Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

Curti, Maíra Ladeia Rodrigues; Jacob, Patricia; Borges, Maria Carolina; Rogero, Marcelo Macedo; Ferreira, Sandra Roberta Gouvêa

doi:10.1155/2011/497401

Cited by 57 publications

(50 citation statements)

References 247 publications

(254 reference statements)

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“…After its activation, PPARg modulates lipid metabolism (Curti et al 2011) and the inflammatory response (Celinski et al 2012, Rezvanfar et al 2012, whereas, during folliculogenesis, PPARg modulates steroidogenesis and cellular proliferation (Froment et al 2006). Given the important role of the PPARg system in modulating endocrine and metabolic pathways, the management of the PPARg system represents a fundamental tool in treating metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Effect of hyperandrogenism on ovarian function

et al. 2015

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The objective of this work was to study the ovarian function when follicular development is induced during a hyperandrogenic condition. Female rats were injected with either equine chorionic gonadotropin (eCG group) to induce folliculogenesis or eCG together with DHEA to induce folliculogenesis in a hyperandrogenic condition (eCGCHA group). The control group was injected with vehicle. Ovarian mRNA levels of the peroxisome proliferator-activated receptor gamma (PPARg) co-activator PGC1a, the PPARg co-repressor NCoR, the main enzymes involved in the ovarian steroidogenesis (CYP17, 3b-hydroxysteroid dehydrogenase (3b-HSD), 17b-HSD, and CYP19A), and cyclooxygenase 2 (COX2) were evaluated only by real-time PCR. COX2 was evaluated by both real-time PCR and western blot. Serum steroid hormones and both the oxidative and inflammatory statuses were also quantified. We found that eCG-induced folliculogenesis induced increased mRNA levels of PGC1a and decreased those of NCoR when compared with controls. In addition, we found an increase in serum estradiol (E 2 ) levels and enhanced mRNA expression of CYP19A. A pro-inflammatory status and a pro-oxidant status were also established. When folliculogenesis was induced in a hyperandrogenic condition, the mRNA levels of the PPARg co-repressor NCoR remained higher than in controls and the pro-inflammatory and pro-oxidant statuses were enhanced. In addition, the enzymes involved in ovarian steroidogenesis were altered leading to the accumulation of testosterone and an unfavorable E 2 /testosterone ratio. These alterations led to abnormal follicular development.

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Section: Introductionmentioning

confidence: 99%

Effect of hyperandrogenism on ovarian function

et al. 2015

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“…Basal levels of different cytokines and the magnitudes of their increases during inflammation vary between individuals and are under the influence of both different gene variants and environmental factors, e.g. such nutrition [9,10]. …”

Section: Introductionmentioning

confidence: 99%

Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study

Bromander

Anckarsäter

Kristiansson

et al. 2012

J Neuroinflammation

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BackgroundSurgery launches an inflammatory reaction in the body, as seen through increased peripheral levels of cytokines and cortisol. However, less is known about perioperative inflammatory changes in the central nervous system (CNS).Our aim was to compare inflammatory markers in serum and cerebrospinal fluid (CSF) before and after surgery and evaluate their association with measures of blood–brain barrier (BBB) integrity.MethodsThirty-five patients undergoing knee arthroplastic surgery with spinal anesthesia had CSF and serum samples drawn before, after and on the morning following surgery. Cytokines and albumin in serum and CSF and cortisol in CSF were assessed at all three points.ResultsCytokines and cortisol were significantly increased in serum and CSF after surgery (Ps <0.01) and CSF increases were greater than in serum. Ten individuals had an increased cytokine response and significantly higher CSF/serum albumin ratios (Ps <0.01), five of whom had albumin ratios in the pathological range (>11.8). Serum and CSF levels of cytokines were unrelated, but there were strong correlations between CSF IL-2, IL-10 and IL-13, and albumin ratios (Ps <0.05) following surgery.ConclusionCytokine increases in the CNS were substantially greater than in serum, indicating that the CNS inflammatory system is activated during peripheral surgery and may be regulated separately from that in the peripheral body. CSF cytokine increase may indicate sensitivity to trauma and is linked to BBB macromolecular permeability.

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“…zsírszövetben, és elvezet az inzulinrezisztencia kialakulá-sához, befolyásolva a gyulladást és az elhízást [23,24]. Az oxigéngyökök hosszabb élettartamú hidrogén-peroxiddá (H 2 O 2 ) konvertálódnak, amely indukálja a további pro-gyulladásos citokinek felszabadulását.…”

Section: Eredeti Közleményunclassified

Az elhízás anyagcsere-szövődményei serdülőkorban, különös tekintettel az emelkedett húgysavszintek előfordulására

et al. 2015

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Bevezetés: Az elhízás társadalmi problémát jelent világszerte, amely elvezet több betegséghez, beleértve a metabolikus szindrómát, hypertoniát és a cardiovascularis betegségeket. Ismert tény, hogy a hyperurikaemia felnőttkorban össze-kapcsolódhat e betegségekkel. Célkitűzés: A metabolikus szindróma és a hyperurikaemia gyakoriságának és ezek összefüggésének vizsgálata elhízott serdülők körében. Módszer: A szerzők keresztmetszeti tanulmányukban 162 (100 fi ú, 62 lány) túlsúlyos vagy elhízott serdülő adatait elemezték, akiket korábban a gyermekgyógyászati endokrinoló-giakonzultáción kivizsgáltak. Antropológiai és metabolikus paramétereket értékeltek valamennyi személynél. Kontrollként egészséges, azonos életkorú, nem elhízott 20 leány és 26 fi ú adatait használták. A betegek életkora fi úknál 12±2,1 év, lányoknál 11±2,5 év, a kontrollfi úk életkora 12,9±2,5 év, a lány kontrollcsoport életkora 13,2±1,6 év volt. A szerzők lineáris regressziót alkalmaztak a húgysavszint és a metabolikus szindróma egyes klinikai és laboratóriumi eredményei közötti összefüggések vizsgálatára. Eredmények: Az elhízott személyeknél nagyobb volt a BMI-SDS ( fi úknál 3,4±1,3 vs. 0,05±0,4, p<0,0001; lányoknál 3,75±1,4 vs. 0,72±0,9, p = 0,0001), a derékbőség (fi úknál 90,1±9,2 vs. 82,3±6,4 cm; lányoknál 90,2±8,6 vs. 78,1±7,2 cm, p<0,001), a szisztolés vérnyomás (fi úknál 125±14,3 vs. 118,2±10,8 Hgmm, p = 0,02; lányoknál 125,8±11,8 vs. 119,8±8,8 Hgmm, p<0,01), a diasztolés vérnyomás ( fi úknál 78,4±9,1 vs. 71,2±8,0 Hgmm, p = 0,0003; lányoknál: 76,45±7,2 vs. 73,2±6,3 Hgmm, p = 0,0453), mint a kontrolloknál. A metabolikus szindróma prevalenciája 45/162 (27,8%), a hyperurikaemia prevalenciája 62/162 (38,3%) volt. A metabolikus szindrómás betegek között 30 esetben (66,7%-ban) igazoltak hyperurikaemiát. Követ-keztetések: Megállapították, hogy a hyperurikaemia szoros összefüggésben van a metabolikus szindrómával. A húgysav magas koncentrációja előre jelzi a cardiovascularis kockázatot felnőttkorban. Fontos a gyermekgyógyászok számára, hogy meghatározzák és értékeljék a húgysavszinteket a túlsúlyos és elhízott gyermekeknél. Orv. Hetil., 2015, 156(22), 888-895. Kulcsszavak: elhízás, metabolikus szindróma, inzulinrezisztencia, hyperurikaemia Metabolic complications of obesity during adolescence, in particular to elevated uric acid levelsIntroduction: Obesity is a social problem worldwide that leads to several diseases, including metabolic syndrome, hypertension and cardiovascular diseases. It is known that hyperuricemia in adults may be associated with these disorders. Aim: The aim of the authors was to investigate the frequency of metabolic syndrome and hyperuricemia and their relationship among obese adolescents. Method: This was a cross-sectional study. The authors analysed the data of 162 overweight or obese adolescents (100 boys and 62 girls) who were previously investigated in a paediatric endocrinology consultation. Anthropometric and metabolic parameters were evaluated in all subjects. Healthy, agematched, non obese girls (n = 20) and boys (n = ...

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Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

Cited by 57 publications

References 247 publications

Effect of hyperandrogenism on ovarian function

Effect of hyperandrogenism on ovarian function

Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study

Az elhízás anyagcsere-szövődményei serdülőkorban, különös tekintettel az emelkedett húgysavszintek előfordulására

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