Observer design and tuning for biomass growth and kLa using online and offline measurements

Soons, Zita; Shi, Jun; Stigter, J.D.; Pol, Leo A. van der; Straten, G. van; Boxtel, A.J.B. van

doi:10.1016/j.jprocont.2007.12.008

Cited by 11 publications

(4 citation statements)

References 26 publications

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“…[8][9]. Each of these signals was used as input for the Extended Kalman Filter [17] to observe biomass and specific growth rate and finally to predict biomass concentrations (Eq. 10) to investigate the effect of the off-gas dynamics during real batch and fed-batch experiments.…”

Section: Resultsmentioning

confidence: 99%

“…An Extended Kalman Filter (EKF) was applied to estimate specific growth rate ðl tÀT D jt Þ and biomassĈ X;tÀT D jt À Á using the auxiliary oxygen uptake rate ðOUR a tÀT D jt Þ every minute [17].…”

Section: à ámentioning

confidence: 99%

“…An Extended Kalman Filter (EKF) was applied to estimate specific growth rate (l m ) and biomass C m X À Á using the oxygen uptake rate (OUR) every minute [17]. The EKF is based on the following model for biomass growth and oxygen consumption:…”

Section: Appendix 1: Monitoring and Controlmentioning

confidence: 99%

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Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller

Soons

IJssel²,

Pol³

et al. 2008

Bioprocess Biosyst Eng

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This study considers two aspects of the implementation of a biomass growth observer and specific growth rate controller in scale-up from small-to pilot-scale bioreactors towards a feasible bulk production process for whole-cell vaccine against whooping cough. The first is the calculation of the oxygen uptake rate, the starting point for online monitoring and control of biomass growth, taking into account the dynamics in the gas-phase. Mixing effects and delays are caused by amongst others the headspace and tubing to the analyzer. These gas phase dynamics are modelled using knowledge of the system in order to reconstruct oxygen consumption. The second aspect is to evaluate performance of the monitoring and control system with the required modifications of the oxygen consumption calculation on pilot-scale. In pilot-scale fed-batch cultivation good monitoring and control performance is obtained enabling a doubled concentration of bulk vaccine compared to standard batch production.

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Section: Resultsmentioning

confidence: 99%

Section: à ámentioning

confidence: 99%

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Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller

Soons

IJssel²,

Pol³

et al. 2008

Bioprocess Biosyst Eng

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“…The operation and monitoring of chemical processes requires reliable methods for continuous online control of running processes, determination of properties of liquids and gases, and determination of the response to changes in the process conditions. − One of the industrial processes that is receiving a lot of attention lately is postcombustion CO 2 capture (PCC), a technology aimed to reduce the carbon dioxide emissions to the atmosphere caused by the electric power industry, chemical industry, and heavy industry. − Chemical absorption is the current standard for PCC from power plants using amine-based solvents as the chemical absorption agent. − Counter-current flows of the amine-based solvent and the exhaust stream are brought into contact inside an absorber column, thus removing carbon dioxide from the flue gas. The resulting CO 2 -rich liquid solvent is pumped toward the thermal desorption column, where CO 2 gas is released from the solvent due to increased temperature.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Process Monitoring of CO₂ Capture by Aqueous AMP-PZ Using Chemometrics: Pilot Plant Demonstration

Kachko

Ham²,

Geers³

et al. 2015

Ind. Eng. Chem. Res.

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A combination of analytical instrumentation and multivariate statistics is widely applied to improve in-line process monitoring. Currently, postcombustion CO2 capture (PCC) technology often involves the use of multiamine based chemical reagents for carbon dioxide removal from flue gas. The CO2 capture efficiency and overall process performance may be improved by introduction of the chemometrics analytical methods for flexible and reliable process monitoring. In this study, six variables were measured (conductivity, pH, density, speed of sound, refractive index, and near-infrared absorbance spectra). A compact data-collecting chemometric setup was constructed and installed at an industrial pilot plant for real-case testing. This setup was applied to the characterization of CO2 absorption into aqueous 2-amino-2-methyl-1-propanol (AMP) activated by piperazine (PZ) as the absorption agent. A partial least-squares (PLS) regression model was calibrated and validated based on the measurements conducted in the laboratory environment. The developed approach was applied to predict the concentrations of AMP, PZ, and CO2 with accuracies of ±2.1%, ± 3.5%, and ±4.3%, respectively. The model was constructed to include the temperature dependency in order to make it insensitive to operational temperature fluctuations during a CO2 capture process. The setup and model have been tested for almost 850 hours of in-line measurements at a postcombustion CO2 capture pilot plant. To provide validation of the chemometrics approach, an off-line analysis of the samples has been conducted. The results of the validation technique benchmarking appear to be consistent with values predicted in-line, with average deviations of ±1.8%, ± 1.3%, and ±3.9% for the concentrations of AMP, PZ, and CO2, respectively.

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Adaptive control and signal processing literature survey (No. 5)

2008

Adaptive Control & Signal

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In order to keep readers up to date, the journal will contain a list of recently published journal articles relevant to the fields of adaptive control and signal processing six times a year. This list is compiled from a wide range of journals. Please note that even though the list has been broadly categorized these classifications are by no means strict, and are there to assist the reader. Please also note that inclusion in the list is not an endorsement of a paper's quality. If you have any suggestions or comments, please

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Observer design and tuning for biomass growth and kLa using online and offline measurements

Cited by 11 publications

References 26 publications

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller

Real-Time Process Monitoring of CO₂ Capture by Aqueous AMP-PZ Using Chemometrics: Pilot Plant Demonstration

Adaptive control and signal processing literature survey (No. 5)

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Observer design and tuning for biomass growth and kLa using online and offline measurements

Cited by 11 publications

References 26 publications

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller

Real-Time Process Monitoring of CO2 Capture by Aqueous AMP-PZ Using Chemometrics: Pilot Plant Demonstration

Adaptive control and signal processing literature survey (No. 5)

Contact Info

Product

Resources

About

Real-Time Process Monitoring of CO₂ Capture by Aqueous AMP-PZ Using Chemometrics: Pilot Plant Demonstration