Obsessive-Compulsive Disorder

The rational-choice theory of neurosis: Unawareness and an integrative therapeutic approach.

“…A variety of studies have shown that the same drug may be effective for disorders of different symptomology. For example, clomipramine, fluoxetine, fluvoxamine, monoamine oxidase inhibitors, and tricyclic antidepressants are effective in the treatment of both OCD (e.g., Abramowitz, 1997; Demal, Zitterl, Lenz, Zapotoczky, & Zitterl-Eglseer, 1996; Park, Jefferson, & Greist, 1997; Piccinelli, Pini, Bellantuono, & Wilkinson, 1995; Van Balkom et al, 1994) and agoraphobia and panic disorders (e.g., Alexander, 1991; Black, Wesner, Bowers, & Gabel, 1993; Burrows, Judd, & Norman, 1993; Gelder, 1992; Klerman, 1992; Westenberg, 1996). Similar results were reported for eating disorders (e.g., Hoffman & Halmi, 1993; Wolfe, 1995).…”

Practitioner Review: Treatment of Obsessive‐Compulsive Disorder in Children and Adolescents

“…) The choice of first-line treatment will depend on the symptom pattern and severity, as well as the patient and family's preference. Whatever is tried, it is important to urge flexibility, as a combination of drug and behavioral treatment may be needed (Greist, 1996 ;O'Connor, Todorov, Robillard, Borgeat, & Brault, 1999 ;Park, Jefferson, & Greist, 1997 ;Wever & Rey, 1997).…”

“…Clonazepam is a benzodiazepine with anxiolytic properties and serotonergic effects (Park et al, 1997 ;see March & Leonard, 1998). SRI augmentation in childhood-onset OCD has been described for a patient with onset of OCD symptoms at age 7 years but, other than psychotherapy, had no treatment for OCD until age 14 (Leonard et al, 1994).…”

Combination of clomipramine and nortriptyline in the treatment of obsessive-compulsive disorder: a double-blind, placebo-controlled trial

“…Obsessions, compulsions and rituals have been recognized as abnormal cognitions and behaviour for several centuries. These symptoms and signs, which have been variously referred to in different cultures and ages, are encompassed under the present diagnosis of obsessive‐compulsive disorder (OCD) ( 1, 2). Obsessions are intrusive, recurrent, unwanted ideas, thoughts or impulses that are difficult to dismiss despite their disturbing nature.…”

“…Although we can effectively treat many patients with OCD by combinations of medication and behaviour therapy, OCD patients tend to respond to medication with only a 30–60% reduction in symptoms, and patients tend to remain chronically symptomatic to some degree despite the best pharmacological interventions ( 3). Although some patients respond to a variety of drugs, the mainstay of pharmacological treatment for OCD is antidepressant drugs, especially those with prominent serotonergic reuptake blocking properties ( 2). Moreover, many studies using direct serotonergic agonists, such as m‐chlorophenylpiperazine, and serotonergic antagonists, such as metergoline, suggest that brain serotonergic systems maybe intimately involved in the pathogenesis of OCD ( 4, 5).…”