Observations on Rats with a Transplantable Fibrosarcoma Treated with Cevitamic (Ascorbic) Acid

Pollia, Joseph A.

doi:10.1148/25.3.338

Cited by 3 publications

(2 citation statements)

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“…Except for some earlier reports (Watson, 1936;Robertson, Dalton and Heston, 1949;Russell, Ortega and Wynne, 1952) on guinea-pigs, most of the reports in the literature refer to experiments in which mice and rats were used (Pollia, 1935;Woodhouse, 1934;Brunschwig, 1943).…”

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confidence: 99%

Effect of ascorbic acid on tumour growth

Migliozzi¹

1977

Br J Cancer

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Summary.-The growth of tumours in guinea-pigs was observed for 20 weeks after placing them on various doses of vitamin C.Complete tumour regression occurred in 55% of those animals receiving 0-3 mg/kg/day ascorbic acid, whereas animals given 10 mg/kg/day showed tumour inhibition but no regression. In contrast, tumours in animals maintained on 1 g/kg/day ascorbic acid grew without sign of retardation. When increased amounts of ascorbic acid were restored to the diet of scorbutic tumour-bearing animals, tumours which had not regressed responded with enhanced growth. Likewise, animals previously maintained on 10 mg/kg ascorbic acid responded in turn to the additional vitamin with enhanced tumour growth. In contrast, all tumour-bearing animals maintained on 1 g/kg ascorbic acid died within 3 weeks when this dose was replaced with 0-3 mg/kg.

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confidence: 99%

Effect of ascorbic acid on tumour growth

Migliozzi¹

1977

Br J Cancer

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“…Vitamins are important for the growth of both human and animal tissues. Fodor and Kunos 8 reported that subcutaneous injection of vitamin C in tumor mice resulted in a great increase in the size, whereas Pollia 9 apparently did not observe a similar effect on the growth in vivo of a malignant dibenzanthracene tumor of the rat.…”

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confidence: 99%