Observations on Chronic Polyarthritis in Monkeys

Bywaters, E. G. L.

doi:10.1177/014107688107401104

Cited by 15 publications

(3 citation statements)

References 8 publications

(6 reference statements)

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“…This distribution pattern, sparing the small joints of the hands, occurs in spondyloarthropathy (Resnick and Niwayama, 1988;Rothschild, 1982;Rothschild and Woods, 1989). Asymmetrical erosive arthritis and proximal interphalangeal and metacarpal phalangeal joint marginal erosions with ankylosis have been reported in Macaca mulatta (Bywaters, 1981;Obeck et al, 1976). These patterns are also highly suggestive of spondyloarthropathy (Resnick and Niwayama, 1988;Rothschild, 1982;Rothschild and Woods, 1989).…”

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Erosive arthritis and spondyloarthropathy in old world primates

Rothschild

Woods

1992

American J Phys Anthropol

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Presence of spine and sacroiliac involvement and the nature and distribution of the erosive lesions allow definitive diagnosis of spondyloarthropathy. Thus, spondyloarthropathy was identified in Theropithecus, Papio, Cercopithecus, Macaca, Colobus, Presbytis, and Hylobates. Only monarticular erosive disease was present in prosimians, precluding a diagnosis of spondyloarthropathy for that group. The distribution of erosive disease and axial joint involvement in 1,349 non-prosimian Old World primates is quite characteristic of that noted in human psoriatic arthritis. While Reiter's syndrome must also be considered, the histologic appearance of skin lesions in Macaca is characteristic of psoriasis. Evidence of spondyloarthropathy abounds in the literature of primate skeletal disease. Environmentally based contagions may be important in the pathophysiology of spondyloarthropathy. The wide geographic distribution of the phenomena in monkeys suggests a "panendemic," with limited individual susceptibility (compared to that noted in gorillas and chimpanzees). Identical occurrence of erosive arthritis/spondyloarthropathy in free-ranging and artificially restrained animals suggests that spondyloarthropathy can validly be studied in artificially restrained populations. This perspective should allow application of human therapeutic approaches to and perhaps improve the quality of life for artificially restrained, afflicted individuals.

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confidence: 94%

“…"Articular changes" and "arthritis deformans" have been reported in Dynastic Egyptian and contemporary monkeys (Bramblett, 1968;Bywaters, 1981;Driesch, 1985;Ford et al, 1986;Fox, 1939). Did these animals actually have spondyloarthropathy?…”

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confidence: 99%

Erosive arthritis and spondyloarthropathy in old world primates

Rothschild

Woods

1992

American J Phys Anthropol

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“…A non-bacterial rodent model is * To whom offprint requests should be sent repesented by collagen-induced arthritis (CIA). The natural occurrence of arthritis in non-human primates has been described in the gorilla [14] and in rhesus monkeys [15][16][17]. Thus, the immune response to collagen may be an event of general importance in the pathogenesis of human RA.…”

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confidence: 99%

Experimental immune mediated arthritis in rhesus monkeys

Bakker

Erck

Zürcher³

et al. 1990

Rheumatol Int

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The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen induced clinical arthritis in 50% of the rhesus monkeys. Type II collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histological, genetic, and immunologic features associated with human RA.

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Systemic lupus erythematosus in a rhesus macaque

Anderson

Klein

1993

Arthritis & Rheumatism

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We describe the clinical course and histopathologic findings in a rhesus macaque (Mucucu mulafta) which developed a systemic inflammatory disorder resembling systemic lupus erythematosus (SLE). The manifestations of the SLE included antinuclear antibody, hemolytic anemia, membranoproliferative glomerulonephritis, and arthritis. To our knowledge, spontaneously occurring SLE has not previously been described in nonhuman primates.

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Observations on Chronic Polyarthritis in Monkeys

Cited by 15 publications

References 8 publications

Erosive arthritis and spondyloarthropathy in old world primates

Erosive arthritis and spondyloarthropathy in old world primates

Experimental immune mediated arthritis in rhesus monkeys

Systemic lupus erythematosus in a rhesus macaque

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