A Study of the Arterial Clearance of Xenon 133 in Man

Isbister, William H.; Schofield, Philip F.; Torrance, H B

doi:10.1093/bja/37.3.153

Cited by 11 publications

(3 citation statements)

References 1 publication

(1 reference statement)

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“…In contrast to the injection technique, in which this factor is minimal, an adequate correction for recirculation is necessary in the present method (27). Its influence is apparent from the shape of the head curves (Figs.…”

Section: Obrist Thompson King Wangmentioning

confidence: 94%

Determination of Regional Cerebral Blood Flow by Inhalation of 133-Xenon

Obrist

Thompson

King

et al. 1967

Circulation Research

370

113

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A method for estimating regional cerebral blood flow is described in which tracer amounts of 138 Xe are inhaled for 2 min and monitored extracranially over the next 45 to 60 min. A three-compartment model used to analyze the resulting clearance curves provided separate blood flows for "gray" and "white" matter, plus a decay constant for a slow third component, believed to arise from extracerebral tissue. The analysis included a correction for recirculation of all three components, based on radioisotope concentration of the expired air or arterial blood. Results from the analysis were compared with those obtained by the more traditional two-compartment approach, using data from 15 healthy young males. Whereas the three-compartment method yielded measurements comparable with those obtained by established techniques (average CBF = 54.7 ml/100 g/min), the two-compartment analysis gave consistently lower values (average CBF = 30.2). Comparison of results based on expired air and arterial sampling suggested that end-expiratory air is a reasonable substitute for arterial blood. Although the I3S Xe inhalation method is technically simpler and less traumatic than other methods, complex analytic treatment of the data is necessitated by the presence of appreciable recirculation and extracerebral contamination. • In 1963 Lassen and co-workers (1) introduced a method for measuring regional cerebral blood flow in man that has yielded results (2, 3) consistent with older established techniques. This method involves the extracranial monitoring of an inert, diffusible radioisotope (85-krypton or 133-xenon) injected into the internal carotid artery. The clearance curves so obtained are subjected to a twocompartment analysis (4, 5) in which separate

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Section: Obrist Thompson King Wangmentioning

confidence: 94%

Determination of Regional Cerebral Blood Flow by Inhalation of 133-Xenon

Obrist

Thompson

King

et al. 1967

Circulation Research

370

113

View full text Add to dashboard Cite

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“…18 A correction for recirculation is possible, however, from knowledge of the arterial input, obtained by monitoring isotope concentration in the blood or end-tidal air.…”

Section: Theoretical Modelmentioning

confidence: 99%

Regional Cerebral Blood Flow Estimated by ¹³³ Xenon Inhalation

Obrist

Thompson

Wang

et al. 1975

Stroke

883

228

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Abstract:Regional Cerebral Blood Flow Estimated by ™Xenon Inhalation • A method is described for estimating the clearance rate and fractional blood flow of the fast (gray matter) compartment of the brain from the first ten minutes of 133 Xe clearance curves, following a one-minute inhalation. Computer-simulated data were used to test the adequacy of the two-compartmental model employed, and to evaluate the stability of the parameters in the presence of random noise. A comparison was made between this approach and the previously reported three-compartmental analysis. Regional cerebral blood flow data were obtained on 48 young control subjects and 20 elderly demented patients. Hemispheral, regional, and test-retest variations were determined, as well as differences between the groups.

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“…This rapid rise indicates that, except for about the first 2 minutes of intake of xenon, the inspired concentration is a good reflection of alveolar concentration. However, there is reason to believe that this alveolar xenon concentration is not completely reflective of that in arterial blood (Isbister, Schofield and Torrance, 1965). Because of ventilation-perfusion variations present even in normal lungs, alveolar and arterial values for xenon may be significantly different (arterial Xe partial pressure/end-tidal Xe partial pressure <0.95) for the first 5 to 15 minutes of xenon inhalation.…”

Section: Methodsmentioning

confidence: 99%

Rate of Rise of Alveolar Xenon Concentration in Man

Gregory¹,

Shargel²,

Eger³

et al. 1966

British Journal of Anaesthesia

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The rate of rise of alveolar xenon concentration toward a fixed inspired level was measured in four adult male volunteers. At 1 minute the ratio of end-tidal to inspired xenon concentration was 0.76, at 2 minutes it was 0.38, at 5 minutes it was 0.96, and at 20 minutes it was 0.97. These results agree with those predicted from xenon solubility in blood and tissues, and were closely simulated with a passive resistancecapacitor analogue.

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A Study of the Arterial Clearance of Xenon 133 in Man

Cited by 11 publications

References 1 publication

Determination of Regional Cerebral Blood Flow by Inhalation of 133-Xenon

Determination of Regional Cerebral Blood Flow by Inhalation of 133-Xenon

Regional Cerebral Blood Flow Estimated by ¹³³ Xenon Inhalation

Rate of Rise of Alveolar Xenon Concentration in Man

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A Study of the Arterial Clearance of Xenon 133 in Man

Cited by 11 publications

References 1 publication

Determination of Regional Cerebral Blood Flow by Inhalation of 133-Xenon

Determination of Regional Cerebral Blood Flow by Inhalation of 133-Xenon

Regional Cerebral Blood Flow Estimated by 133 Xenon Inhalation

Rate of Rise of Alveolar Xenon Concentration in Man

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Regional Cerebral Blood Flow Estimated by ¹³³ Xenon Inhalation