Observation of Palatal Wound Healing Process Following Various Degrees of Mucoperiosteal and Bone Trauma in a Young Rat Model

Abstract

The accidental injury or surgery on soft and hard palatal tissue has an adverse impact on normal maxillary morphology. To design a single-factor experiment that excludes other interfering factors on maxillary growth, a young rat model was established to simulate the various degrees of palatal trauma. Eight maxillary parameters were measured to evaluate the impact of palatal trauma on maxillary growth. Furthermore, the acellular dermal matrix (ADM) was applied to cure the palatal trauma and alleviate the adverse impact of bone denudation on the maxillary growth. Micro-CT scanning and histology analyses were used. One-way ANOVA with least significant difference (LSD) post-test was used to evaluate the statistical significance. The palatal trauma mainly disturbed the transverse development of the maxilla. ADM promotes mucosa healing, but there is still an inhibitory effect on maxillofacial growth.

Current insights in the preclinical study of palatal wound healing and oronasal fistula after cleft palate repair

“…A study reported the use of collagen membrane to aid the closure of ONF and showed the effectiveness of good results of this surgery in repairing large ONF( Atherton and Boorman, 2016 ). However, it has been reported that it could not promote mucoperiosteum regeneration ( Srivastava et al, 2001 ; Ophof et al, 2004 ; Liu et al, 2023 ).…”

“…In the situation of cleft palate repair, how to avoid poor palatal wound healing was always confusing, and the solutions were limited. Relaxing incision could help decrease the happening of poor palatal wound healing but might lead to further problems like inhibition of the maxillofacial growth ( Becker and Hansson, 2013 ; Ogata et al, 2017 ; Mahajan et al, 2018 ; Liu et al, 2022 ). Thus, figuring out novel therapeutic strategies for preventing poor palatal wound healing and after cleft palate repair should be important in this field, and preclinical studies were essential.…”

Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine

“…Most FGGs are clinically obtained with the periosteum preserved on the donor area. Studies have found that periosteum loss can interfere with wound healing and lead to increased pain in the operative area, and in still-developing jaws, periosteum loss can lead to developmental deformities [ 62 ].…”

Wound Healing Activity of Binahong Leaf Extract Nanogel on Oral Tissues

“…Bone healing process lasts 2-3 mo after tooth extraction and will be visible in the radiograph image if bone remineralization reaches at least 40 percent [5]. Besides, injury in the palatal site is undeniable which can be caused by trauma, defect, or surgical procedures [6,7]. Palatal wound usually heals in 2-3 w and is more likely to develop scar tissue after healing [8].…”