Stem cells in clinical practice: applications and warnings

Lodi, Daniele; Iannitti, Tommaso; Palmieri, Beniamino

doi:10.1186/1756-9966-30-9

Cited by 165 publications

(116 citation statements)

References 264 publications

(253 reference statements)

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“…An impressive number of clinical trials and animal studies have already been performed to determine the therapeutic potential of various stem cells models [10,11]. The first isolation of embryonic stem (ES) cells from mouse goes back to 1981 followed by human ES cell isolation and culture in 1998 [12,13].…”

Section: Stem Cells and Purinergic Signalingmentioning

confidence: 99%

Perspectives of purinergic signaling in stem cell differentiation and tissue regeneration

Glaser

Cappellari

Pillat

et al. 2011

Purinergic Signalling

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Replacement of lost or dysfunctional tissues by stem cells has recently raised many investigations on therapeutic applications. Purinergic signaling has been shown to regulate proliferation, differentiation, cell death, and successful engraftment of stem cells originated from diverse origins. Adenosine triphosphate release occurs in a controlled way by exocytosis, transporters, and lysosomes or in large amounts from damaged cells, which is then subsequently degraded into adenosine. Paracrine and autocrine mechanisms induced by immune responses present critical factors for the success of stem cell therapy. While P1 receptors generally exert beneficial effects including anti-inflammatory activity, P2 receptor-mediated actions depend on the subtype of stimulated receptors and localization of tissue repair. Pro-inflammatory actions and excitatory tissue damages mainly result from P2X7 receptor activation, while other purinergic receptor subtypes participate in proliferation and differentiation, thereby providing adequate niches for stem cell engraftment and novel mechanisms for cell therapy and endogenous tissue repair. Therapeutic applications based on regulation of purinergic signaling are foreseen for kidney and heart muscle regeneration, Clara-like cell replacement for pulmonary and bronchial epithelial cells as well as for induction of neurogenesis in case of neurodegenerative diseases.

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Section: Stem Cells and Purinergic Signalingmentioning

confidence: 99%

Perspectives of purinergic signaling in stem cell differentiation and tissue regeneration

Glaser

Cappellari

Pillat

et al. 2011

Purinergic Signalling

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show abstract

“…93 They have self-renewal and plasticity characteristics, plus they have an advantage over embryonic and fetal stem cells by being easy to obtain and culture. In addition, they do not face ethical problems, because it is feasible to obtain them from the same patient.…”

Section: Potential Of Using Adult Stem Cells In the Regeneration Of Cmentioning

confidence: 99%

Corneal endothelium: developmental strategies for regeneration

Zavala

Jaime

Barrientos

et al. 2013

Eye

103

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The main treatment available for restoration of the corneal endothelium is keratoplasty. This procedure is faced with several difficulties, including the shortage of donor tissue, postsurgical complications associated with the use of drugs to prevent immune rejection, and a significant increase in the occurrence of glaucoma. Recently, surgical procedures such as Descemet's stripping endothelial keratoplasty have focused on the transplant of corneal endothelium, yielding better visual results but still facing the need for donor tissue. The emergent strategies in the field of cell biology and tissue cultivation of corneal endothelial cells aim at the production of transplantable endothelial cell sheets. Cell therapy focuses on the culture of corneal endothelial cells retrieved from the donor, in the donor's cornea, followed by transplantation into the recipient. Recently, research has focused on overcoming the challenge of harvesting human corneal endothelial cells and the generation of new biomembranes to be used as cell scaffolds in surgical procedures. The use of corneal endothelial precursors from the peripheral cornea has also demonstrated to be effective and represents a valuable tool for reducing the risk of rejection in allogeneic transplants. Several animal model reports also support the use of adult stem cells as therapy for corneal diseases. Current results represent important progresses in the development of new strategies based on alternative sources of tissue for the treatment of corneal endotheliopathies. Different databases were used to search literature: PubMed, Google Books, MD Consult, Google Scholar, Gene Cards, and NCBI Books. The main search terms used were: 'cornea AND embryology AND transcription factors', 'human endothelial keratoplasty AND risk factors', '(cornea OR corneal) AND (endothelium OR endothelial) AND cell culture', 'mesenchymal stem cells AND cell therapy', 'mesenchymal stem cells AND cornea', and 'stem cells AND (cornea OR corneal) AND (endothelial OR endothelium)'.

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“…A multi-lineage differentiation potential exists in mesenchymal tissues such as bone, cartilage, adipose tissues, tendons, ligaments, and other tissues. Their apparent capacity to grow in culture, their immunosuppressive activity, and their limited immunogenicity might result in great benefits to clinical practice [13,[24][25][26]. MSCs delivered as intra-articular injections for knee OA might help improve tissue health by acting as repair cells or decreasing inflammation.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…Their potential to produce therapeutic effects lies in their capacity to regenerate articular cartilage injuries and relieve symptoms and in their immunomodulatory and antiinflammatory activity, particularly with regard to the secretion of various factors and to direct cell-cell interaction [13,24,27].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Update on biological therapies for knee injuries: osteoarthritis

Pintan

Oliveira

Lenza

et al. 2014

Curr Rev Musculoskelet Med

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Osteoarthritis (OA) is a progressive disease that causes functional impairment of the joints. Chronic forms of knee OA have been increasing worldwide, limiting patients' quality of life. Recent studies have sought to increase effectiveness and quality in the development of new therapies, such as platelet-rich plasma, hyaluronic acid, stem cells, and nuclear factor κB, aimed principally at reducing proinflammatory activity, pain, and degeneration of the knee joints. The goal of this review is to present an update on biological therapies for knee OA and to provide guidance for future OA studies.

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Stem cells in clinical practice: applications and warnings

Cited by 165 publications

References 264 publications

Perspectives of purinergic signaling in stem cell differentiation and tissue regeneration

Perspectives of purinergic signaling in stem cell differentiation and tissue regeneration

Corneal endothelium: developmental strategies for regeneration

Update on biological therapies for knee injuries: osteoarthritis

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