future sources of new information on risk factors are described.

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“…Epilepsy and anticonvulsant medications also have been studied as possible risk factors for CVM. Several epidemiological studies identi®ed associations between CVM and epilepsy [Dansky and Finnell, 1991;Pradat, 1992], but an unresolved question is whether the underlying risk factor is some aspect of the disease itself or of speci®c anticonvulsant medications, many of which are strongly implicated as teratogens [Hanson et al, 1976;Bossi, 1983;Zierler and Rothman, 1985;Bracken, 1986]. No speci®c pattern of heart defects seems to be closely related to these factors, with reported associations involving CVM as a whole as well as the common arterial trunk, transposed great arteries, and septal defects.…”

Section: Maternal Risk Factorsmentioning

confidence: 99%

Epidemiology of cardiovascular malformations: Prevalence and risk factors

Loffredo

2000

Am. J. Med. Genet.

162

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Epidemiological approaches to the study of cardiovascular malformations (CVMs) face challenges of disease definition, nomenclature, changing diagnostic methodologies, the rarity of the disease in the general population, and the incorporation of current knowledge on genetics and morphogenesis into designing studies to investigate risk factors and implement preventive strategies. Previous studies, especially the population-based Baltimore-Washington Infant Study, have documented variability in the prevalence of specific types of CVM by time, place, and personal characteristics and have highlighted the potential prevention of diabetes-associated heart malformations through timely medical management of pre-conception diabetes. Left-sided obstructive heart defects have been identified as targets for new studies of genetic risk factors. Potential environmental risk factors for CVMs also have been identified, such as organic solvents and pesticides, coincident with the emergence of new strategies to study genetic susceptibility and gene-environment interactions. Increased collaborative, multicenter research on these and other factors, such as nutritional factors in early pregnancy, offers new hope for potentially reducing the burden of CVM in the population.

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A case-control study of major congenital heart defects in Sweden ? 1981?1986

Cited by 28 publications

References 35 publications

Anal atresia: Effect of smoking and drinking habits during pregnancy

Anal atresia: Effect of smoking and drinking habits during pregnancy

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Epidemiology of cardiovascular malformations: Prevalence and risk factors

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