Observer reproducibility in grading dysplasia in colorectal adenomas: comparison between two different grading systems.

Fenger, Claus; Bak, Martin; Kronborg, O; Svanholm, Hans

doi:10.1136/jcp.43.4.320

Cited by 33 publications

(15 citation statements)

References 16 publications

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“…The different importance assigned to nuclear dysplastic abnormalities (nuclear stratification, in particular) may explain the significantly different detection levels observed in this study between the two centres (40/457 and 54/457 cases versus 99/457 and 101/457 cases for optical and virtual microscopy, respectively). As previously demonstrated, when dysplasia grading is determined by architectural criteria, based on large areas, high grade is more easily and frequently identifiable at a lower magnification 14. Conversely, focusing on nuclear abnormalities in smaller areas and even barely identifiable epithelial tracts can fulfil the criteria for high-grade dysplasia, lowering the detection rate 3.…”

Section: Discussionmentioning

confidence: 97%

Virtual microscopy for histology quality assurance of screen-detected polyps

et al. 2010

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Section: Discussionmentioning

confidence: 97%

Virtual microscopy for histology quality assurance of screen-detected polyps

et al. 2010

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“…T h e remaining tissue was used for histopathologic examination. Classification and grading of the adenomas were performed according to World Health Organization (WHO) recommendations (Morson and Sobin, 1976), a system which, in our hands, has shown good reproducibility (Fenger et al, 1990). There were 11 tubular, 5 tubulovillous, and 1 villous adenoma.…”

Section: Methodsmentioning

confidence: 99%

Clonal karyotypic abnormalities in colorectal adenomas: Clues to the early genetic events in the adenoma‐carcinoma sequence

Bomme

Bardi

Pandis

et al. 1994

Genes Chromosomes & Cancer

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Cytogenetic analysis of short-term cultures from colorectal adenomas revealed acquired clonal chromosome aberrations in 14 of 17 tumors. In 4 adenomas, only numerical changes were found, whereas 10 had structural rearrangements. Trisomy 7 was found as the sole change in one of the tumors and together with other numerical changes in another. A +7 was also present in one case with structural aberrations. Other recurrent numerical aberrations were -14 and -18, both found in 2 adenomas with structural karyotypic changes; in addition, one chromosome 14 was lost in one of the tumors with only numerical changes. The chromosome most often involved in structural aberrations was chromosome 1. In 6 cases, the rearrangements led to changes in 1p, always with loss of material. The breakpoints were at 1p32-36. One adenoma had deletion of 1p as the only change. Other chromosomes that were involved in changes in more than 2 cases were chromosomes 8, 13, and 17. These rearrangements typically led to gain of 8q and 13q and loss of 17p. The adenomas with structural abnormalities were generally larger and had a higher degree of dysplasia than did the adenomas with numerical changes only or those with a normal karyotype. All adenomas with a tubulovillous or villous architecture had structural rearrangements. Our findings confirm that a subset of colorectal adenomas exists that have only numerical chromosome aberrations. They also support our previous conclusion that loss of material from distal 1p is an early event in colorectal tumorigenesis, but that other cytogenetic aberrations follow and typically are present already at the adenomatous stage.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…85,86 The kappa values between two pathologists ranged from 0.59 to 0.69 in tumour pathological diagnosis. [87][88][89] OS is able to permit non-invasive and objective analysis of biochemical and subcellular alterations of tissues, and the results are well correlated with histopathology. In the diagnosis of dysplasia in Barrett's oesophagus (BE), a high level of agreement (kappa value 0.89) was observed between spectral data and consensus opinion of pathology.…”

Section: Os Diagnosis Based On Tissuesmentioning

confidence: 99%

Biomedical optical spectroscopy for the early diagnosis of gastrointestinal neoplasms

2017

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Gastrointestinal cancer is a leading contributor to cancer-related morbidity and mortality worldwide. Early diagnosis currently plays a key role in the prognosis of patients with gastrointestinal cancer. Despite the advances in endoscopy over the last decades, missing lesions, undersampling and incorrect sampling in biopsies, as well as invasion still result in a poor diagnostic rate of early gastrointestinal cancers. Accordingly, there is a pressing need to develop noninvasive methods for the early detection of gastrointestinal cancers. Biomedical optical spectroscopy, including infrared spectroscopy, Raman spectroscopy, diffuse scattering spectroscopy and autofluorescence, is capable of providing structural and chemical information about biological specimens with the advantages of non-destruction, non-invasion and reagent-free and waste-free analysis and has thus been widely investigated for the diagnosis of oesophageal, gastric and colorectal cancers. This review will introduce the advances of biomedical optical spectroscopy techniques, highlight their applications for the early detection of gastrointestinal cancers and discuss their limitations.

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Observer reproducibility in grading dysplasia in colorectal adenomas: comparison between two different grading systems.

Abstract: The two most well known and well defined grading systems for dysplasia in colorectal adenomas were

Cited by 33 publications

References 16 publications

Virtual microscopy for histology quality assurance of screen-detected polyps

Virtual microscopy for histology quality assurance of screen-detected polyps

Clonal karyotypic abnormalities in colorectal adenomas: Clues to the early genetic events in the adenoma‐carcinoma sequence

Biomedical optical spectroscopy for the early diagnosis of gastrointestinal neoplasms

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