Observations on experimental marginal periodontitis in rats

Kuhr, Alexander; Popa‐Wagner, Aurel; Schmoll, H.-J.; Schwahn, Christian; Kocher, Thomas

doi:10.1111/j.1600-0765.2004.00710.x

Cited by 86 publications

(97 citation statements)

References 28 publications

(45 reference statements)

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“…Various experimental periodontitis models have been proposed in the extant literature (27)(28)(29)47). Ligatures placed in the dentogingival area increase plaque formation and the amount of bacteria, and induce effective plaque-host interactions (43,48).…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties.Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

“…Ligatures (Silk suture 3/0, Doğsan, Istanbul, Turkey) were placed at the gingival margin of the second molars (28)(29)(30)(31), and melatonin was administered intraperitoneally (i.p.) at a dose of 10 mg/kg (dissolved in ethanol/saline solution 1%, MerckSchuchardt, Hohenbrunn, Germany) per day for 2 weeks (32).…”

Section: Experimental Designmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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“…These authors reported that the substantial alveolar bone loss originated on day 3 of periodontitis induction reached a maximum between days 7 and 11. In line with this data, Kuhr et al 24 revealed that the application of this model of periodontitis induction can only be recommended for short periods (less than 15 days). According to these authors, who evaluated the periodontal destruction following experimentally induced periodontitis in rats over a 60-day observation period, it was demonstrated that the ligatureinduced bone loss increased most from day 1 to day 15, whereas on days 30 and 60 slighter increases in bone loss were observed, supporting the period of periodontitis induction used in the present study.…”

Section: Discussionmentioning

confidence: 80%

Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats

et al. 2012

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Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats Abstract: The aim of this study was to evaluate the effect of an organic extract obtained from Ipomoea alba L. (Convolvulaceae or OE 1493), on experimental periodontal disease in rats. Periodontitis was induced in thirty six Wistar rats: a first mandibular molar was randomly assigned to receive a ligature, whereas the contralateral molar was left unligated. Animals were randomly assigned to two groups and treated topically, three times a day, for 11 days, as follows: Control Group -vehicle-treated (n = 18), and Test Group -OE 1493-treated (n = 18). The rats were sacrificed on the 12 th day. Morphometrical measurements from the cementoenamel junction to the bone crest were performed to determine alveolar bone loss, using standardized photographs. Single-and multi-dose acute toxicity assays were carried out after OE 1493 treatment. Morphometrical analysis demonstrated that topically-administered OE 1493 showed no effect on reducing bone loss when compared with the control group (p > 0.05). In addition, OE 1493 did not present toxicity. Within the limits of this investigation, it may be concluded that OE 1493 did not show any positive influence on the progression of ligature-induced periodontitis in rats, when administered according to the regimen used in the present study.

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“…The current periodontal disease classification lists "diabetes mellitus-associated gingivitis" as a distinct disease entity, although there is no distinct diabetes-associated periodontitis, uncontrolled or poorly controlled DM is considered a modifier of preexisting periodontitis that adjunctively enhances its severity (13) .…”

Section: Discussionmentioning

confidence: 99%

Effect of Topically- Applied Hyaluronan on the Expression of Prolyl 4- Hydroxylase in Gingivitis of Diabetic Rats

Nahla

Sheikh²,

Gawish³

2017

ADJ-for Girls

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Objective:To evaluate the effect of topically applied hyaluronic acid gel (hyaluranon) on gingivitis in diabetic rats. The evaluation based on clinical, histological, and immunohistochemical analysis. Materials and Methods:The present study included seventy rats were included in this study, sixty rats were divided into two main groups according to treatment modality, group I involved thirty rats treated with topical HA, while group II involved thirty rats left untreated. Furthermore groups I and II subdivided into subgroups Ia, IIa were sacrificed on the seventh day, and subgroups Ib, IIb were sacrificed was sacrificed on the day fourteen, negative control compromised five healthy rats, and positive control group compromised five diabetic rats. Harvested gingival specimens were fixed in formalin, then embedded in paraffin wax, and serially sectioned at 4µm for immunohistochemical assessment using Prolyl 4 Hydroxylase A1(P4HA1). Results: Immunohistochemical evaluation using P4HA1 revealed a significant difference between all groups.

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Observations on experimental marginal periodontitis in rats

Abstract: The application of this model can only be recommended for short (

Cited by 86 publications

References 28 publications

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats

Effect of Topically- Applied Hyaluronan on the Expression of Prolyl 4- Hydroxylase in Gingivitis of Diabetic Rats

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