Observations on Ctab (Cetavlon) Its Use in Surgery

Williams, R. E. O.; Clayton-Cooper, Barbara; Duncan, Julie; Miles, EllenM.

doi:10.1016/s0140-6736(00)43081-3

Cited by 20 publications

(7 citation statements)

References 9 publications

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“…The fact that the potency of CTAB is reduced by organic matter has also been noted by Williams, Clayton-Cooper, Duncan & Miles (1943), who observed that the presence of 10% horse serum caused a' 27-fold drop in its effective concentration.…”

Section: Effect Of Organic Matter On Disinfectantsmentioning

confidence: 57%

Thein vitroaction of disinfectants and the application of CTAB in the control ofStr. agalactiaemastitis

Hughes

Edwards

1946

Epidemiol. Infect.

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TECHNIQUE EMPLOYED FOR COMPARING THE IN VITRO POTENCY OF DISINFECTANTSThe technique involved in comparing the various disinfectants was to test their efficiency at varying dilutions against calculated numbers of Str. agalactiae at room temperature (18°C.). At intervals one drop (0-02 ml.) of each concentration was removed, as in the Rideal-Walker test, but instead of subculturing into broth, the number of viable organisms in the drop was determined by roll-tube counts (Wilson, 1922), using blood agar as the culture medium. The test was carried out in duplicate.This method of evaluating the 'end-point' of each disinfectant was chosen because a better appreciation could be made of the death-rate by a quantitative method than by subculturing in broth.In deciding the time during which the organism was in contact with the disinfectant dilution, a maximum period of 4 min. was allowed, since in routine dairy practice it would not be convenient to permit a longer time for contact with hands, utensils, etc. In quoting effective concentrations of disinfectants, certain authors have given results based on the reaction between the test organism and disinfectant after 18 hr. at 370 C., an interval which would not be applicable in practice. The medium used for conducting the test and making the dilutions of disinfectant was sterile tap water. RESULTSThe results of a preliminary test are shown in Table 1.It may be seen that in the case of Chloros, Milton, Deosan and CTAB, no end-point was observed -in the range of dilutions chosen, since all were bactericidal. An interesting comparison, however, may be made between the last three substances. After

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Section: Effect Of Organic Matter On Disinfectantsmentioning

confidence: 57%

Thein vitroaction of disinfectants and the application of CTAB in the control ofStr. agalactiaemastitis

Hughes

Edwards

1946

Epidemiol. Infect.

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“…He gave 1-g. doses of 2-aminophenol to 6 rabbits of 2.5 kg., apparently without toxic effect. He also showed (Williams, 1943) that 2-and 4-aminophenol glucuronides were methaemoglobin-formers in vitro.…”

Section: Methodsmentioning

confidence: 95%

“…These workers found that this compound, compared with a large number of similar substances, was the most active in inhibiting the oxygen uptake of liver suspensions. Williams (1938Williams ( , 1943 has studied the fate of 2-, 3-, and 4-aminophenol in the body. He has shown that 2-aminophenol when fed to rabbits by stomach-tube is excreted in conjugation with both sulphuric acid and glucuronic acid.…”

Section: Methodsmentioning

confidence: 99%

“…The action of C.T.A.B. has been studied by Barnes (1942) and Williams et al (1943Williams et al ( , 1944, but unfortunately its antibacterial action is drastically reduced by the presence of organic matter. Phemeride has been shown by Iland (1944) to have an antibacterial action stronger than that of C.T.A.B., to be effective in the presence of 50% blood, and to be relatively non-toxic to the tissues of the body.…”

Section: Antibacterial Action Of 2-aminophenolmentioning

confidence: 99%

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Antibacterial Action of 2-Aminophenol

Barber¹,

Haslewood²

1944

BMJ

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“…They considered that for handkerchiefs C.P.B. was unsuitable, as it had been reported by Williams, Clayton-Cooper, Duncan, and Miles-(1943) that some people (under 1%) are sensitive to its local application. Vaughan, Sotier, Hill, Simpson, and Lee (1948) examined ways to sterilize woollens in a laundry wash process.…”

Section: Sterilization Of Blanketsmentioning

confidence: 99%

Sterilization of Woollen Fabrics

Barnard¹

1952

BMJ

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Observations on Ctab (Cetavlon) Its Use in Surgery

Cited by 20 publications

References 9 publications

Thein vitroaction of disinfectants and the application of CTAB in the control ofStr. agalactiaemastitis

Thein vitroaction of disinfectants and the application of CTAB in the control ofStr. agalactiaemastitis

Antibacterial Action of 2-Aminophenol

Sterilization of Woollen Fabrics

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