Obliterative bronchiolitis in haematopoietic stem cell transplantation: can it be treated?

Dh, Bryant

doi:10.1183/09031936.05.00146604

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…The result is the large deposition of collagen and granulation tissue in and around the bronchial structures, with the partial or complete small airway obliteration. Clinical data suggest that nonalloimmunologic inflammatory conditions, such as viral infections, recurrent aspiration, and conditioning chemoradiotherapy may also play a role in the pathogenesis of OB after HSC transplantation [84,85]. Bronchiolitis obliterans organizing pneumonia (BOOP) is a disorder involving bronchioles, alveolar ducts, and alveoli, whose lumen becomes filled with buds of granulation tissue, consisting of fibroblasts and an associated matrix of loose connective tissue.…”

Section: Risks and Obstacles To Stem Cells Application In Clinical Prmentioning

confidence: 99%

Stem cells in clinical practice: applications and warnings

Lodi

Iannitti

Palmieri

2011

J Exp Clin Cancer Res

168

113

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Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim is to take a correct view of the available stem cell subtypes and their rational use in the medical area, with a specific focus on their therapeutic benefits and side effects. We have reviewed the main clinical trials dividing them basing on their clinical applications, and taking into account the ethical issue associated with the stem cell therapy.MethodsWe have searched Pubmed/Medline for clinical trials, involving the use of human stem cells, using the key words "stem cells" combined with the key words "transplantation", "pathology", "guidelines", "properties" and "risks". All the relevant clinical trials have been included. The results have been divided into different categories, basing on the way stem cells have been employed in different pathological conditions.

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Section: Risks and Obstacles To Stem Cells Application In Clinical Prmentioning

confidence: 99%

Stem cells in clinical practice: applications and warnings

Lodi

Iannitti

Palmieri

2011

J Exp Clin Cancer Res

168

113

View full text Add to dashboard Cite

show abstract

“…Although non-alloimmune mechanisms (e.g., gastroesophageal reflux, viral and bacterial infection) have been implicated in the development of obliterative bronchiolitis (OB) and its clinical surrogate, BOS, the almost complete restriction of this condition to the setting of solid-organ and hematopoietic stem cell transplantation 6 underscores the central and fundamental importance of alloimmune injury in its pathogenesis. In addition, the striking involvement of the bronchiolar region in the chronic loss of the allograft reinforces the importance, from a mechanistic viewpoint, of alloimmune injury of this region in particular.…”

mentioning

confidence: 99%