Abstract:This study considers two aspects of the implementation of a biomass growth observer and specific growth rate controller in scale-up from small-to pilot-scale bioreactors towards a feasible bulk production process for whole-cell vaccine against whooping cough. The first is the calculation of the oxygen uptake rate, the starting point for online monitoring and control of biomass growth, taking into account the dynamics in the gas-phase. Mixing effects and delays are caused by amongst others the headspace and tub… Show more
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