Observations on the Use of Plasma, Hair and Tissue to Evaluate Trace Element Status in Cancer

Borella, Paola; Bargellini, Annalisa; Caselgrandi, Eva; Piccinini, L

doi:10.1016/s0946-672x(97)80046-6

Cited by 45 publications

(34 citation statements)

References 16 publications

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“…Studies on micronutrients have established reduced levels associated with different malignancies like bcarotene, vitamin E, and vitamin C in lung cancer [23], gastric cancer [24], and pancreatic cancer [25]; vitamin A and C in oesophageal cancer [26]; Se and Zn in breast cancer [27,28], b-carotene in oral cancer [29] and thyroid cancer [30]; vitamin C, vitamin D, and calcium in carcinoma colon [31]; Zn, vitamin C, and vitamin E in prostate cancer [32]; folic acid in carcinoma cervix [33]; and Se in hepatocellular carcinoma [34]. We have found low serum, biliary, and tissue concentration of Se, Zn, and vitamin E in patients with carcinoma of the gallbladder as compared to cholelithiasis and the difference was found to be highly significant (P < 0.0001) between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Micronutrients, antioxidants, and carcinoma of the gallbladder

Shukla

Adukia

Singh

et al. 2003

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Micronutrients, antioxidants, and carcinoma of the gallbladder

Shukla

Adukia

Singh

et al. 2003

Journal of Surgical Oncology

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“…A recent prevention trial also demonstrates a small but significant increase in breast cancer in women given selenium [Clark, 1996]. In breast tissue, the selenium content is approximately 1 ug/gm dry weight of tissue and is significantly higher in malignant breast tissue than in normal breast tissue [Garg, 1994;Rizk and Sky-Peck, 1984;Borella, 1997]. Plasma also contains significant amounts of selenium, approximately 100 ng/ml [Overvad, 1991;Gupta, 1994].…”

Section: Discussionmentioning

confidence: 99%

Effects of selenite on estrogen receptor-? expression and activity in MCF-7 breast cancer cells

2000

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To determine whether selenite has estrogen-like activities, the effects of this compound on estrogen receptor-alpha (ER-alpha) and other estrogen-regulated genes were measured in the human breast cancer cell line MCF-7. Treatment of cells with 1 uM of sodium selenite resulted in a 40% decrease in the amount of estrogen receptor-alpha and in a parallel decrease of 40% in ER-alpha mRNA. Progesterone receptor concentration increased 2.6-fold and pS2 mRNA increased 2.4-fold after selenite treatment. The induction of progesterone receptor and pS2 was blocked by the anti-estrogen ICI-182,780. In transient co-transfection experiments of Wild-type ER-alpha and an estrogen response element-reporter construct, selenite stimulated CAT activity. In binding assays, selenite blocked the binding of estradiol to ER-alpha (K(i) = 23 +/- 17 nM, n = 3) suggesting that this compound interacts with the hormone binding domain of the receptor. To determine whether interaction of selenite with the hormone binding domain results in receptor activation, COS-1 cells were transiently co-transfected with the chimeric receptors GAL-ER, which contains the hormone binding domain of ER-alpha and the DNA binding domain of the transcription factor GAL4, and a GAL4-responsive CAT reporter gene. Treatment of cells with estradiol or selenite resulted in a three- to five-fold increase in CAT activity. The effects of selenite on the chimeric receptor were blocked by the antiestrogen, suggesting that selenite activates ER-alpha through an interaction with the hormone binding domain of the receptor. Transfection assays with ER-alpha mutants identified C381, C447, H524, and N532 as interaction sites of selenite with the hormone binding domain.

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“…For example, it has been shown that although no significant modification was found in hair Cu levels adjusted for the main confounders, plasma Cu was increased in lung cancer patients compared to controls [19]. In the other study, no difference between breast cancer cases and controls was detected in both hair and plasma level of Cu.…”

Section: Discussionmentioning

confidence: 81%

Comparative quantative analysis of zinc, magnesium, and copper content in the scalp hair of healthy people and breast cancer patients

Kilic

Demiroglu

Saraymen

et al. 2004

J Trace Elements Exper Med

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A quantitative elemental analysis of scalp hair of female breast cancer patients (n = 26) and female controls (n = 27) was used to study to find out correlation and possible changes, between breast cancer and healthy controls. Atomic absorption spectrophotometer analysis of the quantitative method was used to determine copper, magnesium, and zinc levels. There were no differences in magnesium concentrations (P > 0.05) in breast cancer patients and healthy subjects. However, comparison of mean elemental contents of the breast cancer patients with controls showed a significant enhancement of copper (P < 0.05) but declining trends for zinc (P < 0.05) in breast cancer patients. The usefulness and significance of element status in cancer patients should be discussed more detailed in the light of the most these recent data.

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Observations on the Use of Plasma, Hair and Tissue to Evaluate Trace Element Status in Cancer

Cited by 45 publications

References 16 publications

Micronutrients, antioxidants, and carcinoma of the gallbladder

Micronutrients, antioxidants, and carcinoma of the gallbladder

Effects of selenite on estrogen receptor-? expression and activity in MCF-7 breast cancer cells

Comparative quantative analysis of zinc, magnesium, and copper content in the scalp hair of healthy people and breast cancer patients

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