Objective sleep duration is associated with cognitive deficits in primary insomnia: BDNF may play a role

Fan, Teng-Teng; Chen, Wen‐Hao; Shi, Le; Lin, Xiao; Tabarak, Serik; Chen, Sijing; Que, Jian-Yu; Bao, Yanping; Tang, Xiangdong; Shi, Jie; Lü, Lin; Sun, Hongqiang; Liu, Jiajia

doi:10.1093/sleep/zsy192

Cited by 55 publications

(61 citation statements)

References 53 publications

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“…[57][58][59] A recent study in China found that decreased peripheral BDNF might mediate impaired neuropsychological performances (including brief visuospatial memory, spatial span, managing emotions, fluency, and continuous performance) in insomniacs with short sleep duration. 60 Our results indicate that decreased serum BDNF concentration was linked…”

Section: Cid Seems To Be An Organic Conditionmentioning

confidence: 65%

“…Interestingly, both SWM and ORcM are categories of visual memory, and SWM has similar components to the brief visuospatial memory detected in the aforementioned study. 60 GDNF has a potential neuroprotective effect in the adult brain. In the present study, patients with CID had a significant reduction of serum GDNF when compared to healthy controls, and it had no correlation with sleep quality.…”

Section: Gfapmentioning

confidence: 99%

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<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

Zhang¹,

Li²,

Zhang³

et al. 2020

NSS

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The objective of this study was to investigate whether the serum biomarkers S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) change in patients with chronic insomnia disorder (CID), and if this is the case, whether the altered levels of these serum biomarkers are associated with poor sleep quality and cognitive decline in CID. Patients and Methods: Fifty-seven CID outpatients constituted the CID group; thirty healthy controls (HC) were also enrolled. Questionnaires, polysomnography, Chinese-Beijing Version of Montreal Cognitive Assessment (MoCA-C) and Nine Box Maze Test (NBMT) were used to assess their sleep and neuropsychological function. Serum S100B, GFAP, BDNF, and GDNF were evaluated using enzyme-linked immunosorbent assay. Results: The CID group had higher levels of S100B and GFAP and lower levels of BDNF and GDNF than the HC group. Spearman correlation analysis revealed that poor sleep quality, assessed by subjective and objective measures, was positively correlated with S100B level and negatively correlated with BDNF level. GFAP level correlated positively with poor subjective sleep quality. Moreover, S100B and GFAP levels correlated negatively with general cognitive function assessed using MoCA-C. GFAP level correlated positively with poor spatial working memory (SWM) in the NBMT; BDNF level was linked to poor SWM and object recognition memory (ORcM) in the NBMT. However, principal component analysis revealed that serum S100B level was positively linked to the errors in object working memories, BDNF and GDNF concentrations were negatively linked with errors in ORcM, and GFAP concentration was positively correlated with the errors in the SWM and spatial reference memories. Conclusion: Serum S100B, GFAP, BDNF, and GDNF levels were altered in patients with CID, indicating astrocyte damage, and were associated with insomnia severity or/and cognitive dysfunction.

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Section: Cid Seems To Be An Organic Conditionmentioning

confidence: 65%

Section: Gfapmentioning

confidence: 99%

<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

Zhang¹,

Li²,

Zhang³

et al. 2020

NSS

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“…One study conducted in a Chinese population found a lower level of BDNF in patients with clinical insomnia and cognitive impairment. Patients with MDD who had lower BDNF levels in the central nervous system had evidence of neural death and decreased brain volume, which led to cognitive impairment [45,46]. Rahmani and colleagues concluded that insomnia and depression arelinked to the down-regulation of hippocampal BDNF along with disrupted BDNF expression in the prefrontal cortex [47].…”

Section: Discussionmentioning

confidence: 99%

Sleep Disturbance Severity is Associated With Cognitive Impairment in Patients With First-episode, Treatment-naïve Major Depressive Disorders

Cui

Liu

et al. 2020

Preprint

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BackgroundSleep disorders and cognitive impairment are common in patients with major depressive disorder (MDD), though the relationship between the two remains unclear. We investigated this association in first-episode, treatment-naïve patients with MDD.MethodWe analyzed data from 242 patients withMDD. We divided the patients into 2 groups based on sleep disturbance severity and compared the cognitive impairment odds ratios in different domains between the groups.ResultsA total of 121 pairs of patients were matched (age39.4±10.1, 70.2% female). After propensity score matching, the odds ratios for cognitive impairment in patients with MDD and serious sleep disorders were 1.922 (1.068–3.459, P= 0.029) in executive functioning; 2.023 (1.211–3.379, P= 0.007) in executive shifting; 1.749 (1.000–3.060, P = 0.050) in executive inhibition; and 1.813 (1.038–3.167, P = 0.037) in information processing speed.LimitationsThe cross-sectional data on the relationship between sleep disorders and cognitive impairment were weak. Our study population was restricted to Chinese adults aged 18 to 65 years, so the results may not be generalizable to other populations.Because our sample size was limited, some variables were not included in the study.ConclusionsSleep disturbance is associated with cognitive impairment in the domains of executive functioning and information processing speed in first-episode, treatment-naïve patients with MDD. Sleep problems can be important symptoms for physicians in clinical practice and can aid in recognizing cognitive impairment in patients with MDD. Further study is required to confirm our results.Trial registrationClinicalTrials.gov: NCT02023567; registration date: December 2013.

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“…Sleep duration is strongly correlated with severity of insomnia (Fan et al, 2018). Nocturnal sleep duration was assessed by adapting the item designed by Liu et al (2000): 'How many hours did you sleep at night when you stayed in this hotel?'…”

Section: Nocturnal Sleep Durationmentioning

confidence: 99%

Effects of Environmental Change on Travelers’ Sleep Health: Identifying Risk and Protective Factors

Xiong

Fan

2020

Front. Psychol.

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The aim of this study is to predict the risk and protective factors for the differential effects of the environment on travelers' sleep health. Methods: A sample of 505 travelers who stayed overnight in one of 28 hotels completed a sleep quality scale (SQS), a reduced scale of the Morningness/Eveningness questionnaire (rMEQ), and a hotel customer satisfaction questionnaire (H-SCI). Results: Individuals who are of morning type (p = 0.002), have reduced sleep duration (p = 0.010), and have high sensitivity to the sleep environment (p = 0.000) are most affected by environmental change. Interestingly, business travelers are more affected by sleep disturbances than leisure travelers, travelers who are more satisfied with hotels are less likely to experience insomnia in a new sleep environment (p = 0.000), and insomniacs are more likely to recover from insomnia during a trip (p = 0.000). Conclusion: Environmental change has an inconsistent impact on the sleep health of different individuals. In a new sleep environment, the possible risk factors for sleep health include (1) being of morning type, (2) reduced sleep duration during trip, (3) sensitivity to the sleep environment, and (4) business stress, while a possible protective factor is satisfaction with the hotel. Possible factors aiding in recovery from home insomnia include (1) being of evening type and (2) higher satisfaction with the hotel.

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Objective sleep duration is associated with cognitive deficits in primary insomnia: BDNF may play a role

Cited by 55 publications

References 53 publications

<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

Sleep Disturbance Severity is Associated With Cognitive Impairment in Patients With First-episode, Treatment-naïve Major Depressive Disorders

Effects of Environmental Change on Travelers’ Sleep Health: Identifying Risk and Protective Factors

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