Observations on Urocanic Acid and Formiminoglutamic Acid Excretion in Infants with Protein Malnutrition

Spector, I.; Falcke, H. C.; Yoffe, Yvonne; Metz, J.

doi:10.1093/ajcn/18.6.426

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…Our present work continues, but so far it seems that our results support the observations o f Satoskar et al (1962) and Spector et al (1966). Since not all the protein-malnourished children with high serum vitamin B i2 levels had enlarged livers, we recommend that other diagnostic methods to assess liver damage should accompany measurement o f serum vitamin B 12.…”

Section: Discussionsupporting

confidence: 87%

“…Satoskar et al (1962) were able to correlate the incidence o f liver damage with high serum vitamin B i2 levels among protein-malnourished children in India. Spector et al (1966) confirmed this and they suggested that raised serum vitamin B )2 could serve as a diagnostic index for the liver damage that accom panies protein malnutrition. Their argument was based on the fact that the damage done to the liver would interfere with the storage o f the vitamin in the liver.…”

Section: Discussionmentioning

confidence: 76%

“…A similar difference has been reported by various workers (Satoskar et ai. , 1962;Spector et al, 1966: Khalil et a i, 1973.…”

Section: Discussionmentioning

confidence: 99%

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Serum Vitamin B<sub>12</sub> Levels in Protein-Malnourished Children

Osifo¹,

Adadevoh²

1976

Ann Nutr Metab

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Serum vitamin B₁₂ levels were assayed in 25 healthy and 35 protein-malnourished children aged 1 -6 years. Serum proteins and haematocrit values of the children were also measured. Liver enlargement was estimated clinically. The mean serum vitamin B₁₂ activity among protein-malnourished children was slightly higher than that for the control group. Serum vitamin B₁₂ activity of the healthy Nigerian children was, however, high, and possible reasons for this are discussed in detail. There was some correlation between very high serum vitamin B₁₂ levels among the protein-malnourished children and incidence of liver enlargement.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 76%

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Serum Vitamin B<sub>12</sub> Levels in Protein-Malnourished Children

Osifo¹,

Adadevoh²

1976

Ann Nutr Metab

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“…Panders and Rupert (1965) have shown that an increase o f 2 °C produced an inhibitory effect on the reduction of folate to tetrahydrofolate in vitro. Spector et al (1966) also observed that children suffering from febrile infections without megaloblastic erythropoiesis excreted excessive urinary FIGlu. Their observation showed that there was inadequate folate to react with the FIGlu from histidine metabolism as shown below.…”

Section: Discussionmentioning

confidence: 94%

“…This observation was confirmed by Spector et al, (1966). They found that children who had febrile infections without megalo blastic erythropoiesis excreted three times the amount of formiminoglutamic acid (FlGlu) a urinary metabolite o f folate deficiency -as did children without febrile infections.…”

Section: Introductionmentioning

confidence: 83%

Effect of Folate Supplementation and Malaria on the Folate Content of Human Milk

Osifo¹,

Onifade²

1980

Ann Nutr Metab

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The concentration of folate in human milk was estimated in two groups of lactating mothers. The first group had no folate supplementation throughout pregnancy and the other group had 5 mg folate/day throughout the last trimester. Concentration of folate was significantly higher in the milk of mothers who had supplementation. There was a significant increase in folate concentration as the milk progressed to maturity. When malaria was present, there was no significant increase in the concentration of folate in the milk. Human milk is low in folate, and a rise in body temperature seems to disturb folate metabolism.

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Urocanate as a potential signaling molecule for bacterial recognition of eukaryotic hosts

Zhang

Ritchie

Rainey

2013

Cell. Mol. Life Sci.

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Host recognition is the crucial first step in infectious disease pathogenesis. Recognition allows pathogenic bacteria to identify suitable niches and deploy appropriate phenotypes for successful colonization and immune evasion. However, the mechanisms underlying host recognition remain largely unknown. Mounting evidence suggests that urocanate-an intermediate of the histidine degradation pathway-accumulates in tissues, such as skin, and acts as a molecule that promotes bacterial infection via molecular interaction with the bacterial regulatory protein HutC. In Gram-negative bacteria, HutC has long been known as a transcriptional repressor of hut genes for the utilization of histidine (and urocanate) as sources of carbon and nitrogen. Recent work on the opportunistic human pathogen Pseudomonas aeruginosa and zoonotic pathogen Brucella abortus shows that urocanate, in conjunction with HutC, plays a significant role in the global control of cellular metabolism, cell motility, and expression of virulence factors. We suggest that in addition to being a valuable source of carbon and nitrogen, urocanate may be central to the elicitation of bacterial pathogenesis.

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Observations on Urocanic Acid and Formiminoglutamic Acid Excretion in Infants with Protein Malnutrition

Cited by 13 publications

References 27 publications

Serum Vitamin B<sub>12</sub> Levels in Protein-Malnourished Children

Serum Vitamin B<sub>12</sub> Levels in Protein-Malnourished Children

Effect of Folate Supplementation and Malaria on the Folate Content of Human Milk

Urocanate as a potential signaling molecule for bacterial recognition of eukaryotic hosts

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