Observations on Radiothyroidectomized Chickens

In vitro Thymidine Uptake and Incorporation into Thymic and Bursal Lymphocytes from Young Hypothyroidic Chickens

“…The reductions of body weights and relative weights of lymphoid organs, as observed in the pres ent study, have been reported previously for hypothy roid chickens [1,3,5,6,[10][11][12], Kai et al [5] reported severe atrophy of the thymus and bursa characterized by reduced lymphocyte number in both organs and deposition of connective tissue in the bursal follicles. Histological observations of thymus and bursa sec tions from chicks in this study revealed a similar situ ation.…”

Effect of Embryonic Administration of 131I Upon Reproductive Performance of the White Leghorn

“…Symptoms of hypothyroidism were readily apparent in birds that received 25 or 50 [iCi. 131 I at 16 days of incubation as described by Blivaiss (1947) in surgically thyroidectomized chickens and by Winchester et al (1949); Mellen and Wentworth (1962), and Seigel and Mraz (1965) in "radiothyroid-ecrecticized" ones. Smaller thyroids were observed in 6-week-old birds that received 5 or more |JiCi.…”

“…The use of a low iodine diet plus thiouracil reduced the 131 I necessary for thyroid destruction to 1500 jJiCi. per 100 g. (Mellen and Wentworth, 1962). However, Seigel and Mraz (1965) reported that 5 [/.Ci.…”

Radioisotopes and Poultry

“…Chick thyroids were destroyed with an intraperitoneal injection of approximately 1-5 mc carrier-free 1131 per 100 grams of body weight following pretreatment with a low-iodine diet and thiouracil (87). In spite of failure to demonstrate residual thyroid tissue in most of these chickens, thyronine and triiodothyronine were found in blood plasma when apparently thyroidless birds were injected with 1131 several months after radio-thyroid-ecrexis.…”