Systemic lupus erythematosus in a rhesus macaque

Anderson, Steven E.; Klein, Edwin

doi:10.1002/art.1780361214

Cited by 10 publications

(3 citation statements)

References 11 publications

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“…This case's histologic lesions bear resemblance to those of cutaneous lupus erythematosus. While systemic lupus erythematosus has previously been identified in macaques , lupus with a purely cutaneous manifestation has not been reported. However, lupus often presents as a primarily dermatologic condition in other species and is associated with acquired palmoplantar keratoderma as seen in this case.…”

Section: Discussionmentioning

confidence: 99%

Immune‐mediated interface dermatitis in a rhesus macaque

Makaron

Smith

Bailey

et al. 2012

J of Medical Primatology

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Section: Discussionmentioning

confidence: 99%

Immune‐mediated interface dermatitis in a rhesus macaque

Makaron

Smith

Bailey

et al. 2012

J of Medical Primatology

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“…Although the discussion to this point has focused on SLE in mice and humans, spontaneous disease is recognized in other species, including rats, cats, dogs, rabbits, guinea pigs, pigs, hamsters, Aleutian minks, horses, and primates. 1,2,40,41,47,58,75,110,124 Of these species, the disease has been most carefully characterized in the dog. Below we describe the characteristics of SLE in several domestic species and discuss the practical limitations of using larger animal models in SLE research.…”

Section: Sle In Other Speciesmentioning

confidence: 99%

“…Spontaneous SLE rarely occurs in nonhuman primates and is characterized by the presence of antinuclear antibodies, hemolytic anemia, membranoproliferative glomerulonephritis, and arthritis. 2 Also, an SLE-like disease can be induced in nonhuman primates by feeding the animals alfalfa seeds or L-canavanine sulfate, a constituent of alfalfa sprouts. 79 SLE has been recognized as a spontaneous disease in cats, characterized by glomerulonephritis (45%), neurologic symptoms (41%), arthritis (41%), anemia (36%), and dermatologic disease (32%).…”

Section: Sle In Other Speciesmentioning

confidence: 99%

Mouse Models of Systemic Lupus Erythematosus Reveal a Complex Pathogenesis

Rottman

Willis

2010

Vet Pathol

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The mammalian immune system is remarkable in that it can respond to an essentially infinite number of foreign antigens. The ability to mount a long-lasting (adaptive) immune response against foreign antigen requires the participation of cells selected from an enormously diverse population of B and T cells. Because the B and T cell receptors expressed by these cells are generated at random, a significant percentage of B and T cells are invariably directed against self-antigen. Under normal circumstances, autoreactive B and T cells are eliminated, reprogrammed, or inactivated in the primary and secondary lymphoid organs. Despite these checks and balances, a small but significant number of people and animals still develop autoimmune disease. One such autoimmune disease-systemic lupus erythematosus-is characterized by the loss of B- and T-cell tolerance to self-antigens (principally nuclear), culminating in multisystemic inflammation. Multiple genetic defects, drug exposure, infectious agents, and environmental factors can contribute to the pathogenesis of the disease. Loss of B- and T-cell tolerance precipitates activation of plasmacytoid and myeloid dendritic cells; collectively, these cells cooperate to form a complex positive feedback loop, continually stimulated by the persistence of self-antigen. Novel treatment strategies now focus on specific inhibition of various aspects of the feedback loop. These specific inhibitors have the potential to be more effective and lack the side effects associated with generalized immunosuppression.

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