Observations on the Kinetics of Transfer of Xenon and Chloroform Between Blood and Brain in the Dog

A Study of the Arterial Clearance of Xenon 133 in Man

“…It has been stated previously that "xenon is almost completely cleared from the bloodstream in a single passage through the pulmonary circu-lation so that during the clearance phase it is possible to neglect the arterial concentration" (Veall and Vetter, 1958). This statement was based on work in dogs in which the arterial concentrations of xenon 133 were estimated after inhalation of the gas (Pittinger et al, 1956). These authors stated that "something of the order of 95 per cent of the xenon .…”

Vital issues in computing decompression schedules from fundamentals

“…about 10 rain by Kety and Schmidt (1945) for N20 in brain, about 5 min by Ing~car and Lassen (1962) for Kr in cerebral cortex, about 14 min by Lassen and Munck (1954} for Kr in brain, about 6 rain by Pittinger et al (1956) for xenon in brain, about 5 min by Pittinger et al (1956) for CC14 in brain. about 10 rain by Kety and Schmidt (1945) for N20 in brain, about 5 min by Ing~car and Lassen (1962) for Kr in cerebral cortex, about 14 min by Lassen and Munck (1954} for Kr in brain, about 6 rain by Pittinger et al (1956) for xenon in brain, about 5 min by Pittinger et al (1956) for CC14 in brain.…”

Pathologic Changes Following Chronic Exposures to Halothane: A Review

“…Various investigators (20, 86, 87) also indicated that acute exposure to subanesthetic concentrations of anesthetics produces temporary deficits in a variety of human behavioral function, including memory, mood, and psychomotor impairment. Due to its small molecular size and high lipid solubility, halothane as well as other anesthetics, readily transfers across the blood-brain barrier (88). An autoradiographic study (89) indicated that halothane is distributed to the cerebral cortical gray matter rapidly during exposure.…”