Observed Externalizing Behavior: A Developmental Comparison of Genetic and Environmental Influences Across Three Samples

Marceau, Kristine; Humbad, Mikhila N.; Burt, S. Alexandra; Klump, Kelly L.; Leve, Leslie D.; Neiderhiser, Jenaè M.

doi:10.1007/s10519-011-9481-2

Cited by 11 publications

(8 citation statements)

References 42 publications

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“…The exogenous dimension of depression as shown by the study and externalizing problems (i.e., drop in school performance, school work difficulty, disobedience, fighting, misbehavior) was less heritable and showed significant shared environmental etiologies. The small heritable component in this dimension may reflect genetic influences on externalizing behaviors that were also influenced by shared environmental factors (Marceau et al., ; Moffitt, ). Interestingly, the anhedonia dimension, which was supposed to be an endophenotype of depression, was subject to minimal genetic influence but substantial environmental influences in the current study.…”

Section: Discussionmentioning

confidence: 99%

Etiological heterogeneity of symptom dimensions of adolescent depression

Chen

Zhang

et al. 2014

PsyCh Journal

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The aim was to investigate the underlying factor structure of adolescent depression and etiological heterogeneity in the symptom dimensions of adolescent depression. The sample included 842 pairs of same-sex adolescent twins, among which 613 pairs were monozygotic twins and 229 pairs were dizygotic twins. The ages of the participants ranged from 11 to 17 years (M = 13.64, SD = 1.80). Adolescents' depressive symptoms were assessed using the self-reported Children's Depression Inventory. Exploratory and confirmatory factor analyses were used to explore the factor structure of youth depression and twin genetic analyses were employed to estimate genetic and environmental influences on the derived dimensions. Results showed that adolescent depression encompassed five correlated dimensions: dysphoria mood, somatic symptoms, study and externalizing problems, anhedonia symptoms, and cognitive symptoms. These five symptom dimensions had heterogeneous etiologies: Dysphoria mood, somatic symptoms, and cognitive symptoms were moderately heritable (heritability ranged from 33 to 40%), whereas study and externalizing problems, and anhedonia symptoms were mainly environmentally influenced with minimal genetic basis. Our findings supported the multidimensionality of adolescent depression and the etiological heterogeneity of these symptom dimensions.

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Section: Discussionmentioning

confidence: 99%

Etiological heterogeneity of symptom dimensions of adolescent depression

Chen

Zhang

et al. 2014

PsyCh Journal

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“…In doing so, we make use of several measurement strategies: parent- and child-informant reports, videotaped parent–child, family, and spousal interactions, and the assessment of an independent sample of neighborhood informants from each twin family’s neighborhood. The TBED-C has already produced several published papers (Burt & Klump, 2012, in press-a; Burt et al, 2012; Humbad et al, 2011; Klahr et al, in press; Marceau et al, 2012; Nikolas et al, 2012, in press), with many more under review and in preparation.…”

Section: Msutr Projectsmentioning

confidence: 99%

“…Observational as well as survey methods comprise our assessments of parent–child, familial, and spousal relationships. This multi-method approach allows us to more rigorously define our phenotype (Burt, 2012; Burt & Klump, 2012), examine informant effects on heritability estimates (Marceau et al, 2012; Nikolas et al, in press), and obtain a more fine-tuned understanding of environmental risks and their contributions to psychiatric outcomes (Burt et al, 2012; Burt & Klump, in press-a, 2012; Nikolas et al, 2012). …”

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confidence: 99%

The Michigan State University Twin Registry (MSUTR): An Update

2012

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The primary aim of the Michigan State University Twin Registry (MSUTR) is on understanding developmental changes in genetic, environmental, and neurobiological influences on internalizing and externalizing disorders, with antisocial behavior and disordered eating representing our particular areas of interest. The MSUTR has two broad components: a large-scale, population-based registry of child, adolescent, and adult twins and their families (current N ~20,000) and a series of more focused and in-depth studies drawn from the registry (current N ~4,000). Participants in the population-based registry complete a family health and demographic questionnaire via mail. Families are then recruited for one or more of the intensive, in-person studies from the population-based registry based on their answers to relevant items in the registry questionnaire. These in-person assessments target a variety of biological, genetic, and environmental phenotypes, including multi-informant measures of psychiatric and behavioral phenotypes, census and neighborhood informant reports of twin neighborhood characteristics, buccal swab and salivary DNA samples, assays of adolescent and adult steroid hormone levels, and/or videotaped interactions of child twin families. This article provides an overview of the MSUTR and describes current and future research directions.

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“…To date, there are several twin studies examining etiological influences on observer‐ratings of acting‐out behaviors (Arsenault et al, 2003; Deater‐Deckard, 2000; Leve, Winebarger, Fagot, Reid, & Goldsmith, 1998; Marceau et al, 2010; O’Connor, Hetherington, Reiss, & Plomin, 1995; Plomin, Foch, & Rowe, 1981). Early work by Plomin et al (1981), Leve et al (1998), and Deater‐Deckard (2000) estimated shared environmental influences on observer‐ratings to be moderate to large in magnitude (25–42%).…”

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confidence: 99%

Confirming the etiology of adolescent acting-out behaviors: an examination of observer-ratings in a sample of adoptive and biological siblings

Burt¹,

Klahr²,

Rueter³

et al. 2010

Journal of Child Psychology and Psychiatry

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Background A recent meta-analysis revealed moderate shared environmental influences (C) on most forms of child and adolescent psychopathology (Burt, 2009), including antisocial behavior. Critically, however, the research analyzed in this meta-analysis relied largely on specific informant-reports (and particularly parent and child reports), each of which are subject to various sources of rater bias. Observer-ratings of children's behaviors avoid many of these biases, and are thus well-suited to verify the presence of C. Given this, we sought to buttress the evidence supporting C in two key ways. First, we sought to confirm that C contributes to observer-ratings in a sample of adoptive siblings, as similarity between adoptive siblings constitutes a “direct” estimate of C. Second, we sought to confirm that these shared environmental influences persist across informants (i.e., the effects are not specific to the rater or the context in question). Methods The current study examined the etiology of observer-ratings of acting-out behaviors, as well as sources of etiological overlap across observer-ratings, adolescent self-report and maternal-report in sample of over 600 biological and adoptive sibling pairs from the Sibling Interaction and Behavior Study (SIBS). Results Results revealed moderate and significant shared environmental influences on observer-ratings (31%), as well as on the other informant-reports (20-23%). Moreover, a portion of these effects overlapped across measures (C correlations ranged from .32-.34). Conclusions Such findings argue against passive rGE and rater bias as primary explanations for earlier findings of C on antisocial behavior, and in this way, offer a critical extension of prior work indicating that the role of shared environmental influences on child and adolescent antisocial behavior was dismissed too soon.

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Observed Externalizing Behavior: A Developmental Comparison of Genetic and Environmental Influences Across Three Samples

Cited by 11 publications

References 42 publications

Etiological heterogeneity of symptom dimensions of adolescent depression

Etiological heterogeneity of symptom dimensions of adolescent depression

The Michigan State University Twin Registry (MSUTR): An Update

Confirming the etiology of adolescent acting-out behaviors: an examination of observer-ratings in a sample of adoptive and biological siblings

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