Observer‐blind randomized controlled study of a cosmetic blend of safflower, olive and other plant oils in the improvement of scar and striae appearance

Abstract

OBJECTIVE:The normal process of skin tissue repair following injury invariably results in visual scarring. It is known that topical treatment with hydrophobic cosmetics rich in silicone and mineral oil content can improve the appearance of scars and striae. Given lifestyle preferences of many cosmetic consumers towards so-called natural treatments, the objective of this controlled randomized study was to investigate the efficacy of a plant body oil rich in oleic and linoleic acids (Bio Skin Oil â ) for improving the appearance of scars and striae. METHODS: A panel of 80 volunteers with non-hypertrophic scars (40) or stretch marks (40) not older than 3 years applied a cosmetic face and body oil for 8 weeks. Compared to an untreated scar/stretch mark region, a blinded investigator as well as volunteer assessments with given observed parameters demonstrated the efficacy of the oil under test. RESULTS: On the Observer Scar Assessment Scale (OSAS), the mean score was reduced on the product-treated area by approximately 5% (P = 0.006). The untreated area remained unchanged. Observed effects by volunteers were more pronounced -Patient Scar Assessment Scale (PSAS) giving a reduction of approximately 20% on the treated area, and on the control untreated area a reduction of approximately 6%. The overall product effect of 14% was shown to be clearly significant (P = 0.001). All statements relating to product traits achieved higher frequencies of agreements than of non-agreements and were therefore assessed positively by the volunteers. Highest frequencies of agreements occurred in statements that the test product provides a long-lasting, soft and supple skin feeling (93%); caring effect (87%); and quick absorbance (84%). Agreement was also found for statements that the product improves the skin appearance (61%) and that scars/striae appear less pronounced (51%). Only 17% of volunteers felt the oil had no benefit to the appearance of their scars/striae. CONCLUSIONS: The oil blend under test is effective in improving the appearance of non-keloid scars and striae. Further work is required to understand the mechanisms of how plant oil fatty acids ameliorate scar and striae appearance. ESULTATS: Sur l' echelle OSAS (« Observer Scar Assessment Scale »), le r esultat moyen a et e diminu e d'environ 5% (p = 0,006) sur la zone trait ee par le produit. La zone non trait ee est demeur ee inchang ee. Sur l' echelle PSAS (« Patient Scar Assessment Scale »), les effets observ es par les volontaires ont et e plus notables, permettant une r eduction d'approximativement 20% sur la zone trait ee, et une diminution de 6% sur la zone de contrôle non-trait ee. Les 14% d'effet global du produit sont clairement significatifs (p = 0,001). Toutes les affirmations relatives aux caract eristiques du produit ont rec ßu davantage d'accords que de d esaccords et ont par cons equent fait l'objet d'une evaluation positive par les volontaires. Les points d'accord ont concern e en majorit e les affirmations sur le produit relatives a une sensation...

Recovery of phytochemical from three safflower ( Carthamus tinctorius L.) by‐products: Antioxidant properties, protective effect of human erythrocytes and profile by UPLC‐DAD‐MS

“…colorant (Bhogaita et al,2016). In Germany, oil of the seed is used as an active principle of cosmetic formulations (Bielfeldt et al, 2018).…”

Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebo‐controlled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants

“…More recently, a study on a plant cosmetic oil, consisting mainly of linoleic and oleic acids from Safflower and olive oils, revealed its potential benefits of improving the aspect of SD, in a panel of 80 volunteers presenting nonhypertrophic scars or stretch marks after 8 weeks of treatment. 22 Similarly, daily applications for 6 weeks of a plant cream containing P. granatum seed oil and C. lechleri resin extracts showed an increase in dermal thickness, hydration, and elasticity on both healthy skin and stretch mark areas in 20 volunteers. 23 Even though clinical benefits of the reduction of stretch marks were observed in these studies, the mechanisms by which these topical preparations can improve their appearance were not completely described.…”

“…In fact, very few clinical studies present a robust and rigorous methodology and demonstrate clear benefits of topical preparations in eradicating or improving the appearance of SD. More recently, a study on a plant cosmetic oil, consisting mainly of linoleic and oleic acids from Safflower and olive oils, revealed its potential benefits of improving the aspect of SD, in a panel of 80 volunteers presenting nonhypertrophic scars or stretch marks after 8 weeks of treatment 22 . Similarly, daily applications for 6 weeks of a plant cream containing P. granatum seed oil and C. lechleri resin extracts showed an increase in dermal thickness, hydration, and elasticity on both healthy skin and stretch mark areas in 20 volunteers 23 .…”

Validação De Instrumento Para Cuidado Da Pessoa Idosa Com Xerose Cutânea

“…Em contrapartida, com a disponibilidade de produtos naturais, temse elevado o uso de produtos à base de óleos ricos em ácido linoleico e outros ácidos graxos poli-insaturados. Os mecanismos pelos quais esses ácidos graxos atuam variam de mudanças na organização do colágeno à inibição de mediadores pós-inflamatórios, além de auxiliarem na normalização da integridade e do desenvolvimento do estrato córneo (23) .…”