“…">Those found in sites reported to have a relatively high treatment failure rate, namely, the periorbital area, nasolabial fold, nose‐cheek angle, posterior ear sulcus, pinna, canal of the ear, and forehead, and those in scar tissue 2,21,36,58,63–66 - Those with poorly delineated clinical borders 37
- Those that are very large (greater than 2 cm) 19
- Those with aggressive, infiltrative features, as denoted by history and physical examination 2,29
- Those with histopathologic features portraying aggressive behavior: morpheaform or sclerotic, multicentric, infiltrating, or basosquamous forms of basal‐cell carcinomas 19,29,37,67,68
- Those in areas where maximal preservation of uninvolved tissues is desirable, e.g., eyelid, nose, finger, penis 7
- Squamous‐cell carcinoma with perineural invasion 25
…”