Observed relationship between ratios HDL-cholesterol/total cholesterol and apolipoprotein A1/apolipoprotein B

Kuyl, Johan M.; Mendelsohn, D

doi:10.1016/0009-9120(92)80004-z

Cited by 25 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dyslipidemia is another crucial risk factor. All of the main phenotypic expressions of dyslipidemia (hypercholesterolemia, 22,23) hypertriglyceridemia, 22) low HDL-fraction level, 29) and high apoliproprotein B 1 /A ratio 30) ) were more prevalent in the Cimbrians than in the SCP (Table III), particularly in women. The hypothesis that the direct association between hypercholesterolemia and the risk of CAD becomes less robust with increasing age 31) is under debate, but in the Italian general population -and particularly in the geographic area where the Leogra and the CASTEL studies were performed -cholesterol continues to play a role in predicting coronary mortality even after the age of 65, at least in men and specially in those who smoke.…”

Section: Discussionmentioning

confidence: 99%

German Origin Clusters for High Cardiovascular Risk in an Italian Enclave

Casíglia

Basso²,

Guglielmi

et al. 2005

Int. Heart J.

View full text Add to dashboard Cite

SUMMARYMortality and morbidity appear to be higher in a Cimbrian population representing an enclave of people who migrated from medieval Germany to the secluded Leogra valley in Italy.A population-based study was organized, recruiting 881 elderly subjects of Cimbrian origin and comparing them with a standard control population (SCP, n = 3282) having comparable general characteristics and lifestyle. Serum lipids and glucose, blood pressure, heart rate, respiratory function, ECG abnormalities, and historical events were used as risk indicators.Age-adjusted systolic and pulse pressure were higher in the Cimbrians than in the SCP, while diastolic blood pressure was comparable. The prevalences of arterial hypertension, isolated systolic hypertension, and pulse hypertension were significantly more represented among Cimbrians than SCP. The prevalences of diabetes, hypercholesterolemia, and hypertriglyceridemia were higher among the former than the latter. The ratio between apolipoproteins B and A1 was also higher, while the HDL fraction was significantly lower in Cimbrians than in the SCP. In Cimbrians, the relative risk (RR) for ischemic heart disease was 1.92 (1.57-2.34) in women, 2.30 (1.54-3.43) in men and 1.03 (1.00-1.06) in women for stroke, 2.43 (1.54-3.83) in men and 1.45 (1.01-1.12) in women for atrial fibrillation, 3.85 (2.83-5.24) in men and 1.39 (1.20-1.60) in women for respiratory disease, 1.97 (1.32-2.94) in men and 6.81 (4.38-10.60) in women for intermittent claudication, and 3.31 (2.44-4.50) in men and 2.30 (1.76-3.01) in women for left ventricular hypertrophy.The subjects living in the secluded Leogra valley are at higher cardiovascular risk than the standard controls. Whether this depends on genetic factors, lifestyle, or both will need to be clarified by further analysis. (Int Heart J 2005; 46: 489-500)

show abstract

Section: Discussionmentioning

confidence: 99%

German Origin Clusters for High Cardiovascular Risk in an Italian Enclave

Casíglia

Basso²,

Guglielmi

et al. 2005

Int. Heart J.

View full text Add to dashboard Cite

show abstract

“…Apolipoprotein A-1 accounts for almost 70% of the HDL mass and transports cholesterol from tissues to the liver, forming protection from atherosclerotic processes (39). …”

Section: Genetics Of Non-conventional Lipoprotein Fractionsmentioning

confidence: 99%

Genetics of Non-conventional Lipoprotein Fractions

Frazier‐Wood

2015

Curr Genet Med Rep

View full text Add to dashboard Cite

Lipoprotein subclass measures associate with cardiometabolic disease risk. Currently the information that lipoproteins convey on disease risk over that of traditional demographic and lipid measures is minimal, and so their use is clinics is limited. However, lipoprotein subclass perturbations represent some of the earliest manifestations of metabolic dysfunction, and their etiology is partially distinct from lipids, so information on the genetic etiology of lipoproteins offers promise for improved risk prediction, and unique mechanistic insights into IR and atherosclerosis. Here, I review the genetic variants validated as associating with lipoprotein measures to date, and show that the majority of identified variants have functionality that is best understood as related to lipid measures. Until we focus on the genes as they relate to lipoprotein subclass production, we are limiting our understanding of biological mechanisms underlying cardiometabolic disease.

show abstract

“…Apo A1 plays a crucial role in the regulation of reverse cholesterol transport [167–169]. Upon secretion into plasma, Apo A1 is lapidated through ATP-binding cassette transporter-(ABC-)A1 that mediated efflux of free cholesterol and phospholipids, resulting in the formation of nascent disc shaped HDL particles [170].…”

Section: Apolipoprotein A1mentioning

confidence: 99%

Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

et al. 2011

View full text Add to dashboard Cite

Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described.

show abstract

Observed relationship between ratios HDL-cholesterol/total cholesterol and apolipoprotein A1/apolipoprotein B

Cited by 25 publications

References 10 publications

German Origin Clusters for High Cardiovascular Risk in an Italian Enclave

German Origin Clusters for High Cardiovascular Risk in an Italian Enclave

Genetics of Non-conventional Lipoprotein Fractions

Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

Contact Info

Product

Resources

About