Obsessive and compulsive symptoms in chronic schizophrenia

Berman, Ileana; Kalinowski, Anthony G.; Berman, Stuart M.; Lengua, JoAnn; Green, Alan I.

doi:10.1016/0010-440x(95)90092-a

Cited by 188 publications

(128 citation statements)

References 14 publications

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“…The prevalence of OCD in the general population remains quite controversial ; however, it is certainly much lower (with estimates from 0.08 to 2.5 % ; e.g. Fireman et al 2001 ;Crino et al 2005) than the prevalence of OCD in schizophrenia, which has estimates ranging from 0.5 to 59.2 % both in firstepisode and in chronic schizophrenia (Bland et al 1987 ;Karno et al 1988 ;Berman et al 1995 ;Eisen et al 1997 ;Poyurovsky et al 1999aPoyurovsky et al , 2000Poyurovsky et al , 2003Poyurovsky et al , 2006Bermanzohn et al 2000 ;Kruger et al 2000 ;Niehaus et al 2005 ;Mukhopadhaya et al 2009) and for OCS in schizophrenia the estimated prevalence is similarly between 3.5 and 46 % (Rosen, 1957 ;Myers et al 1984 ;Fenton & McGlashan, 1986 ;Berman et al 1995Berman et al , 1998Lysaker et al 2000 ;Tibbo et al 2000 ;Fabisch et al 2001). It remains unclear if this reflects a true comorbidity, more severe illness or perhaps a unique diagnostic subcategory of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

et al. 2009

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Background. Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neurocircuitry.Method. We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness.Results. The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than statemarker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion.Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies.

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Section: Introductionmentioning

confidence: 99%

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

et al. 2009

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“…In a meta-analysis published in 2009, the incidence of obsessive-compulsive symptoms in schizophrenia patients was reported to range 10-64% and OCD frequency varied between 0.0-31.7% (13). It has been suggested that obsessive-compulsive symptoms are associated with earlier onset of schizophrenia, longer hospitalizations, lower levels of age-related functioning, lower rates of employment and marriage, and increased dependence on others (14). Another study reported that the age at onset of obsessivecompulsive symptoms was markedly earlier than the onset of psychotic symptoms and that the first psychotic symptoms started earlier in the schizoobsessive group (15).…”

Section: Discussionmentioning

confidence: 99%

Co-occurrence of autism spectrum disorder and very early onset schizophrenia: a case report

Kaba¹,

Uran²,

Aysev³

2017

Dusunen Adam

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Co-occurrence of autism spectrum disorder and very early onset schizophrenia: a case report Very early onset schizophrenia (VEOS) is a chronic and debilitating psychiatric disorder and has received too little attention in the medical literature. Previous studies have suggested that VEOS had a tendency of a worse prognosis and outcome than adult onset schizophrenia. Autism spectrum disorder (ASD) is a life-long impairing heterogeneous disorder, characterized by severe and pervasive impairments in multiple areas of psychological development. Co-occurrence of ASD and VEOS is reported very rarely in the literature. This paper reports on a case diagnosed as ASD with a VEOS comorbidity. With this case report, it is aimed to review the differential diagnosis, common and different clinical features, neuroimaging findings and genetic and environmental etiologies of these two psychopathologies in the light of the literature.

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“…1–3 Additionally, an elevated rate of OCD has been found in first episode and drug naïve patients with schizophrenia 1 , indicating that it is not accounted for by the course of the primary illness or antipsychotic medication alone. The presence of OCD or significant OCS in patients with schizophrenia has been associated with more severe psychosis 4 and depression 4 , poorer social functioning 2 , lesser likelihood of being employed 5 , and poorer prognosis. 5 …”

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confidence: 99%

Nonclinical Obsessive-Compulsive Symptoms and Executive Functions in Schizophrenia

Kumbhani¹,

Roth²,

Kruck³

et al. 2010

Journal of Neuropsychiatry

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The impact of non-clinical obsessive compulsive symptoms (OCS) on neuropsychological functioning in schizophrenia has received little investigation. We evaluated whether severity and subtype of OCS are associated with executive functioning in schizophrenia. Twenty-nine patients with schizophrenia and 32 healthy subjects completed questionnaire and performance-based measures of executive functioning Overall OCS severity in patients was associated with poorer monitoring and cognitive flexibility per a questionnaire. Obsessing, hoarding, and checking were related to poorer executive functioning in daily life. Performance-based scores showed few correlations with OCS. Findings indicate that severity of non-clinical OCS subtypes contribute to the heterogeneity of executive functions in schizophrenia.

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Obsessive and compulsive symptoms in chronic schizophrenia

Cited by 188 publications

References 14 publications

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

Co-occurrence of autism spectrum disorder and very early onset schizophrenia: a case report

Nonclinical Obsessive-Compulsive Symptoms and Executive Functions in Schizophrenia

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