Obstetric and perinatal outcomes of in vitro fertilization and natural pregnancies in the same mother

Herman, Hadas Ganer; Mizrachi, Yossi; Alon, Ayala Shevach; Farhadian, Yasmin; Gluck, Ohad; Bar, Jacob; Kovo, Michal; Raziel, Arieh

doi:10.1016/j.fertnstert.2020.10.060

Cited by 10 publications

(2 citation statements)

References 20 publications

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“…Whether the additional maternal and neonatal risks are due to the technology itself or underlying infertility-linked factors remains unresolved ( Hoyos and Ory, 2021 ). When the obstetric and perinatal outcomes of ART and spontaneously conceived (SC) pregnancies were compared using the same mother as control, the results were similar ( Ganer Herman et al, 2021 ), suggesting that health outcomes may be predominantly linked to the parents and not necessarily to ART ( Hwang et al, 2018 ; Molinaro, 2021 ).…”

Section: Introductionmentioning

confidence: 95%

The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution

Schroêder

Badini

Sferruzzi‐Perri

et al. 2022

Front. Cell Dev. Biol.

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The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978. ART use is currently on the rise, given growing infertility and the increase in conception age among men and women in industrialized countries. Though obstetric and perinatal outcomes have improved over the years, pregnancies achieved by ART still bear increased risks for the mother and the unborn child. Moreover, given that the first generation of ART offspring is now only reaching their forties, the long-term effects of ART are currently unknown. This is important, as there is a wealth of data showing that life-long health can be predetermined by poor conditions during intrauterine development, including irregularities in the structure and functioning of the placenta. In the current review, we aim to summarize the latest available findings examining the effects of ART on the cardiometabolic, cognitive/neurodevelopmental, and behavioral outcomes in the perinatal period, childhood and adolescence/adulthood; and to examine placental intrinsic factors that may contribute to the developmental outcomes of ART offspring. Altogether, the latest knowledge about life outcomes beyond adolescence for those conceived by ART appears to suggest a better long-term outcome than previously predicted. There are also changes in placenta structure and functional capacity with ART. However, more work in this area is critically required, since the potential consequences of ART may still emerge as the offspring gets older. In addition, knowledge of the placenta may help to foresee and mitigate any adverse outcomes in the offspring.

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Section: Introductionmentioning

confidence: 95%

The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution

Schroêder

Badini

Sferruzzi‐Perri

et al. 2022

Front. Cell Dev. Biol.

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“…PE not only increases the risk of preterm birth and low birth weight babies, but is also a principal cause of maternal and fetal mortality [2]. Moreover, PE has long-term postpartum effects on the mother and the offspring later in life, such as increased risk of cardiovascular disease and hypertension [3]. Every year, 2-8% of all pregnant women suffer from PE globally [4].…”

Section: Introductionmentioning

confidence: 99%

Exosomal miR-486-5p derived from human placental microvascular endothelial cells regulates proliferation and invasion of trophoblasts via targeting IGF1

Zhou

Shi

et al. 2021

Human Cell

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Preeclampsia (PE) is a serious complication of pregnancy. Exosomes are known to be upregulated in PE. In this study, we sought to investigate the effect of miR-486-5p from human placental microvascular endothelial cells, on the function of trophoblast cells. To investigate the function of human placental microvascular endothelial cell (HPVEC)-derived exosomes on trophoblast cells, HPVECs were treated with hypoxia/reoxygenation (H/R). The separation efficiency of exosomes was determined by transmission electron microscopy, nanosight and Western blot. Cell Counting Kit-8, EdU staining, wound-healing, and transwell assay were performed to detect the effect of exosomally transferred miR-486-5p inhibitor on proliferation, migration and invasion of trophoblast cells. MiRDB and dual-luciferase report assay were used to find the target of miR-486-5p. Our data revealed that miR-486-5p was significantly upregulated in H/R-treated HPVEC-Exo, and miR-486-5p was enriched in HPVEC-Exo. miR-486-5p inhibitor carried by HPVEC-Exo significantly inhibited the proliferation, migration and invasion of trophoblast cells. Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function. In summary, H/R-treated HPVEC-derived exosomally expressing miR-486-5p inhibitor significantly inhibited the proliferation, migration and invasion of trophoblast cells via downregulation of IGF1. The findings from the present study may be useful in the development of treatments for PE.

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Increased Risk of Preeclampsia with Assisted Reproductive Technologies

2023

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Obstetric and perinatal outcomes of in vitro fertilization and natural pregnancies in the same mother

Cited by 10 publications

References 20 publications

The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution

The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution

Exosomal miR-486-5p derived from human placental microvascular endothelial cells regulates proliferation and invasion of trophoblasts via targeting IGF1

Increased Risk of Preeclampsia with Assisted Reproductive Technologies

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