Obstetric and newborn infant outcomes in human immunodeficiency virus–infected women who receive highly active antiretroviral therapy

Haeri, Sina; Shauer, Marla; Dale, Monica; Leslie, Jennie; Baker, Arthur M.; Saddlemire, Stephanie; Boggess, Kim

doi:10.1016/j.ajog.2009.06.017

Cited by 53 publications

(52 citation statements)

References 15 publications

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“…Additional measures including selective caesarean or avoidance of breastfeeding are strongly recommended. However, adverse pregnancy outcome have been increasingly reported by several observational studies in HIV‐infected women exposed to HAART 6, 7, 8, 9, 10, 11. Anti‐retrovirals and HIV‐infection have been associated with pre‐eclampsia, stillbirth, pre‐term labour, low birth weight and intrauterine growth restriction (IUGR) 12, 13, 14, 15, 16, 17.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial toxicity and caspase activation in HIV pregnant women

Hernández

Morén

Catalán-García

et al. 2016

J Cellular Molecular Medi

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To assess the impact of HIV‐infection and highly active anti‐retroviral treatment in mitochondria and apoptotic activation of caspases during pregnancy and their association with adverse perinatal outcome. Changes of mitochondrial parameters and apoptotic caspase activation in maternal peripheral blood mononuclear cells were compared at first trimester of pregnancy and delivery in 27 HIV‐infected and ‐treated pregnant women versus 24 uninfected pregnant controls. We correlated immunovirological, therapeutic and perinatal outcome with experimental findings: mitochondrial DNA (mtDNA) content, mitochondrial protein synthesis, mitochondrial function and apoptotic caspase activation. The HIV pregnancies showed increased adverse perinatal outcome (OR: 4.81 [1.14–20.16]; P < 0.05) and decreased mtDNA content (42.66 ± 5.94%, P < 0.01) compared to controls, even higher in naïve participants. This depletion caused a correlated decrease in mitochondrial protein synthesis (12.82 ± 5.73%, P < 0.01) and function (20.50 ± 10.14%, P < 0.001), not observed in controls. Along pregnancy, apoptotic caspase‐3 activation increased 63.64 ± 45.45% in controls (P < 0.001) and 100.00 ± 47.37% in HIV‐pregnancies (P < 0.001), in correlation with longer exposure to nucleoside analogues. HIV‐infected women showed increased obstetric problems and declined genetic and functional mitochondrial parameters during pregnancy, especially those firstly exposed to anti‐retrovirals. The apoptotic activation of caspases along pregnancy is emphasized in HIV pregnancies promoted by nucleoside analogues. However, we could not demonstrate direct mitochondrial or apoptotic implication in adverse obstetric outcome probably because of the reduced sample size.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial toxicity and caspase activation in HIV pregnant women

Hernández

Morén

Catalán-García

et al. 2016

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…While there is an increasing number of studies that suggest higher risk of preterm birth (PB) (< 37 weeks) [1][2][3][4][5][6][7] and low birth weight (LBW) 2,[8][9][10] among babies of women receiving HAART during pregnancy, there are also some studies that did not observe this association. [11][12][13][14][15][16] Most of the studies are from developed regions 4,[17][18][19] and only recently research findings are emerging from developing regions. 7,[20][21][22] Previous research from developed regions assessed the role of HAART containing protease inhibitors (PI), whereas the recent studies from developing regions have also evaluated the effect of PI excluded HAART on pregnancy outcomes (Table 1).…”

mentioning

confidence: 99%

Effect of Highly Active Antiretroviral Treatment (HAART) During Pregnancy on Pregnancy Outcomes: Experiences from a PMTCT Program in Western India

Darak

Darak²,

Kulkarni³

et al. 2013

AIDS Patient Care and STDs

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“…Contradictory data about the association between HIV infection, ART and pre-eclampsia have been reported [90][91][92][93][94][95], and maybe related to differences in the study populations and their underlying medical morbidities. A recent report on a cohort of HIV-infected pregnant women from Latin America and Caribbean countries suggested that a previous history of preeclampsia/eclampsia, a gestational age-adjusted body mass index ‡ 25 kg/m, hemoglobin at delivery ‡ 11 g/dl and use of HAART before conception puts women at an increased risk of developing PE/E during pregnancy [96].…”

Section: Protease Inhibitormentioning

confidence: 99%