Observations on gastric acidity before and after development of carcinoma of the stomach

Comfort, Mandred W.; Butsch, Winfield L.; Eusterman, George B.

doi:10.1007/bf03000431

Cited by 16 publications

(10 citation statements)

References 21 publications

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“…However, it is also possible that this is partly a cohort effect. Environmental factors more prevalent in previous years may have increased the development of atrophic gastritis in those alive at that time. Era: Within the western population, there is evidence that the prevalence of atrophic gastritis in the H. pylori ‐infected population was higher in previous than in current generations 24–27 . This might be explained by environmental factors, such as greater dietary intake of salt, and lower dietary intake of antioxidants in these earlier times. Host genetics: Polymorphisms of the genes coding the various cytokines involved in the inflammatory response to H. pylori infection have been shown to influence the pattern of gastritis and acid secretion 28 .…”

Section: Mechanism Of Interaction Between H Pylori and Gerd – The Romentioning

confidence: 99%

“…Era: Within the western population, there is evidence that the prevalence of atrophic gastritis in the H. pylori ‐infected population was higher in previous than in current generations 24–27 . This might be explained by environmental factors, such as greater dietary intake of salt, and lower dietary intake of antioxidants in these earlier times.…”

Section: Mechanism Of Interaction Between H Pylori and Gerd – The Romentioning

confidence: 99%

“…The effects of H. pylori infection and acid secretion may also explain the changes in prevalence of reflux disease and its complications over recent decades 34–39 . In the past, H. pylori infection had a greater propensity to induce atrophic gastritis and low acid secretion, which may have protected the population from reflux disease 24–27 . As the infection and its suppressing effects on acid secretion become smaller, then the protection will be lost and the incidence of reflux disease and its complications rise.…”

Section: Implications Of Pattern Of H Pylori Gastritismentioning

confidence: 99%

“…[34][35][36][37][38][39] In the past, H. pylori infection had a greater propensity to induce atrophic gastritis and low acid secretion, which may have protected the population from reflux disease. [24][25][26][27] As the infection and its suppressing effects on acid secretion become smaller, then the protection will be lost and the incidence of reflux disease and its complications rise.…”

Section: With Respect To Changing Prevalence Of Gerdmentioning

confidence: 99%

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Review article: Helicobacter pylori and gastro‐oesophageal reflux disease

Delaney

McColl

2005

Aliment Pharmacol Ther

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SUMMARYEpidemiological studies demonstrate a negative association between Helicobacter pylori infection and gastrooesophageal reflux disease and its complications. This might represent a protective effect because of the tendency for H. pylori infection to lower gastric acid secretion with advancing age. However, studies of the effect of H. pylori eradication on gastro-oesophageal reflux disease have failed to show any worsening of gastro-oesophageal reflux disease symptoms. Several interactions between H. pylori and proton-pump inhibitor therapy used to treat gastro-oesophageal reflux disease need to be considered. Helicobacter pylori infection improves the control of gastric acidity by proton-pump inhibitors and this produces a small advantage in clinical control of reflux disease. The infection prevents rebound acid hypersecretion occurring when proton-pump inhibitor therapy is discontinued. However, concerns have been expressed that the body gastritis induced by protonpump inhibitor therapy in H. pylori-infected subjects might increase the risk of gastric cancer. At present, it is unclear whether H. pylori should be eradicated in gastrooesophageal reflux disease patients.

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Section: Mechanism Of Interaction Between H Pylori and Gerd – The Romentioning

confidence: 99%

Section: Mechanism Of Interaction Between H Pylori and Gerd – The Romentioning

confidence: 99%

Section: Implications Of Pattern Of H Pylori Gastritismentioning

confidence: 99%

Section: With Respect To Changing Prevalence Of Gerdmentioning

confidence: 99%

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Review article: Helicobacter pylori and gastro‐oesophageal reflux disease

Delaney

McColl

2005

Aliment Pharmacol Ther

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“…Elderly people have physiologically de creased gastric acid secretion due to mucosal atrophy, while decreased acid secretion is also frequently observed in patients with gastric cancer [1][2][3], A relationship between mocosal atrophy and intestinal metaplasia has been recognized according to age, and a relation ship between the intestinal type of gastric can cer and intestinal metaplasia of the stomach has also been reported [4][5][6].…”

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confidence: 99%

Association between Serum Gastrin Levels, Gastric Acid Secretion and Age in Early Gastric Cancer

et al. 1997

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This study evaluated the effect of gastric acid secretion and serum gastrin response on tumor differentiation for early gastric cancer according to patients’ age. We investigated the association between serum gastrin levels, gastric acid secretion and the histologic types of 335 early gastric carcinomas limited to the mucosal and submucosal layers in comparison with 450 gastric and 197 duodenal ulcers. The preoperatively examined basal acid output, maximal acid output and peak acid output after administration of tetragastrin and serum gastrin levels before and after ingestion of a test meal were determined. Patients with differentiated cancer and duodenal ulcer showed a significant negative correlation between gastric acid secretion and age, while the former group also had a significant positive correlation between serum gastrin levels and age. On the other hand, patients with undifferentiated cancer did not show any such correlation between gastric acid and age, but showed a significant positive correlation between serum gastrin, integrated gastrin response and age. Patients with gastric ulcer did not show any such correlations. These data suggest that both low acid secretion and endogenous hypergastrinemia, especially in the elderly, may play an important role in differentiated and undifferentiated gastric carcinomas.

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Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology

Hartman

1982

Chemical Mutagens

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Observations on gastric acidity before and after development of carcinoma of the stomach

Cited by 16 publications

References 21 publications

Review article: Helicobacter pylori and gastro‐oesophageal reflux disease

Review article: Helicobacter pylori and gastro‐oesophageal reflux disease

Association between Serum Gastrin Levels, Gastric Acid Secretion and Age in Early Gastric Cancer

Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology

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