Observations on the Ureteropelvic Junction

Foote, John; Blennerhassett, John B.; Wiglesworth, F. W.; Mackinnon, Kenneth J.

doi:10.1016/s0022-5347(17)61710-5

Cited by 67 publications

(17 citation statements)

References 12 publications

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“…Other limitations were the lack of grading the pathologic features [24]. One study observed findings similar to our results with muscular hypertrophy in two-thirds and muscle atrophy in one-third of all cases [22].…”

Section: Discussionsupporting

confidence: 77%

“…Surprisingly, in our reviewed CV specimens, we did not find any lower scores for the so-called intrinsic alterations such as muscular hypertrophy, fibrosis, and chronic inflammation. Only few other reports compared histomorphological aspects of ureteral segments in IUPJO with those of CV patients [22][23][24][25]. In most of them, significant differences between IUPJO and CV specimens have been described with fewer or even no intrinsic alterations of the ureteral wall in CV patients [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differences between intrinsic and extrinsic ureteropelvic junction obstruction related to crossing vessels: histology and functional analyses

Ellerkamp¹,

Kurth²,

Schmid³

et al. 2015

World J Urol

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Differences between intrinsic and extrinsic ureteropelvic junction obstruction related to crossing vessels: histology and functional analyses

Ellerkamp¹,

Kurth²,

Schmid³

et al. 2015

World J Urol

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“…This observation raises the question of an adynamic segment creating an "obstruction." Early studies of the UPJ have shown abnormal configurations of muscle bundles and also decreased quantity of musculature [4,7,8]. Electron microscopy has revealed disruption of the intercellular relationship between muscle bundles of the UPJ [4,9].…”

Section: Etiologymentioning

confidence: 99%

Pathophysiology and treatment of ureteropelvic junction obstruction

Williams¹,

Tareen²,

Resnick

2007

Curr Urol Rep

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This paper reviews the current literature on both the pathophysiology and treatment options for ureteropelvic junction obstruction (UPJO). A medical literature search using Pubmed/Medline that addressed both the pathophysiology of UPJO and the different treatment options for the adult and pediatric population with UPJO was performed. The pathophysiology of UPJO is still unknown but appears to be multifactorial. Perhaps future molecular studies will give us an answer to the etiology and also a pathway in preventing UPJO. Treatment options have been studied in-depth, and the gold standard is open pyeloplasty. In both the pediatric and adult population, laparoscopic or robotic pyeloplasty has similar success rates to open pyeloplasty with the benefits of minimally invasive surgery. In the pediatric population, however, further studies need to be done. Endopyelotomy also has a role in the treatment of UPJO but should have strict selection criteria.

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“…Nonsignificant changes were always observed in the poststenotic segment [6][7][8]. Cell disarrangement and smooth muscle hypotrophy tissue in the stenotic UPJ segments of obstructed UPJ have already been reported [5][6][7]9,10,12].…”

Section: Discussionmentioning

confidence: 82%