1981
DOI: 10.1111/j.1524-4725.1981.tb00662.x
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Morpheaform Basal‐Cell Epitheliomas

Abstract: A series of morpheaform basal‐cell epitheliomas was studied to determine their subclinical extensions beyond poorly delineated clinical borders. Findings and recommendations for therapy are discussed.

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Cited by 159 publications
(11 citation statements)
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References 30 publications
(63 reference statements)
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“…The aggressive subtypes are frequently more ill-defined clinically with less predictable radial growth patterns leading to greater subclinical extension of tumor. When viewed by traditional “bread loaf” processing of permanent sections after standard or staged excisions, these areas of tumor extension can be missed, leading to a false-negative result [ 17 ].…”
Section: Clinical Features and Diagnosismentioning
confidence: 99%
“…The aggressive subtypes are frequently more ill-defined clinically with less predictable radial growth patterns leading to greater subclinical extension of tumor. When viewed by traditional “bread loaf” processing of permanent sections after standard or staged excisions, these areas of tumor extension can be missed, leading to a false-negative result [ 17 ].…”
Section: Clinical Features and Diagnosismentioning
confidence: 99%
“…Although there was a large difference between normal skin and basal cell carcinomas in enzyme/inhibitor profile, we were unable to clearly distinguish tumours defined as aggressive growth pattern basal cell carcinoma from tumours with less aggressive growth patterns on the basis of enzyme/inhibitor profile. Clinical studies have demonstrated that tumours identified as aggressive growth pattern types tend to invade more deeply, and have a higher recurrence rate (perhaps not surprisingly) than nodular or superficial basal cell tumours (Salasche and Amonette, 1981;Lang and Maize, 1986). Additionally, the more aggressive tumours tend to be surrounded by a discontinuous basement membrane, in contrast to nodular or superficial types of basal cell carcinomas, which often have an intact basement membrane (Johnson et al, 1993).…”
Section: -mentioning
confidence: 99%
“…Those with histopathologic features portraying aggressive behavior: morpheaform or sclerotic, multicentric, infiltrating, or basosquamous forms of basal‐cell carcinomas 19,29,37,67,68 …”
Section: Discussionmentioning
confidence: 99%