Obsessive–compulsive symptoms and overall psychopathology in psychotic disorders: longitudinal assessment of patients and siblings

Schirmbeck, Frederike; Swets, Marije; Meijer, Carin J.; Zink, Mathias; Haan, Lieuwe de

doi:10.1007/s00406-016-0751-0

Cited by 19 publications

(26 citation statements)

References 55 publications

(66 reference statements)

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“…The longitudinal results partly stand in line with results of previous analyses from the GROUP data, comparing OCS status groups and the course of PANSS and GAF scores [ 38 ] as well as cognitive functioning over the 3 year assessment period [ 37 ]. In all three studies at baseline, the group which was going to develop OCS at follow-up—the OCS de novo group—already showed more impairment than the no-OCS group.…”

Section: Discussionsupporting

confidence: 86%

“…To study the course of OCS and its relationship with the course of motor symptoms both OCS and motor symptoms were categorized into four groups as was done in our previous analyses [ 37 , 38 ]: (1) a no symptom group, (2) a remission group, showing symptoms at baseline assessment only, (3) a de novo group, showing symptoms at follow-up, but not at baseline and (4) a persistent group, showing symptoms at both assessments. Subsequently, the relationship between those groups and motor symptoms was analyzed (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Longitudinal association between motor and obsessive compulsive symptoms in patients with psychosis and their unaffected siblings

Swets

Schirmbeck²,

Dekker

et al. 2018

Eur Arch Psychiatry Clin Neurosci

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Little is known about the co-prevalence of obsessive compulsive symptoms (OCS) and motor symptoms in patients with psychotic disorders. Cross-sectional associations between OCS and motor symptoms were assessed at baseline and at 3 years follow-up in patients (n = 726) with psychotic disorders and in their unaffected siblings (n = 761) from the Dutch Genetic Risk and Outcome of Psychosis (GROUP) study. Furthermore, longitudinal associations between changes in OCS and motor symptoms were evaluated. At baseline, OCS was not associated with any motor symptom (akathisia, dyskinesia, parkinsonism or dystonia) in patients. At follow-up, patients with OCS reported significantly more akathisia. Dividing the patients into four groups-no OCS, OCS remission with OCS only at baseline, OCS de novo with OCS only at follow-up and a persistent OCS group-revealed that the OCS de novo group already reported more akathisia at baseline compared to the no-OCS group. At follow-up, both the OCS de novo and the persistent OCS group reported more akathisia. These results remained significant after correcting for relevant confounders clozapine, GAF score, PANSS-negative score and IQ. Motor symptoms at baseline were significantly associated with OCS at follow-up, but not the other way around. In siblings, OCS at baseline was associated with akathisia, but this association was lost at follow-up. Results suggest that motor symptoms might precede co-occurring OCS in patients with psychotic disorders. However, no inference can be made about causality, and further prospective research is needed to investigate this assumption.

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Section: Discussionsupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Longitudinal association between motor and obsessive compulsive symptoms in patients with psychosis and their unaffected siblings

Swets

Schirmbeck²,

Dekker

et al. 2018

Eur Arch Psychiatry Clin Neurosci

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“…Negative childhood events (and especially serious parental disease or disability and conflicts within the childhood family) were related to obsessive-compulsive symptoms in males. In a Dutch study, psychosis patients with co-occurring obsessive-compulsive symptoms presented a more severe clinical picture and the authors discussed that the possible mechanisms could be increased sensitivity to stress, negative affectivity, and dysfunctional coping (Schirmbeck et al, 2016). An association between obsessive-compulsive disorder and psychosis has been established, indicating a shared etiological pathway (Cederlöf et al, 2015;Meier et al, 2014).…”

Section: Adversities and Symptomatologymentioning

confidence: 99%

Childhood adversities and clinical symptomatology in first-episode psychosis

Lindgren

Mäntylä

Rikandi

et al. 2017

Psychiatry Research

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In addition to severe traumatic experiences, milder, more common childhood adversities reflecting psychosocial burden may also be common in people with psychotic disorders and have an effect on symptomatology and functioning. We explored eleven negative childhood experiences and their influence on clinical symptoms among young adults with first-episode psychosis (FEP, n = 75) and matched population controls (n = 51). Individuals with FEP reported more adversities than controls. Specifically serious conflicts within the family, bullying at school, maternal mental health problems, and one's own and parents' serious illness during childhood were experienced by the patients more often than by controls. In the FEP group, the severity of adversity was associated with increased anxiety, manic, and obsessive-compulsive symptoms, but not with the severity of positive psychotic symptoms. Adversity produced a more pronounced effect on symptoms in male patients than in female patients. To conclude, in line with earlier studies of more chronic psychosis, a majority of the participants with FEP reported exposure to childhood adversities, with the FEP group reporting more adversities than controls. High levels of mood and anxiety symptoms in patients with FEP may be related to cumulative exposure to childhood adversities. This should be taken into account in the treatment for FEP.

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“…Results indicate that patients with comorbid obsessive-compulsive symptoms suffer from more severe psychotic and affective symptomatology, which, in turn, leads to lower functioning and higher psychopathological burden. Furthermore, the authors found an association of symptom remission, suggesting that OCS, psychotic and affective symptoms functionally effect each other [5]. These two studies thus emphasize the importance of considering and integrating comorbidities in psychiatric research and, ultimately, clinical practice.…”

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confidence: 77%