Observations on the Radiation Decomposition of Some C¹⁴-Labeled Compounds¹

Abstract

Varying amounts of radiation decomposition during storage i n the dry form have been found in the cases of ~k l a b e l e d valine, norvaline, norlewine, choline chloride, calcium glycolate and cholesterol, These data indicate t h a t investigators using labeled organic compounds should make frequent checks of the purity of these compoun8.s i n order t o exclude

Stability and storage of compounds labelled with radioisotopes

“…ROCHLIN(") has adequately reviewed the published information up to April 1965 concerning the decomposition of carbon-14 compounds, which includes a detailed summary of the early work of TOLBERT et al (3). It would be superfluous to re-summarise this information for the present review and instead some results obtained at the Radiochemical Centre for a wide variety of compounds are listed in Table 6.…”

“…excluding the paper from the 'system'. ** = Calculated from the equation [3]. ' = Solutions sterilised by autoclaving at 120 for 30 minutes.…”

Methodology and validation of a new tandem mass spectrometer method for the quantification of inorganic and organic 18O-phosphate species

“…Consequently, the half-lives of a radionucleotide is 5-20 times shorter than the radioisotope as the radionucleotides self-destructs [18]. Interactions with released energy or with any radiation-produced reactants (i.e., radicals) from labelled molecules causes damage to nearby biomolecules and nucleic acids [19]. Additionally, the half-lives of 32 P and 33 P (14.3 days and 24.4 days) restrict the length of studies due to self-radiolysis [4,18].…”

Radiochemical stability of 14C‐compounds on storage: benefits of thioethers

“…2 Due to internal irradiation, decomposition of labelled compounds occurs much faster than for the non-labelled compound and so frequent re-purification and re-analysis is required. 3 These time-consuming procedures can be reduced by suitable storage. In the present paper, the results of storage as a neat solid or oil, at several temperatures, are compared with those using various solutions at À208C.…”